OXSR1 and WNK2

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology, unspecified method)

		OXSR1	WNK2
Description		oxidative stress responsive kinase 1	WNK lysine deficient protein kinase 2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Potassium Channel Inhibitor Activity Protein Kinase Binding Identical Protein Binding Transmembrane Transporter Binding Metal Ion Binding Ion Channel Regulator Activity Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Cell Volume Homeostasis Response To Oxidative Stress Signal Transduction Osmosensory Signaling Pathway Response To Xenobiotic Stimulus Positive Regulation Of T Cell Chemotaxis Intracellular Signal Transduction Chemokine (C-C Motif) Ligand 21 Signaling Pathway Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Protein Autophosphorylation Renal Sodium Ion Absorption Cellular Hyperosmotic Response Cellular Hypotonic Response Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Cellular Response To Chemokine	Protein Phosphorylation DNA Damage Response Negative Regulation Of Cell Population Proliferation Intracellular Signal Transduction Homeostatic Process Protein Autophosphorylation Monoatomic Ion Homeostasis Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways			Stimuli-sensing channels
Drugs		Fostamatinib
Diseases
GWAS		Gut microbiota (bacterial taxa) ( 27723756) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494)	Ability to confide in someone ( 29970889) Bipolar disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Fasting glucose ( 33381925) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Perceived sweetness of sucrose ( 31005972)
Interacting Genes		14 interacting genes: AKT1 APP BMPR1B OGT PAK1 RELL1 SLC12A1 SLC12A2 SLC12A6 SMURF1 TGFBR1 WNK1 WNK2 WNK4	6 interacting genes: ATXN1 ESS2 MTDH OXSR1 WNK1 YWHAZ
Entrez ID		9943	65268
HPRD ID		06809	06951
Ensembl ID		ENSG00000172939	ENSG00000165238
Uniprot IDs		O95747	E9PCD1 Q9Y3S1
PDB IDs		2V3S 2VWI 3DAK 7OKW	6ELM 6FBK
Enriched GO Terms of Interacting Partners?		Monoatomic Anion Homeostasis Chloride Ion Homeostasis Chemical Homeostasis Protein Serine/threonine Kinase Activity Cell Volume Homeostasis Potassium Ion Homeostasis Chloride:monoatomic Cation Symporter Activity Intracellular Chloride Ion Homeostasis Monoatomic Ion Homeostasis Protein Kinase Activity Potassium Ion Transmembrane Transport Potassium Ion Transport Membrane Regulation Of Sodium Ion Transport Transferase Activity Homeostatic Process Kinase Activity Regulation Of Cell Size Cellular Homeostasis Response To Stress Inorganic Ion Homeostasis Sodium:potassium:chloride Symporter Activity Chloride Transport Potassium Ion Transmembrane Transporter Activity Protein-containing Complex Monoatomic Cation Homeostasis Positive Regulation Of Signal Transduction Negative Regulation Of Multicellular Organismal Process Intracellular Chemical Homeostasis Protein Metabolic Process Sodium Ion Transmembrane Transport Regulation Of Developmental Growth Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Transforming Growth Factor Beta Receptor Activity, Type I Inorganic Anion Transport Monoatomic Anion Transport Negative Regulation Of Pancreatic Juice Secretion Regulation Of Protein Localization Potassium Ion Import Across Plasma Membrane Positive Regulation Of Developmental Process Metal Ion Transport Regulation Of Developmental Process Regulation Of Protein Localization To Cell Periphery Protein Phosphorylation Inorganic Cation Transmembrane Transport Regulation Of Metal Ion Transport Regulation Of Spontaneous Synaptic Transmission SMAD Binding	Chemokine (C-C Motif) Ligand 21 Signaling Pathway Cellular Response To Chemokine Positive Regulation Of T Cell Chemotaxis Regulation Of T Cell Chemotaxis Positive Regulation Of Lymphocyte Chemotaxis Cellular Hyperosmotic Response Regulation Of Lymphocyte Chemotaxis Hyperosmotic Response Positive Regulation Of T Cell Migration Cell Volume Homeostasis Positive Regulation Of Lymphocyte Migration Cellular Response To Osmotic Stress Regulation Of T Cell Migration Protein Phosphorylation Phosphorylation Regulation Of Lymphocyte Migration Response To Osmotic Stress Chemokine-mediated Signaling Pathway Regulation Of Cell Size Protein Kinase Binding Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Chemotaxis Negative Regulation Of Monoatomic Ion Transport Synaptic Target Recognition Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Transmembrane Transporter Binding Regulation Of Mononuclear Cell Migration Positive Regulation Of Chemotaxis Positive Regulation Of Leukocyte Migration Potassium Ion Transmembrane Transport POZ Domain Binding Potassium Ion Transport Lymphocyte Migration Into Lymph Node Positive Regulation Of Termination Of DNA-templated Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription Sodium Ion Transport Positive Regulation Of Vasculature Development Positive Regulation Of Angiogenesis Golgi Reassembly Negative Regulation Of Pancreatic Juice Secretion Phosphoserine Residue Binding Intercellular Canaliculus Cell Surface Receptor Signaling Pathway Negative Regulation Of Protein Localization Ion Channel Regulator Activity Regulation Of Chemotaxis Intracellular Membraneless Organelle Regulation Of Leukocyte Migration Poly(G) Binding Establishment Of Golgi Localization
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