BHLHB9 and PPP2R5E

Number of citations of the paper that reports this interaction (PMID 15034937)
4

Data Source:
HPRD (two hybrid)

		BHLHB9	PPP2R5E
Gene Name		basic helix-loop-helix domain containing, class B, 9	protein phosphatase 2, regulatory subunit B, epsilon isoform
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Extracellular Vesicular Exosome	Protein Phosphatase Type 2A Complex Cytoplasm
	Molecular Function	Protein Homodimerization Activity	Protein Binding Protein Phosphatase Type 2A Regulator Activity
	Biological Process	Learning Or Memory Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neurogenesis Positive Regulation Of Synapse Assembly Positive Regulation Of Dendritic Spine Morphogenesis	Signal Transduction Regulation Of Catalytic Activity
Pathways			Mitotic Prometaphase Costimulation by the CD28 family Separation of Sister Chromatids misspliced GSK3beta mutants stabilize beta-catenin APC truncation mutants have impaired AXIN binding T41 mutants of beta-catenin aren't phosphorylated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Mitotic Anaphase Signaling by Wnt M Phase APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane Degradation of beta-catenin by the destruction complex S37 mutants of beta-catenin aren't phosphorylated RNF mutants show enhanced WNT signaling and proliferation S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling XAV939 inhibits tankyrase, stabilizing AXIN Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling CTLA4 inhibitory signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Cell Cycle, Mitotic Platelet homeostasis deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT Platelet sensitization by LDL AMER1 mutants destabilize the destruction complex Resolution of Sister Chromatid Cohesion deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS			Response to antineoplastic agents ( 21659360)
Protein-Protein Interactions		3 interactors: APP IPO5 PPP2R5E	8 interactors: APP BHLHB9 CHEK2 PPP2CA PPP2R1B RACGAP1 SGOL1 SMAD9
Entrez ID		80823	5529
HPRD ID		10028	09040
Ensembl ID		ENSG00000198908
Uniprot IDs		Q6PI77	B7Z5X1 B7Z7C0 B7ZAW5 B7ZKK9 J3KQN6 Q16537 Q59EK0
PDB IDs
Enriched GO Terms of Interacting Partners?		Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Regulation Of Catalytic Activity Neuron Remodeling Ribosomal Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus	Mitotic Spindle Assembly Mitotic Cell Cycle Process Mitotic Cell Cycle Microtubule-based Process Mitotic Spindle Organization Mitotic Nuclear Division Apoptotic Process Programmed Cell Death Cell Cycle Process Reproduction Developmental Process Cell Death Death Cell Division Spindle Assembly Microtubule Cytoskeleton Organization Signal Transduction Involved In Intra-S DNA Damage Checkpoint Cytokinesis, Initiation Of Separation Actomyosin Contractile Ring Assembly Regulation Of Synapse Structure Or Activity Regulation Of Cell Cycle Process Cell Cycle Synaptic Growth At Neuromuscular Junction Regulation Of Receptor Activity Regulation Of DNA Replication Spindle Organization Collateral Sprouting In Absence Of Injury Regulation Of Cell Differentiation Anatomical Structure Development Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Centriole-centriole Cohesion Intracellular Signal Transduction Meiotic Cell Cycle Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Component Assembly Axon Choice Point Recognition Mitotic Spindle Midzone Assembly Regulation Of Cell Development Positive Regulation Of Metabolic Process Positive Regulation Of Cell Cycle Process Mitotic Spindle Elongation Mitotic Cytokinetic Process Mullerian Duct Regression Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Neuron Remodeling Mitotic Nuclear Envelope Reassembly
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