| RERE and ZMYND8 |
arginine-glutamic acid dipeptide (RE) repeats |
zinc finger, MYND-type containing 8 |
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| RERE and ECM1 |
arginine-glutamic acid dipeptide (RE) repeats |
extracellular matrix protein 1 |
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| RERE and TRIM22 |
arginine-glutamic acid dipeptide (RE) repeats |
tripartite motif containing 22 |
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- Interferon gamma signaling
- Interferon Signaling
- Cytokine Signaling in Immune system
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| RERE and PLSCR1 |
arginine-glutamic acid dipeptide (RE) repeats |
phospholipid scramblase 1 |
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| RERE and HIST2H3C |
arginine-glutamic acid dipeptide (RE) repeats |
histone cluster 2, H3c |
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- RNA Polymerase I Chain Elongation
- RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
- Mitotic Prophase
- PKMTs methylate histone lysines
- Regulatory RNA pathways
- RNA Polymerase I Promoter Clearance
- HDMs demethylate histones
- Cellular Senescence
- Signaling by Wnt
- HATs acetylate histones
- M Phase
- Amyloids
- NoRC negatively regulates rRNA expression
- RNF mutants show enhanced WNT signaling and proliferation
- XAV939 inhibits tankyrase, stabilizing AXIN
- DNA methylation
- Transcriptional regulation by small RNAs
- Meiotic recombination
- HDACs deacetylate histones
- Chromatin organization
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- RNA Polymerase I Transcription
- formation of the beta-catenin:TCF transactivating complex
- Epigenetic regulation of gene expression
- Senescence-Associated Secretory Phenotype (SASP)
- Negative epigenetic regulation of rRNA expression
- Factors involved in megakaryocyte development and platelet production
- PRC2 methylates histones and DNA
- Cell Cycle, Mitotic
- RMTs methylate histone arginines
- Chromatin modifying enzymes
- Oxidative Stress Induced Senescence
- TCF dependent signaling in response to WNT
- RNA Polymerase I Promoter Opening
- SIRT1 negatively regulates rRNA Expression
- Signaling by WNT in cancer
- Condensation of Prophase Chromosomes
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| RERE and PRRC2B |
arginine-glutamic acid dipeptide (RE) repeats |
proline-rich coiled-coil 2B |
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| RERE and RBFOX2 |
arginine-glutamic acid dipeptide (RE) repeats |
RNA binding protein, fox-1 homolog (C. elegans) 2 |
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| RERE and ALG13 |
arginine-glutamic acid dipeptide (RE) repeats |
ALG13, UDP-N-acetylglucosaminyltransferase subunit |
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- Defective ALG2 causes ALG2-CDG (CDG-1i)
- Diseases of glycosylation
- Defective ALG3 causes ALG3-CDG (CDG-1d)
- Post-translational protein modification
- Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
- Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
- Defective ALG1 causes ALG1-CDG (CDG-1k)
- Defective MGAT2 causes MGAT2-CDG (CDG-2a)
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Defective MOGS causes MOGS-CDG (CDG-2b)
- Defective ALG6 causes ALG6-CDG (CDG-1c)
- Defective RFT1 causes RFT1-CDG (CDG-1n)
- Asparagine N-linked glycosylation
- Defective ALG8 causes ALG8-CDG (CDG-1h)
- Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
- Defective ALG9 causes ALG9-CDG (CDG-1l)
- Defective MAN1B1 causes MRT15
- Defective MPDU1 causes MPDU1-CDG (CDG-1f)
- Defective ALG12 causes ALG12-CDG (CDG-1g)
- Defective ALG11 causes ALG11-CDG (CDG-1p)
- Diseases associated with N-glycosylation of proteins
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| ATP6V1B2 and TCF4 |
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 |
transcription factor 4 |
- Phagosomal maturation (early endosomal stage)
- Iron uptake and transport
- Latent infection of Homo sapiens with Mycobacterium tuberculosis
- Transferrin endocytosis and recycling
- Insulin receptor recycling
- Signaling by Insulin receptor
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- CDO in myogenesis
- Myogenesis
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| ATP5O and NT5C2 |
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit |
5-nucleotidase, cytosolic II |
- Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
- The citric acid (TCA) cycle and respiratory electron transport
- Formation of ATP by chemiosmotic coupling
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- Purine catabolism
- Purine metabolism
- Metabolism of nucleotides
- Abacavir transport and metabolism
- Abacavir metabolism
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- Adenosine triphosphate
- Ribavirin
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| ATRX and HDAC4 |
alpha thalassemia/mental retardation syndrome X-linked |
histone deacetylase 4 |
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- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Signaling by NOTCH
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- NOTCH1 Intracellular Domain Regulates Transcription
- Signaling by NOTCH1
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1 in Cancer
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
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| B2M and BAG6 |
beta-2-microglobulin |
BCL2-associated athanogene 6 |
- DAP12 interactions
- Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
- HIV Infection
- Host Interactions of HIV factors
- Interferon Signaling
- The role of Nef in HIV-1 replication and disease pathogenesis
- Cytokine Signaling in Immune system
- Nef mediated downregulation of MHC class I complex cell surface expression
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
- Interferon gamma signaling
- Amyloids
- DAP12 signaling
- Endosomal/Vacuolar pathway
- Class I MHC mediated antigen processing & presentation
- Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
- Antigen processing-Cross presentation
- ER-Phagosome pathway
- Innate Immune System
- Adaptive Immune System
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| BARD1 and FEZ1 |
BRCA1 associated RING domain 1 |
fasciculation and elongation protein zeta 1 (zygin I) |
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| BCL2L2 and TCF4 |
BCL2-like 2 |
transcription factor 4 |
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- CDO in myogenesis
- Myogenesis
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| BCL3 and NFKB1 |
B-cell CLL/lymphoma 3 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
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- Signaling by the B Cell Receptor (BCR)
- NF-kB is activated and signals survival
- Downstream TCR signaling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Cellular Senescence
- RIP-mediated NFkB activation via ZBP1
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- Toll Like Receptor TLR1:TLR2 Cascade
- Downstream signaling events of B Cell Receptor (BCR)
- FCERI mediated NF-kB activation
- MyD88 cascade initiated on plasma membrane
- Toll Like Receptor 5 (TLR5) Cascade
- ZBP1(DAI) mediated induction of type I IFNs
- p75NTR signals via NF-kB
- Transcriptional regulation of white adipocyte differentiation
- MyD88 dependent cascade initiated on endosome
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- MyD88:Mal cascade initiated on plasma membrane
- Toll Like Receptor 9 (TLR9) Cascade
- Innate Immune System
- Regulated proteolysis of p75NTR
- Signalling by NGF
- TRIF-mediated TLR3/TLR4 signaling
- Cytosolic sensors of pathogen-associated DNA
- Senescence-Associated Secretory Phenotype (SASP)
- Cytokine Signaling in Immune system
- p75 NTR receptor-mediated signalling
- MyD88-independent cascade
- Toll Like Receptor 2 (TLR2) Cascade
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Signaling by Interleukins
- TCR signaling
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Interleukin-1 processing
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Activation of NF-kappaB in B cells
- Fc epsilon receptor (FCERI) signaling
- TRAF6 mediated NF-kB activation
- Interleukin-1 signaling
- Adaptive Immune System
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
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- Thalidomide
- Pranlukast
- Triflusal
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| BCL6 and HDAC4 |
B-cell CLL/lymphoma 6 |
histone deacetylase 4 |
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- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Signaling by NOTCH
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- NOTCH1 Intracellular Domain Regulates Transcription
- Signaling by NOTCH1
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1 in Cancer
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
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| BCL6 and FBXO11 |
B-cell CLL/lymphoma 6 |
F-box protein 11 |
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| BCL9 and PYGO2 |
B-cell CLL/lymphoma 9 |
pygopus family PHD finger 2 |
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TCF dependent signaling in response to WNT
- RNF mutants show enhanced WNT signaling and proliferation
- formation of the beta-catenin:TCF transactivating complex
- XAV939 inhibits tankyrase, stabilizing AXIN
- Signaling by Wnt
- Signaling by WNT in cancer
- deactivation of the beta-catenin transactivating complex
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- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TCF dependent signaling in response to WNT
- RNF mutants show enhanced WNT signaling and proliferation
- formation of the beta-catenin:TCF transactivating complex
- XAV939 inhibits tankyrase, stabilizing AXIN
- Signaling by Wnt
- Signaling by WNT in cancer
- deactivation of the beta-catenin transactivating complex
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| BCL9 and CTNNB1 |
B-cell CLL/lymphoma 9 |
catenin (cadherin-associated protein), beta 1, 88kDa |
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TCF dependent signaling in response to WNT
- RNF mutants show enhanced WNT signaling and proliferation
- formation of the beta-catenin:TCF transactivating complex
- XAV939 inhibits tankyrase, stabilizing AXIN
- Signaling by Wnt
- Signaling by WNT in cancer
- deactivation of the beta-catenin transactivating complex
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- APC truncation mutants have impaired AXIN binding
- misspliced GSK3beta mutants stabilize beta-catenin
- T41 mutants of beta-catenin aren't phosphorylated
- TCF7L2 mutants don't bind CTBP
- truncated APC mutants destabilize the destruction complex
- Signaling by Wnt
- binding of TCF/LEF:CTNNB1 to target gene promoters
- deactivation of the beta-catenin transactivating complex
- APC truncation mutants are not K63 polyubiquitinated
- disassembly of the destruction complex and recruitment of AXIN to the membrane
- S37 mutants of beta-catenin aren't phosphorylated
- Degradation of beta-catenin by the destruction complex
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- RNF mutants show enhanced WNT signaling and proliferation
- S33 mutants of beta-catenin aren't phosphorylated
- XAV939 inhibits tankyrase, stabilizing AXIN
- Innate Immune System
- truncations of AMER1 destabilize the destruction complex
- CDO in myogenesis
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- Cytosolic sensors of pathogen-associated DNA
- formation of the beta-catenin:TCF transactivating complex
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- AXIN missense mutants destabilize the destruction complex
- S45 mutants of beta-catenin aren't phosphorylated
- repression of WNT target genes
- beta-catenin independent WNT signaling
- deletions in the AMER1 gene destabilize the destruction complex
- Ca2+ pathway
- Myogenesis
- AMER1 mutants destabilize the destruction complex
- TCF dependent signaling in response to WNT
- LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- Signaling by WNT in cancer
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| BCL9 and PYGO1 |
B-cell CLL/lymphoma 9 |
pygopus family PHD finger 1 |
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TCF dependent signaling in response to WNT
- RNF mutants show enhanced WNT signaling and proliferation
- formation of the beta-catenin:TCF transactivating complex
- XAV939 inhibits tankyrase, stabilizing AXIN
- Signaling by Wnt
- Signaling by WNT in cancer
- deactivation of the beta-catenin transactivating complex
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- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TCF dependent signaling in response to WNT
- RNF mutants show enhanced WNT signaling and proliferation
- formation of the beta-catenin:TCF transactivating complex
- XAV939 inhibits tankyrase, stabilizing AXIN
- Signaling by Wnt
- Signaling by WNT in cancer
- deactivation of the beta-catenin transactivating complex
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