Schizophrenia - Wiki-Pi

Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide
TNFRSF17 and TRAF3	tumor necrosis factor receptor superfamily, member 17	TNF receptor-associated factor 3		Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TRAF3-dependent IRF activation pathway Toll-Like Receptors Cascades Negative regulators of RIG-I/MDA5 signaling TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade MyD88-independent cascade Innate Immune System Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
BICD1 and DISC1	bicaudal D homolog 1 (Drosophila)	disrupted in schizophrenia 1
BMPR1B and DCAF6	bone morphogenetic protein receptor, type IB	DDB1 and CUL4 associated factor 6	Signaling by BMP
BNIP3L and ROBO2	BCL2/adenovirus E1B 19kDa interacting protein 3-like	roundabout, axon guidance receptor, homolog 2 (Drosophila)		Axon guidance Regulation of Commissural axon pathfinding by Slit and Robo Signaling by Robo receptor
DST and TNIK	dystonin	TRAF2 and NCK interacting kinase	Cell junction organization Type I hemidesmosome assembly	Oxidative Stress Induced Senescence Cellular Senescence
DST and DISC1	dystonin	disrupted in schizophrenia 1	Cell junction organization Type I hemidesmosome assembly
BRCA1 and SMARCA2	breast cancer 1, early onset	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	ATM mediated phosphorylation of repair proteins Meiotic recombination Fanconi Anemia pathway ATM mediated response to DNA double-strand break Homologous Recombination Repair Meiotic synapsis Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Double-Strand Break Repair	Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines
BRCA1 and NFKB1	breast cancer 1, early onset	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	ATM mediated phosphorylation of repair proteins Meiotic recombination Fanconi Anemia pathway ATM mediated response to DNA double-strand break Homologous Recombination Repair Meiotic synapsis Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Double-Strand Break Repair	Signaling by the B Cell Receptor (BCR) NF-kB is activated and signals survival Downstream TCR signaling Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Downstream signaling events of B Cell Receptor (BCR) FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs p75NTR signals via NF-kB Transcriptional regulation of white adipocyte differentiation MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Regulated proteolysis of p75NTR Signalling by NGF TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Senescence-Associated Secretory Phenotype (SASP) Cytokine Signaling in Immune system p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Signaling by Interleukins TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Interleukin-1 processing Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Activation of NF-kappaB in B cells Fc epsilon receptor (FCERI) signaling TRAF6 mediated NF-kB activation Interleukin-1 signaling Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex		Thalidomide Pranlukast Triflusal
BRCA1 and MAP4K4	breast cancer 1, early onset	mitogen-activated protein kinase kinase kinase kinase 4	ATM mediated phosphorylation of repair proteins Meiotic recombination Fanconi Anemia pathway ATM mediated response to DNA double-strand break Homologous Recombination Repair Meiotic synapsis Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Double-Strand Break Repair	Oxidative Stress Induced Senescence Cellular Senescence
BRCA1 and NKAPL	breast cancer 1, early onset	NFKB activating protein-like	ATM mediated phosphorylation of repair proteins Meiotic recombination Fanconi Anemia pathway ATM mediated response to DNA double-strand break Homologous Recombination Repair Meiotic synapsis Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Double-Strand Break Repair
BRCA1 and ENO1	breast cancer 1, early onset	enolase 1, (alpha)	ATM mediated phosphorylation of repair proteins Meiotic recombination Fanconi Anemia pathway ATM mediated response to DNA double-strand break Homologous Recombination Repair Meiotic synapsis Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Double-Strand Break Repair	Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Glycolysis Metabolism of carbohydrates
KLF5 and NFKB1	Kruppel-like factor 5 (intestinal)	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	Transcriptional regulation of white adipocyte differentiation	Signaling by the B Cell Receptor (BCR) NF-kB is activated and signals survival Downstream TCR signaling Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Downstream signaling events of B Cell Receptor (BCR) FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs p75NTR signals via NF-kB Transcriptional regulation of white adipocyte differentiation MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Regulated proteolysis of p75NTR Signalling by NGF TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Senescence-Associated Secretory Phenotype (SASP) Cytokine Signaling in Immune system p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Signaling by Interleukins TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Interleukin-1 processing Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Activation of NF-kappaB in B cells Fc epsilon receptor (FCERI) signaling TRAF6 mediated NF-kB activation Interleukin-1 signaling Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex		Thalidomide Pranlukast Triflusal
C1QBP and PRRC2A	complement component 1, q subcomponent binding protein	proline-rich coiled-coil 2A	Intrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)
SERPING1 and BAG6	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	BCL2-associated athanogene 6	Intrinsic Pathway Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Formation of Fibrin Clot (Clotting Cascade)
SERPING1 and ENO1	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	enolase 1, (alpha)	Intrinsic Pathway Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Formation of Fibrin Clot (Clotting Cascade)	Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Glycolysis Metabolism of carbohydrates
C1QA and BAG6	complement component 1, q subcomponent, A chain	BCL2-associated athanogene 6	Classical antibody-mediated complement activation Creation of C4 and C2 activators Complement cascade Initial triggering of complement Innate Immune System
MPPED1 and DISC1	metallophosphoesterase domain containing 1	disrupted in schizophrenia 1
CACNA1C and GNB1	calcium channel, voltage-dependent, L type, alpha 1C subunit	guanine nucleotide binding protein (G protein), beta polypeptide 1	NCAM1 interactions Axon guidance Integration of energy metabolism Regulation of insulin secretion NCAM signaling for neurite out-growth Adrenaline,noradrenaline inhibits insulin secretion	Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Olfactory Signaling Pathway Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Diseases associated with visual transduction Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade G beta:gamma signalling through PI3Kgamma The phototransduction cascade G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Visual phototransduction Ca2+ pathway G-protein activation	Isradipine Ibutilide Amlodipine Nimodipine Nisoldipine Cinnarizine Nicardipine Magnesium Sulfate Verapamil Felodipine Nitrendipine Nifedipine Calcium Mibefradil Dronedarone Clevidipine Nilvadipine Drotaverine
CACNA1C and PCBD1	calcium channel, voltage-dependent, L type, alpha 1C subunit	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha	NCAM1 interactions Axon guidance Integration of energy metabolism Regulation of insulin secretion NCAM signaling for neurite out-growth Adrenaline,noradrenaline inhibits insulin secretion	Phenylalanine and tyrosine catabolism Metabolism of amino acids and derivatives	Isradipine Ibutilide Amlodipine Nimodipine Nisoldipine Cinnarizine Nicardipine Magnesium Sulfate Verapamil Felodipine Nitrendipine Nifedipine Calcium Mibefradil Dronedarone Clevidipine Nilvadipine Drotaverine
CACNA1C and CABP1	calcium channel, voltage-dependent, L type, alpha 1C subunit	calcium binding protein 1	NCAM1 interactions Axon guidance Integration of energy metabolism Regulation of insulin secretion NCAM signaling for neurite out-growth Adrenaline,noradrenaline inhibits insulin secretion		Isradipine Ibutilide Amlodipine Nimodipine Nisoldipine Cinnarizine Nicardipine Magnesium Sulfate Verapamil Felodipine Nitrendipine Nifedipine Calcium Mibefradil Dronedarone Clevidipine Nilvadipine Drotaverine

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