BLVRB and RPL31

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		BLVRB	RPL31
Description		biliverdin reductase B	ribosomal protein L31
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Extracellular Exosome	Nucleoplasm Cytoplasm Cytosol Ribosome Focal Adhesion Large Ribosomal Subunit Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Synapse Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Biliverdin Reductase [NAD(P)H] Activity Protein Binding Oxidoreductase Activity Transferase Activity Peptidyl-cysteine S-nitrosylase Activity Riboflavin Reductase (NADPH) Activity FMN Reductase (NADPH) Activity FMN Reductase (NADH) Activity	RNA Binding Structural Constituent Of Ribosome Protein Binding
	Biological Process	Insulin Receptor Signaling Pathway Megakaryocyte Differentiation Heme Catabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway	Cytoplasmic Translation Translation
Pathways		Heme degradation Cytoprotection by HMOX1	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs		Riboflavin NADH Biliverdine IX Alpha Flavin mononucleotide Nicotinamide adenine dinucleotide phosphate Lumichrome Mesobiliverdin IV alpha
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Otitis media ( 27632927) Otitis media (chronic) ( 27632927) Otitis media (recurrent) ( 27632927) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)
Interacting Genes		4 interacting genes: ANXA10 HMOX1 ORM1 RPL31	12 interacting genes: APP BLVRB BRCA1 CACNA1A CRKL DUX4 EIF4ENIF1 EWSR1 FOXP1 GPR20 IL7R PTEN
Entrez ID		645	6160
HPRD ID		02967	17994
Ensembl ID		ENSG00000090013	ENSG00000071082
Uniprot IDs		P30043 V9HWI1	P62899
PDB IDs		1HDO 1HE2 1HE3 1HE4 1HE5 5OOG 5OOH 6OPL 7ER6 7ER7 7ER8 7ER9 7ERA 7ERB 7ERC 7ERD 7ERE 8ELL 8ELM 8K4K	4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7XNX 7XNY 8A3D 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		Heme Oxidation Smooth Muscle Hyperplasia Heme Oxygenase (decyclizing) Activity Wound Healing Involved In Inflammatory Response Cellular Response To Cisplatin Smooth Muscle Adaptation Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Porphyrin-containing Compound Catabolic Process Negative Regulation Of Cytokine Production Erythrocyte Homeostasis Response To Cisplatin Heme Catabolic Process	Regulation Of Growth Postsynaptic Specialization Assembly Amyloid-beta Complex Growth Cone Lamellipodium Neuron Projection Organization Negative Regulation Of Gene Expression Regulation Of Developmental Process Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Cell Population Proliferation Amylin Binding Hemopoiesis Negative Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Signal Transduction Response To Peptide Cellular Response To Amyloid-beta Response To Cytokine Dendrite Development Regulation Of Cell Communication Regulation Of T Cell Migration Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Cell Communication Reproductive Behavior Regulation Of Signaling Positive Regulation Of Macromolecule Biosynthetic Process Identical Protein Binding Riboflavin Reductase (NADPH) Activity FMN Reductase (NADPH) Activity FMN Reductase (NADH) Activity Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Growth Postsynaptic Specialization Organization Negative Regulation Of Lymphocyte Apoptotic Process Negative Regulation Of Leukocyte Apoptotic Process Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Organ Growth Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Regulation Of Lymphocyte Apoptotic Process Response To Amyloid-beta Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Negative Regulation Of Cell Cycle Process Macrophage Activation Acetylcholine Receptor Activator Activity Regulation Of Macromolecule Biosynthetic Process Cellular Developmental Process Myeloid Cell Development Chemical Synaptic Transmission Regulation Of Nucleobase-containing Compound Metabolic Process
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