SETD1A and WDR5

Number of citations of the paper that reports this interaction (PMID 22266653)
13

Data Source:
BioGRID (pull down, affinity chromatography technology, unspecified method)

		SETD1A	WDR5
Gene Name		SET domain containing 1A	WD repeat domain 5
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nuclear Speck Histone Methyltransferase Complex Set1C/COMPASS Complex	Histone Acetyltransferase Complex Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Histone Methyltransferase Complex Set1C/COMPASS Complex MLL1 Complex
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding Histone Methyltransferase Activity (H3-K4 Specific)	Protein Binding Histone Methyltransferase Activity (H3-K4 Specific) Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Histone Acetyltransferase Activity (H4-K16 Specific)
	Biological Process	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Stem Cell Maintenance Histone H3-K4 Methylation Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Stem Cell Proliferation	Skeletal System Development Chromatin Organization Transcription, DNA-templated Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H3 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Histone H3-K4 Methylation
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines	Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines HATs acetylate histones RMTs methylate histone arginines
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: DPY30 EP300 HIST1H3A HIST2H3C LBP TP53 WDR5	23 interactors: APP ATN1 CHD8 HIST1H1C HIST4H4 HSF2 IKBKG KMT2A KMT2B KMT2C MBIP MLLT1 POU5F1 PRMT5 PRNP RUSC1-AS1 SETD1A SETD1B SRPK2 SSX2IP TERF2IP TP53 ZXDC
Entrez ID		9739	11091
HPRD ID		13795	10614
Ensembl ID		ENSG00000099381	ENSG00000196363
Uniprot IDs		O15047	P61964
PDB IDs		3S8S 3UVN 4EWR	2CNX 2CO0 2G99 2G9A 2GNQ 2H13 2H14 2H68 2H6K 2H6N 2H6Q 2H9L 2H9M 2H9N 2H9P 2O9K 3EG6 3EMH 3MXX 3N0D 3N0E 3P4F 3PSL 3SMR 3UR4 3UVK 3UVL 3UVM 3UVN 3UVO 4A7J 4ERQ 4ERY 4ERZ 4ES0 4ESG 4EWR 4GM3 4GM8 4IA9
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromosome Organization Methylation DNA Methylation On Cytosine Chromatin Silencing At RDNA Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Histone H3-K4 Methylation Peptidyl-lysine Modification Chromatin Silencing Gene Expression Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Protein Deacetylation Histone H4 Acetylation DNA Methylation Negative Regulation Of Transcription, DNA-templated Histone Modification Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Blood Coagulation Hemostasis Negative Regulation Of Gene Expression, Epigenetic Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Somitogenesis Regulation Of RNA Metabolic Process DNA Modification Negative Regulation Of Gene Expression Histone H2B Acetylation Nucleobase-containing Compound Metabolic Process Histone Lysine Methylation Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Somite Development Peptidyl-lysine Methylation Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Gene Silencing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process ER-nucleus Signaling Pathway Regulation Of Gene Expression Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Regulation Of Body Fluid Levels Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Histone Acetylation Segmentation	Gene Expression Chromatin Organization Regulation Of RNA Metabolic Process Chromosome Organization RNA Metabolic Process Transcription, DNA-templated Regulation Of Gene Expression Histone H3-K4 Methylation RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone Methylation Histone Modification Chromatin Modification Cellular Nitrogen Compound Metabolic Process Protein Methylation Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Histone Lysine Methylation Peptidyl-lysine Methylation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Organelle Organization Methylation Peptidyl-lysine Modification Positive Regulation Of Gene Expression Regulation Of Chromosome Organization Positive Regulation Of Transcription, DNA-templated Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Peptidyl-amino Acid Modification Regulation Of Transcription From RNA Polymerase II Promoter Neuron Apoptotic Process Cellular Component Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter Neuron Death Cellular Metabolic Process Histone H3-K4 Trimethylation DNA Conformation Change Regulation Of Organelle Organization Cellular Copper Ion Homeostasis Regulation Of Fibroblast Apoptotic Process
Tagcloud ?		accomplish ash2l assembled assembles catalyzes confer dimethylation dpy enzymatic evolutionary evolved h3k4 inputs metazoan methyltransferases missing mll1 mll3 monomethtranferase monomethylation mutagenesis rbbp5 reconstituted set1 substitutions trimethylation trithorax wdr5 wrad	acidic allosterically ash2l box compass composed concave dpy30 erythroid forming heterodimer interface kmt2 lysine methyltransferase methyltransferases mll1 mutational rbbp5 referred ryanodine set1 spia spry stimulates switch trithorax trxg wrad
Tagcloud (Difference) ?		accomplish assembled assembles catalyzes confer dimethylation dpy enzymatic evolutionary evolved h3k4 inputs metazoan missing mll3 monomethtranferase monomethylation mutagenesis reconstituted substitutions trimethylation	acidic allosterically box compass composed concave dpy30 erythroid forming heterodimer interface kmt2 lysine methyltransferase mutational referred ryanodine spia spry stimulates switch trxg
Tagcloud (Intersection) ?		ash2l methyltransferases mll1 rbbp5 set1 trithorax wdr5 wrad