MAFB and MAF

Number of citations of the paper that reports this interaction (PubMedID 23661758)
48

Data Source:
BioGRID (fluorescent resonance energy transfer, fluorescent resonance energy transfer)

		MAFB	MAF
Description		MAF bZIP transcription factor B	MAF bZIP transcription factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Protein-containing Complex Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Segment Specification Sensory Organ Development Response To Nutrient Respiratory Gaseous Exchange By Respiratory System Gene Expression Protein Processing Rhombomere 5 Development Rhombomere 6 Development Abducens Nerve Formation Keratinocyte Differentiation T Cell Differentiation In Thymus Brain Segmentation Inner Ear Morphogenesis Fat Cell Differentiation Regulation Of Myeloid Cell Differentiation Negative Regulation Of Erythrocyte Differentiation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Thymus Development Integrated Stress Response Signaling Cornified Envelope Assembly	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Lens Development In Camera-type Eye Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Response To Nutrient Gene Expression Positive Regulation Of Gene Expression Megakaryocyte Differentiation Regulation Of Chondrocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cell Development Inner Ear Development Lens Fiber Cell Differentiation Integrated Stress Response Signaling
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	RUNX2 regulates osteoblast differentiation
Drugs
Diseases			Multiple myeloma
GWAS		Adult body size ( 32376654) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Birth weight ( 31043758 27680694) Bone mineral density (hip) ( 30172743) Cholesterol, total ( 20686565 24097068 25961943) Cognitive decline rate in late mild cognitive impairment ( 26252872) Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN) ( 21221126) Dupuytren's disease ( 21732829 28886342) Height ( 25282103) Iron status biomarkers (ferritin levels) ( 33536631) LDL cholesterol ( 25961943 24097068 20686565 19060906) LDL cholesterol levels ( 28334899 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 33339817) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280) Obesity-related traits ( 23251661) Paneth cell defects in Crohn's disease ( 28352666) Plasma parathyroid hormone levels ( 30134803) QT interval (ambient particulate matter interaction) ( 28749367) Red blood cell count ( 32888494) Response to TNF antagonist treatment ( 18615156) Serum alkaline phosphatase levels ( 33547301) Serum total protein levels ( 29403010) Spleen volume ( 34128465) Total body bone mineral density ( 29304378) Total cholesterol levels ( 33339817) Triglyceride levels ( 32203549) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Alanine aminotransferase levels ( 34315874 33547301) Alzheimer's disease (late onset) ( 30820047) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 34315874 33547301) Colorectal cancer ( 31826910 30529582) Depressive symptoms (SSRI exposure interaction) ( 25649181) Estimated glomerular filtration rate ( 31015462) Height ( 20668459) High density lipoprotein cholesterol levels ( 33339817) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lysophosphatidylcholine levels ( 31551469) Macular thickness ( 30535121) Metabolite levels ( 23823483) Multiple sclerosis ( 24076602 21833088 31604244) Obesity ( 19151714) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Refractive error ( 32231278) Renal function-related traits (urate) ( 22797727) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Serum alkaline phosphatase levels ( 29403010 33547301 33339817) Serum thyroid-stimulating hormone levels ( 24852370) Serum uric acid levels ( 30993211) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Thyroid function ( 22494929) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997 25743335) Thyroid volume ( 21565293) Triglyceride levels ( 32203549) Urate levels ( 31985003 23263486) Vitamin C levels ( 33203707)
Interacting Genes		11 interacting genes: ATF4 BACH1 FOS FOSL1 HOXD12 JUN KRTAP4-2 MAF ZDHHC2 ZFP64 ZWINT	16 interacting genes: ATF4 CREBBP EP300 ETS1 FOS FOSL1 HOXD12 JUN MAFA MAFB MAFG MYB SMARCA5 SOX9 UBE2O USF2
Entrez ID		9935	4094
HPRD ID		07129	01518
Ensembl ID		ENSG00000204103	ENSG00000178573
Uniprot IDs		Q9Y5Q3	H3BP11 O75444
PDB IDs
Enriched GO Terms of Interacting Partners?		Integrated Stress Response Signaling RNA Polymerase II Transcription Regulator Complex Sequence-specific Double-stranded DNA Binding Chromatin DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of MiRNA Transcription Transcription Factor AP-1 Complex Positive Regulation Of MiRNA Metabolic Process Promoter-specific Chromatin Binding DNA Binding Transcription Regulator Complex Regulation Of MiRNA Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding General Transcription Initiation Factor Binding Regulation Of MiRNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Embryonic Hemopoiesis Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process SMAD Protein Signal Transduction Response To Muscle Stretch R-SMAD Binding Intracellular Signaling Cassette Cellular Response To Metal Ion Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Stress Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Identical Protein Binding Myeloid Cell Differentiation Transcription Cis-regulatory Region Binding Medium-term Memory Cellular Response To Prolactin Positive Regulation Of Hepatocyte Apoptotic Process Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process	Sequence-specific Double-stranded DNA Binding Chromatin Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex Transcription Regulator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Regulation Of MiRNA Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of MiRNA Metabolic Process Integrated Stress Response Signaling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of MiRNA Transcription Regulation Of RNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Intracellular Signaling Cassette Histone H3K27 Acetyltransferase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleus Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Sequence-specific DNA Binding Cellular Response To Nutrient Levels Transcription Cis-regulatory Region Binding Chromatin Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Response To Nutrient Levels
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