ZC3H11A and RAPGEF4

Number of citations of the paper that reports this interaction (PubMedID 24722188)
69

Data Source:
BioGRID (two hybrid)

		ZC3H11A	RAPGEF4
Description		zinc finger CCCH-type containing 11A	Rap guanine nucleotide exchange factor 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Transcription Export Complex Nucleus Nucleoplasm Nuclear Speck	Cytoplasm Cytosol Plasma Membrane Membrane Hippocampal Mossy Fiber To CA3 Synapse
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Nucleotide Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding CAMP Binding Protein-macromolecule Adaptor Activity Small GTPase Binding
	Biological Process	Poly(A)+ MRNA Export From Nucleus MRNA Transport	Adaptive Immune Response Exocytosis G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Calcium-ion Regulated Exocytosis Regulation Of Exocytosis Insulin Secretion Positive Regulation Of Insulin Secretion Intracellular Signal Transduction Hormone Secretion Regulation Of Insulin Secretion Regulation Of Synaptic Vesicle Cycle
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination	Integrin signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion
Drugs
Diseases
GWAS		Breast cancer ( 25038754) Male-pattern baldness ( 28196072)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Fasting blood glucose ( 33842983) Fasting plasma glucose ( 25187374) GLP-1 levels in response to oral glucose tolerance test (fasting) ( 29093273) HDL cholesterol levels ( 32203549) Hippocampal volume ( 25625606) Lateral ventricle temporal horn volume ( 31530798)
Interacting Genes		11 interacting genes: CEBPA MIR141 MIR214 MIR9-1 MIR9-2 MLH1 MTNR1A RAPGEF4 RNF10 SMARCB1 SUMO2	14 interacting genes: ATXN1 BMERB1 DEF6 DSCAM LRRK2 MAP1A RAP1A RAP2A RIMS2 RRAS2 SWAP70 TRAF2 TSPOAP1 ZC3H11A
Entrez ID		9877	11069
HPRD ID		11100	06929
Ensembl ID		ENSG00000058673	ENSG00000091428
Uniprot IDs		O75152	B7Z278 E9PB94 Q8WZA2 X5D7N4
PDB IDs
Enriched GO Terms of Interacting Partners?		RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Cell Population Proliferation Positive Regulation Of Nucleobase-containing Compound Metabolic Process MRNA 3'-UTR Binding Regulation Of Osteoblast Differentiation Negative Regulation Of Translation Regulation Of Cell Population Proliferation Regulation Of Gene Expression MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Catabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Hippocampal Mossy Fiber To CA3 Synapse Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Cell Differentiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Developmental Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Vitamin B2 C/EBP Complex Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Chiasma Negative Regulation Of Transformation Of Host Cell By Virus Negative Regulation Of Biosynthetic Process CHOP-C/EBP Complex Positive Regulation Of Cell Activation Regulation Of Metabolic Process Regulation Of Cell Differentiation Regulation Of Protein Metabolic Process Regulation Of Developmental Process Male Meiosis Chromosome Segregation MutLalpha Complex Positive Regulation Of Glucose Mediated Signaling Pathway Germ Cell Nucleus Regulation Of Transformation Of Host Cell By Virus	Regulation Of Neurotransmitter Secretion Regulation Of Synaptic Vesicle Exocytosis Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission GDP Binding Rap Protein Signal Transduction Regulation Of Cell Communication Regulation Of Protein Depolymerization Regulation Of Signaling Small GTPase-mediated Signal Transduction Cellular Localization GTPase Activity Regulation Of Locomotion Regulation Of Protein-containing Complex Disassembly Regulation Of Regulated Secretory Pathway Regulation Of Glial Cell Migration GTP Binding Cell Projection Regulation Of Neuron Projection Development Synaptic Vesicle Exocytosis Regulation Of Biological Quality Regulation Of Microtubule Depolymerization Regulation Of Exocytosis Intracellular Signaling Cassette Locomotory Behavior Post-embryonic Retina Morphogenesis In Camera-type Eye Positive Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Locomotion Cell Projection Morphogenesis Netrin Receptor Binding Positive Regulation Of Phosphorylation Social Behavior Neuron Projection Morphogenesis Synapse Synapse Organization Tubulin Binding Retrograde Axonal Protein Transport Primary Dendrite Establishment Of Localization In Cell Neuron Cellular Homeostasis Regulation Of Signal Transduction Small GTPase Binding Response To Antineoplastic Agent Guanyl-nucleotide Exchange Factor Activity Regulation Of MAPK Cascade Regulation Of Secretion Regulation Of Secretion By Cell G Protein Activity Nuclear Transport
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