ZC3H11A and RAPGEF4

Number of citations of the paper that reports this interaction (PMID 24722188)
1

Data Source:
BioGRID (two hybrid)

		ZC3H11A	RAPGEF4
Gene Name		zinc finger CCCH-type containing 11A	Rap guanine nucleotide exchange factor (GEF) 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Transcription Export Complex	Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Membrane
	Molecular Function	Protein Binding Poly(A) RNA Binding Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity Ras Guanyl-nucleotide Exchange Factor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Ras GTPase Binding CAMP Binding
	Biological Process	Poly(A)+ MRNA Export From Nucleus	Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Blood Coagulation Calcium Ion-dependent Exocytosis Regulation Of Exocytosis CAMP-mediated Signaling Insulin Secretion Platelet Activation Positive Regulation Of Ras GTPase Activity Small Molecule Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Insulin Secretion
Pathways			Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Integration of energy metabolism Regulation of insulin secretion Integrin alphaIIb beta3 signaling Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: MLH1 RAPGEF4	11 interactors: ATXN1 BZRAP1 C16orf45 MAP1A RAP1A RAP2A RIMS2 RRAS2 SWAP70 TRAF2 ZC3H11A
Entrez ID		9877	11069
HPRD ID		11100	06929
Ensembl ID		ENSG00000058673	ENSG00000091428
Uniprot IDs		O75152	B7Z283 Q8WZA2
PDB IDs
Enriched GO Terms of Interacting Partners?		Meiotic Spindle Midzone Assembly Meiotic Metaphase I Plate Congression Negative Regulation Of Mitotic Recombination Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation Spindle Midzone Assembly Cell Activation Resolution Of Meiotic Recombination Intermediates Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation Double-strand Break Repair Via Nonhomologous End Joining Chromosome Separation Negative Regulation Of DNA Recombination CAMP-mediated Signaling Nuclear-transcribed MRNA Poly(A) Tail Shortening Isotype Switching Cyclic-nucleotide-mediated Signaling Metaphase Plate Congression Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Insulin Secretion Establishment Of Chromosome Localization Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Reciprocal Meiotic Recombination Calcium Ion-dependent Exocytosis B Cell Activation Involved In Immune Response Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Synapsis Mismatch Repair Homologous Chromosome Segregation Male Meiosis Immunoglobulin Production Peptide Hormone Secretion Regulation Of DNA Recombination Peptide Secretion Intracellular Signal Transduction Oogenesis MRNA 3'-end Processing Meiotic Chromosome Segregation Spindle Assembly Hormone Secretion Establishment Of Localization In Cell Hormone Transport Peptide Transport Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of DNA Metabolic Process RNA 3'-end Processing Meiosis I Female Gamete Generation Protein Secretion	Rap Protein Signal Transduction Ras Protein Signal Transduction Negative Regulation Of Cell Motility Involved In Cerebral Cortex Radial Glia Guided Migration Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Intracellular Signal Transduction Neurotransmitter Secretion Membrane Depolarization Nuclear Export Regulation Of Neurotransmitter Levels Synaptic Transmission Regulation Of Phosphorylation Regulation Of Cell Migration Regulation Of Exocytosis Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of MAPK Cascade Small GTPase Mediated Signal Transduction Regulation Of JNK Cascade Regulation Of Cell Motility Neurotransmitter Transport Regulation Of Secretion Cellular Localization Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Stress-activated MAPK Cascade Regulation Of Locomotion Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Component Movement Regulation Of Neurogenesis Negative Regulation Of Cell Migration Positive Regulation Of Protein Phosphorylation Calcium Ion-dependent Exocytosis Of Neurotransmitter Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Motility Positive Regulation Of Protein Homodimerization Activity Negative Regulation Of Cellular Component Movement
Tagcloud ?		actb arfgap2 arl1 bestkeeper bmi1 casc3 cynomolgus ddx3x gapdh genorm lists monkey morf4 mrfap1 normalization normfinder ormdl1 prerequisite reference ribosylation rps19 rsl24d1 sar1a traditionally transcriptome usp22 vitally ywhaz zranb2	adenylyl analog calr calreticulin camp chlorophenylthio cox2 cpt cyclase cyclooxygenase em1 endometrial epac epac2 establishment forskolin galactosidase glands glandular implantation lif pge2 phe pka prostaglandin ptgs2 receptivity silenced uterine
Tagcloud (Difference) ?		actb arfgap2 arl1 bestkeeper bmi1 casc3 cynomolgus ddx3x gapdh genorm lists monkey morf4 mrfap1 normalization normfinder ormdl1 prerequisite reference ribosylation rps19 rsl24d1 sar1a traditionally transcriptome usp22 vitally ywhaz zranb2	adenylyl analog calr calreticulin camp chlorophenylthio cox2 cpt cyclase cyclooxygenase em1 endometrial epac epac2 establishment forskolin galactosidase glands glandular implantation lif pge2 phe pka prostaglandin ptgs2 receptivity silenced uterine
Tagcloud (Intersection) ?