IST1 and SPAST

Number of citations of the paper that reports this interaction (PMID 20719964)
16

Data Source:
BioGRID (two hybrid, pull down)

		IST1	SPAST
Gene Name		increased sodium tolerance 1 homolog (yeast)	spastin
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum-Golgi Intermediate Compartment Centrosome Cytosol Cytoplasmic Membrane-bounded Vesicle Midbody Extracellular Vesicular Exosome Flemming Body	Nucleus Cytoplasm Endosome Endoplasmic Reticulum Centrosome Spindle Microtubule Microtubule Cytoskeleton Integral Component Of Membrane Midbody Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein Domain Specific Binding Protein Complex Binding MIT Domain Binding	Protein Binding ATP Binding Microtubule Binding Microtubule-severing ATPase Activity Alpha-tubulin Binding Beta-tubulin Binding
	Biological Process	Cytokinesis Protein Localization Abscission Viral Release From Host Cell Establishment Of Protein Localization Positive Regulation Of Proteolysis Viral Capsid Secondary Envelopment Positive Regulation Of Collateral Sprouting Cell Division	Microtubule Bundle Formation ER To Golgi Vesicle-mediated Transport Cytokinesis, Completion Of Separation Axonogenesis Metabolic Process Positive Regulation Of Microtubule Depolymerization Cytoplasmic Microtubule Organization Protein Hexamerization Microtubule Severing Protein Homooligomerization
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: APEH ATXN1 CAPN7 SPAST UBQLN1	4 interactors: CHMP1B IST1 RTN1 SSNA1
Entrez ID		9798	6683
HPRD ID		13784	05044
Ensembl ID			ENSG00000021574
Uniprot IDs		B4DXC9 J3QLU7 P53990	E5KRP5 E5KRP6 Q9UBP0
PDB IDs		3FRR 3FRS	3EAB 3VFD
Enriched GO Terms of Interacting Partners?			Cytokinesis Viral Capsid Secondary Envelopment Cell Cycle Process Viral Release From Host Cell Cell Cycle Ciliary Receptor Clustering Involved In Smoothened Signaling Pathway Abscission Positive Regulation Of Collateral Sprouting Regulation Of Mitotic Spindle Assembly Regulation Of Spindle Assembly Cell Division Protein Localization Regulation Of Mitotic Spindle Organization Cell Separation After Cytokinesis Mitotic Metaphase Plate Congression Mitotic Cell Cycle Process Metaphase Plate Congression Mitotic Cell Cycle Intraciliary Transport Regulation Of Centrosome Duplication Establishment Of Chromosome Localization Regulation Of Centrosome Cycle Receptor Clustering
Tagcloud ?			accounts autosomal backgroundhereditary cassette conclusionsspg4 determinants earlier families hsp hsps inverted limbs mark mark0 mark18 mark19 methodsa paraplegias preservation question resultsmutations spg31 spg3a spg4 taiwanese weakness
Tagcloud (Difference) ?			accounts autosomal backgroundhereditary cassette conclusionsspg4 determinants earlier families hsp hsps inverted limbs mark mark0 mark18 mark19 methodsa paraplegias preservation question resultsmutations spg31 spg3a spg4 taiwanese weakness
Tagcloud (Intersection) ?