OXSR1 and SLC12A1

Number of citations of the paper that reports this interaction (PMID 12386165)
76

Data Source:
HPRD (two hybrid)

		OXSR1	SLC12A1
Gene Name		oxidative stress responsive 1	solute carrier family 12 (sodium/potassium/chloride transporter), member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Extracellular Vesicular Exosome	Plasma Membrane Membrane Integral Component Of Membrane Apical Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Sodium:potassium:chloride Symporter Activity
	Biological Process	Protein Phosphorylation Response To Oxidative Stress Peptidyl-threonine Phosphorylation Signal Transduction By Phosphorylation Intracellular Signal Transduction Cellular Hypotonic Response Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Rubidium Ion Transmembrane Transporter Activity	Kidney Development Transport Ion Transport Potassium Ion Transport Sodium Ion Transport Chloride Transport Excretion Ion Transmembrane Transport Chemical Homeostasis Transmembrane Transport Chloride Transmembrane Transport
Pathways			Transport of inorganic cations/anions and amino acids/oligopeptides Cation-coupled Chloride cotransporters SLC-mediated transmembrane transport
Drugs			Torasemide Methyclothiazide Chlorthalidone Chlormerodrin Furosemide Potassium Chloride Hydroflumethiazide Bumetanide Ethacrynic acid Trichlormethiazide Quinethazone Piretanide
Diseases
GWAS
Protein-Protein Interactions		10 interactors: APP BMPR1B PAK1 RELL1 RELL2 SLC12A1 SLC12A2 SLC12A6 SMURF1 TGFBR1	2 interactors: OXSR1 STK39
Entrez ID		9943	6557
HPRD ID		06809	02908
Ensembl ID		ENSG00000172939	ENSG00000074803
Uniprot IDs		O95747	B4DPF4 E9PDW4 Q13621 Q8IUN5
PDB IDs		2V3S 2VWI 3DAK
Enriched GO Terms of Interacting Partners?		Response To Osmotic Stress Chloride Transmembrane Transport Chloride Transport Anatomical Structure Development Hyperosmotic Response Potassium Ion Transport Developmental Process Anatomical Structure Morphogenesis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Inorganic Anion Transport Signal Transduction By Phosphorylation Developmental Growth System Development Peptidyl-threonine Phosphorylation Neuromuscular Junction Development Tissue Development Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Multicellular Organismal Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Axon Guidance BMP Signaling Pathway Anion Transmembrane Transport Positive Regulation Of Cell Volume Rubidium Ion Transport Cellular Hypotonic Salinity Response Cell Morphogenesis Response To Abiotic Stimulus Regulation Of Cartilage Development Neuron Differentiation Response To Stress Epithelial Cell Migration Epithelium Migration Growth Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Synaptic Growth At Neuromuscular Junction Negative Regulation Of Chondrocyte Proliferation Ovarian Cumulus Expansion Locomotion Axonogenesis Protein Phosphorylation Axon Development Transepithelial Ammonium Transport Collateral Sprouting In Absence Of Injury Cell Morphogenesis Involved In Neuron Differentiation Dendrite Development Wound Healing	Negative Regulation Of Rubidium Ion Transport Negative Regulation Of Rubidium Ion Transmembrane Transporter Activity Regulation Of Rubidium Ion Transport Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transport Cellular Hypotonic Response Hypotonic Response Negative Regulation Of Potassium Ion Transport Regulation Of Potassium Ion Transmembrane Transporter Activity Cellular Response To Osmotic Stress Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Transporter Activity Peptidyl-threonine Phosphorylation Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Regulation Of Potassium Ion Transport Response To Osmotic Stress Negative Regulation Of Ion Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Signal Transduction By Phosphorylation Negative Regulation Of Transport Regulation Of Ion Transmembrane Transport Regulation Of Ion Transport Peptidyl-amino Acid Modification Response To Abiotic Stimulus Positive Regulation Of Potassium Ion Transport Protein Phosphorylation Cellular Response To Stress Phosphorylation Intracellular Signal Transduction Peptidyl-serine Phosphorylation Phosphate-containing Compound Metabolic Process Positive Regulation Of Ion Transport Cellular Protein Modification Process Response To Stress Regulation Of Inflammatory Response Cellular Protein Metabolic Process Response To Oxidative Stress
Tagcloud ?			adaptations adjustments alpha1beta1 arystarkhova ascending atpase compensatory convoluted cotransporter dct fxyd fxyd2 generates hypoplasia na ncc nephron nkcc2 nonetheless permissive reabsorption s71 segment t53 thiazide thick tubule twofold
Tagcloud (Difference) ?			adaptations adjustments alpha1beta1 arystarkhova ascending atpase compensatory convoluted cotransporter dct fxyd fxyd2 generates hypoplasia na ncc nephron nkcc2 nonetheless permissive reabsorption s71 segment t53 thiazide thick tubule twofold
Tagcloud (Intersection) ?