MED1 and GATA6

Number of citations of the paper that reports this interaction (PMID 11724781)
31

Data Source:
HPRD (in vitro)

		MED1	GATA6
Gene Name		mediator complex subunit 1	GATA binding protein 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Membrane Mediator Complex Protein-DNA Complex	Nucleus Nucleoplasm Transcription Factor Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Binding RNA Polymerase II Transcription Cofactor Activity Chromatin Binding Transcription Cofactor Activity Transcription Coactivator Activity Receptor Activity Protein Binding Transcription Factor Binding Ligand-dependent Nuclear Receptor Binding Estrogen Receptor Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Thyroid Hormone Receptor Coactivator Activity Chromatin DNA Binding Nuclear Hormone Receptor Binding Mediator Complex Binding Vitamin D Receptor Binding Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Thyroid Hormone Receptor Binding LBD Domain Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Repressing Transcription Factor Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Protein Kinase Binding Transcription Regulatory Region DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Angiogenesis Liver Development Embryonic Placenta Development Lens Development In Camera-type Eye Thyroid Hormone Mediated Signaling Pathway Ventricular Trabecula Myocardium Morphogenesis Retinal Pigment Epithelium Development Regulation Of Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase II Promoter Thyroid Hormone Generation Androgen Biosynthetic Process Brain Development Lactation Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Monocyte Differentiation Intracellular Steroid Hormone Receptor Signaling Pathway Androgen Receptor Signaling Pathway Organ Regeneration Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Protein Import Into Nucleus, Translocation Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Embryonic Heart Tube Development Embryonic Hindlimb Morphogenesis Embryonic Hemopoiesis Peroxisome Proliferator Activated Receptor Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Megakaryocyte Development MRNA Transcription From RNA Polymerase II Promoter Negative Regulation Of Apoptotic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Fat Cell Differentiation Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Erythrocyte Development Enucleate Erythrocyte Development Regulation Of Cell Cycle Positive Regulation Of Interferon-gamma-mediated Signaling Pathway Mammary Gland Branching Involved In Thelarche Mammary Gland Branching Involved In Pregnancy Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of G0 To G1 Transition ERK1 And ERK2 Cascade Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Steroid Hormone Stimulus Cellular Response To Thyroid Hormone Stimulus Positive Regulation Of Receptor Activity Positive Regulation Of Hepatocyte Proliferation Regulation Of RNA Biosynthetic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Liver Development Outflow Tract Septum Morphogenesis Type B Pancreatic Cell Differentiation Pancreatic A Cell Differentiation Transcription From RNA Polymerase II Promoter Phospholipid Metabolic Process Endodermal Cell Fate Determination Blood Coagulation Male Gonad Development Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Transforming Growth Factor Beta2 Production Response To Drug Negative Regulation Of Apoptotic Process Response To Estrogen Positive Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Organ Formation Smooth Muscle Cell Differentiation Positive Regulation Of Cardioblast Differentiation Cardiac Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Lung Saccule Development Clara Cell Differentiation Type II Pneumocyte Differentiation Intestinal Epithelial Cell Differentiation Cardiac Vascular Smooth Muscle Cell Differentiation Response To Growth Factor Positive Regulation Of Cell Cycle Arrest Cellular Response To Gonadotropin Stimulus Cellular Response To Hypoxia Cellular Response To BMP Stimulus
Pathways		PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Nuclear Receptor transcription pathway REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis Regulation of cholesterol biosynthesis by SREBP (SREBF) Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation YAP1- and WWTR1 (TAZ)-stimulated gene expression Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression Orphan transporters	Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Tuberculosis ( 20694014)
Protein-Protein Interactions		42 interactors: AR BRCA1 CTDP1 ESR1 ESR2 EZH2 GABPA GATA1 GATA3 GATA4 GATA6 GJB5 HNF4A KIF1A MDM2 MED12 MED14 MED25 MED29 MED8 MED9 MYC NCOA6 NR1H2 NR1I3 NR3C1 NR4A1 PIN1 PPARA PPARG PPARGC1A RARA RORA RXRA RXRB SREBF1 THRA THRB TP53 VDR YWHAH YWHAQ	7 interactors: CRIP2 EP300 HHEX KLF2 KPNA3 MED1 NKX2-1
Entrez ID		5469	2627
HPRD ID		05055	09043
Ensembl ID		ENSG00000125686	ENSG00000141448
Uniprot IDs		Q15648	Q53EU2 Q92908
PDB IDs		1RJK 1RK3 1RKG 1RKH 2O4J 2O4R 2ZFX 3A2H 3AUN 3VJS 3VJT 3VRT 3VRU 3VRV 3VRW 3W5P 3W5Q 3W5R 3W5T
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated Hormone-mediated Signaling Pathway Response To Steroid Hormone Cellular Response To Steroid Hormone Stimulus RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Hormone Stimulus Response To Hormone Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Response To Lipid Response To Lipid Regulation Of Transcription, DNA-templated RNA Metabolic Process Response To Organic Cyclic Compound Regulation Of Nucleic Acid-templated Transcription Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Cellular Response To Organic Cyclic Compound Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Response To Organic Substance Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Response To Organic Substance Negative Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process	Lung Development Respiratory Tube Development Tube Development Respiratory System Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Epithelium Development Epithelial Cell Differentiation Response To Organic Substance Positive Regulation Of Transcription, DNA-templated Hemopoiesis Positive Regulation Of Macromolecule Biosynthetic Process Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Gene Expression Thyroid Gland Development Immune System Development Organ Development Positive Regulation Of Cellular Biosynthetic Process Morphogenesis Of A Branching Epithelium Negative Regulation Of Transcription From RNA Polymerase II Promoter Myeloid Cell Differentiation Tissue Development Chordate Embryonic Development Morphogenesis Of A Branching Structure Embryo Development Ending In Birth Or Egg Hatching Regulation Of Transcription From RNA Polymerase II Promoter Erythrocyte Development Response To Hormone Epithelial Tube Branching Involved In Lung Morphogenesis Organ Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Immune System Process Anatomical Structure Formation Involved In Morphogenesis Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Lung Epithelial Cell Differentiation Epithelial Tube Morphogenesis Negative Regulation Of Transcription, DNA-templated Lung Cell Differentiation Transcription, DNA-templated Lung Morphogenesis Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryo Development Lung Epithelium Development System Development RNA Biosynthetic Process Anatomical Structure Morphogenesis Tube Morphogenesis Embryonic Heart Tube Development Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		adam9 aurka birc5 c11orf30 ccne1 cdc6 cdh1 cpd devoid emsy esr1 fgfr1 holland ikbkb mapt mathematical meaning microdissection mlpa mrc mtdh multiplex numerical p078 prdm14 qiagen salsa top2a traf4	adaptations backgrounddietary blastocysts compensatory conclusionsfirst ebs emb embryoid endoderm gata4 gestation h3k4me2 h3k9me3 lpd npd offspring pe preimplantation primitive programming propagate resultsemb retain sac stabilised trophectoderm unaltered uterus yolk
Tagcloud (Difference) ?		adam9 aurka birc5 c11orf30 ccne1 cdc6 cdh1 cpd devoid emsy esr1 fgfr1 holland ikbkb mapt mathematical meaning microdissection mlpa mrc mtdh multiplex numerical p078 prdm14 qiagen salsa top2a traf4	adaptations backgrounddietary blastocysts compensatory conclusionsfirst ebs emb embryoid endoderm gata4 gestation h3k4me2 h3k9me3 lpd npd offspring pe preimplantation primitive programming propagate resultsemb retain sac stabilised trophectoderm unaltered uterus yolk
Tagcloud (Intersection) ?