USF1 and USF2

Number of citations of the paper that reports this interaction (PubMedID 9053857)
0

Data Source:
HPRD (in vivo, in vitro)

		USF1	USF2
Description		upstream transcription factor 1	upstream transcription factor 2, c-fos interacting
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Golgi Apparatus	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Protein-containing Complex Binding Protein Heterodimerization Activity Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Response To Hypoxia Glucose Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To UV Glucose Mediated Signaling Pathway Late Viral Transcription Cellular Response To Insulin Stimulus Glucose Homeostasis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Carbon Catabolite Regulation Of Transcription Negative Regulation Of Fibrinolysis Lipid Homeostasis Cellular Response To Glucose Stimulus	Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription By RNA Polymerase II Lactation Glucose Mediated Signaling Pathway Late Viral Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Lipid Homeostasis Cellular Response To Glucose Stimulus
Pathways		Estrogen-dependent gene expression Regulation of MITF-M-dependent genes involved in pigmentation	Estrogen-dependent gene expression
Drugs
Diseases		Familial combined hyperlipidemia (FCHL)
GWAS		Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 23128233) Night sleep phenotypes ( 27126917)	Adverse response to drug ( 30420678) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252 32888494) Red cell distribution width ( 27863252 28957414 32888494)
Interacting Genes		20 interacting genes: APP ESR1 FBXO7 FOS FOSL1 GTF2I HDAC9 HOMEZ LAP3 MAP3K7CL NFYA PLEKHF2 PPARGC1A PRKDC SNW1 TAOK2 TCF3 TCFL5 TRAF2 USF2	10 interacting genes: BRCA1 EP300 FOS LZTS2 MAF NFYA PPARGC1A RELA TEAD2 USF1
Entrez ID		7391	7392
HPRD ID		01880	02668
Ensembl ID		ENSG00000158773	ENSG00000105698
Uniprot IDs		A0A0S2Z4U5 P22415	Q15853
PDB IDs		1AN4	8IA3
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Chromatin Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Positive Regulation Of RNA Metabolic Process Nucleoplasm Nucleus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of MiRNA Transcription Cellular Response To Oxygen-containing Compound Regulation Of MiRNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Transcription Regulator Complex Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Transcription By RNA Polymerase II Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex B Cell Lineage Commitment Regulation Of Developmental Process Regulation Of Primary Metabolic Process Mononuclear Cell Differentiation Leukocyte Activation Immunoglobulin V(D)J Recombination Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Leukocyte Differentiation Enzyme Binding Cell Activation RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process RNA Metabolic Process DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Lymphocyte Activation Mitogen-activated Protein Kinase Kinase Kinase Binding Protein-containing Complex	Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Positive Regulation Of RNA Metabolic Process DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Response To Nutrient Levels Nucleobase-containing Compound Biosynthetic Process DNA Binding Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Protein-DNA Complex Nucleic Acid Metabolic Process Transcription Coactivator Binding Response To Radiation RNA Metabolic Process Sequence-specific DNA Binding Cellular Response To Oxygen-containing Compound Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Cis-regulatory Region Binding Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Chromatin DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleobase-containing Compound Metabolic Process Cellular Response To Tumor Necrosis Factor Response To Light Stimulus Regulation Of Nucleobase-containing Compound Metabolic Process Response To Tumor Necrosis Factor Glucose Metabolic Process Double-stranded DNA Binding RNA Polymerase II Transcription Regulator Complex RNA Polymerase II Core Promoter Sequence-specific DNA Binding Response To Nutrient Response To UV DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Muscle Stretch Hexose Metabolic Process Response To Insulin Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Vascular Endothelial Growth Factor Production
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