CDA and ZNF598

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		CDA	ZNF598
Description		cytidine deaminase	zinc finger protein 598, E3 ubiquitin ligase
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Secretory Granule Lumen Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Cytoplasm Cytosol Cytosolic Ribosome
	Molecular Function	Nucleoside Binding Catalytic Activity Cytidine Deaminase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	RNA Binding Protein Binding Zinc Ion Binding Transferase Activity Ribosome Binding Metal Ion Binding Ubiquitin-protein Transferase Regulator Activity Ubiquitin Protein Ligase Activity Protein-RNA Adaptor Activity Stalled Ribosome Sensor Activity
	Biological Process	Pyrimidine-containing Compound Salvage Cytosine Metabolic Process UMP Salvage Response To Cycloheximide Nucleobase-containing Small Molecule Metabolic Process Cellular Response To External Biotic Stimulus Pyrimidine-containing Compound Metabolic Process Carbohydrate Derivative Metabolic Process	Regulation Of Translation Protein Monoubiquitination Protein Ubiquitination Ribosome Disassembly Negative Regulation Of Translational Initiation Protein K63-linked Ubiquitination Rescue Of Stalled Ribosome Ribosome-associated Ubiquitin-dependent Protein Catabolic Process
Pathways		Neutrophil degranulation Pyrimidine salvage	ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs		1-Beta-Ribofuranosyl-1,3-Diazepinone Cedazuridine
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Basophil percentage of white cells ( 32888494) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		18 interacting genes: ADAT3 ARRDC3 DDIT4L FNDC11 FOXN1 GORASP2 INCA1 KPNA2 KRTAP6-1 KRTAP8-1 LNX1 NTAQ1 PLEKHB2 PSMA1 PTGER3 SDCBP ZBTB24 ZNF598	8 interacting genes: CDA CXCL8 DBN1 RPS10 RPS20 RPS3 UBE2D1 UBE2D3
Entrez ID		978	90850
HPRD ID		11744	11732
Ensembl ID		ENSG00000158825	ENSG00000167962
Uniprot IDs		P32320	A0AAG2UWE8 Q86UK7
PDB IDs		1MQ0
Enriched GO Terms of Interacting Partners?			Cytosolic Small Ribosomal Subunit Cytosolic Ribosome Cytoplasmic Translation Structural Constituent Of Ribosome Small Ribosomal Subunit Ribosome Ubiquitin Conjugating Enzyme Activity Regulation Of Cell Communication Regulation Of Signaling Response To TNF Agonist Oxidized Pyrimidine DNA Binding Negative Regulation Of BMP Signaling Pathway Translation Cellular Response To External Biotic Stimulus Cytosine Metabolic Process Cell Communication By Chemical Coupling Interleukin-8 Receptor Binding Positive Regulation Of Base-excision Repair Ribonucleoprotein Complex Cellular Response To Tumor Necrosis Factor Nucleoside Binding Regulation Of Signal Transduction Positive Regulation Of Endodeoxyribonuclease Activity Protein K48-linked Ubiquitination Regulation Of BMP Signaling Pathway Positive Regulation Of Receptor Localization To Synapse Response To Tumor Necrosis Factor Positive Regulation Of Deoxyribonuclease Activity NF-kappaB Complex Regulation Of Base-excision Repair Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Cycloheximide Negative Regulation Of Macromolecule Biosynthetic Process UMP Salvage Pyrimidine Ribonucleotide Salvage Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Biosynthetic Process Oxidized Purine DNA Binding Regulation Of Endodeoxyribonuclease Activity Ubiquitin-like Protein Conjugating Enzyme Binding Supercoiled DNA Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
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