MIR34A and LIN28B

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR34A	LIN28B
Description		microRNA 34a	lin-28 RNA binding posttranscriptional regulator B
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Exosome Extracellular Vesicle	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Damage Response Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Lipid Storage Negative Regulation Of Angiogenesis Negative Regulation Of Chemokine Production Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Transmembrane Transport MiRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Cholesterol Homeostasis Response To Axon Injury Negative Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Differentiation Regulation Of Cell Cycle Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Vascular Wound Healing Triglyceride Homeostasis Cellular Response To Hypoxia Negative Regulation Of IP-10 Production Negative Regulation Of Smooth Muscle Cell Chemotaxis Negative Regulation Of Calcium Ion Import Programmed Cell Death In Response To Reactive Oxygen Species Positive Regulation Of Blood Vessel Endothelial Cell Differentiation Negative Regulation Of Amyloid-beta Clearance Negative Regulation Of Sprouting Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Connective Tissue Replacement Negative Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Cellular Senescence	MiRNA Catabolic Process Post-transcriptional Regulation Of Gene Expression Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing RNA 3'-end Processing RNA Destabilization Positive Regulation Of MiRNA Catabolic Process Negative Regulation Of Pre-miRNA Processing Negative Regulation Of Primary MiRNA Processing
Pathways
Drugs
Diseases
GWAS		Height ( 31562340) Lean body mass ( 28552196)	Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Age at menarche ( 30044860) Age at voice drop ( 27182965) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Digit length ratio ( 20303062 29659830) Digit length ratio (left hand) ( 29659830) Digit length ratio (right hand) ( 29659830) Height ( 18391951 28552196 18391950 25429064 25282103 20881960 23563607) Hip circumference adjusted for BMI ( 25673412 34021172) Insomnia ( 32332799) Intraocular pressure ( 29617998 30054594) Major depressive disorder ( 27479909) Menarche (age at onset) ( 21102462 19448623 29773799 19448622 23667675 19448620 27182965 25231870) Menarche and menopause (age at onset) ( 19448621) Metabolite levels ( 23823483) Neuroblastoma ( 22941191) Pubertal anthropometrics ( 23449627) Puberty onset ( 24770850) Puberty onset (breast development) ( 24770850) Schizophrenia ( 28991256 30285260) Sporadic neuroblastoma ( 28545128) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in inactive individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 25673412 34021172) White blood cell count ( 32888494)
Interacting Genes		102 interacting genes: ADARB1 AIMP1 AIMP2 APOBEC3B AQR ATXN2L C1QBP CDC5L CELF1 CPSF1 CPSF6 DARS1 DDX1 DDX21 DDX3X DDX3Y DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ESRP1 FAM98A FAM98B FIP1L1 FUS G3BP2 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 MYEF2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PDCD11 PGAM5 PLOD1 PRMT1 PTBP1 PTBP3 PUF60 PUM1 PURA QARS1 RARS1 RBFOX2 RBM12B RBM14 RBM4 RTCB SART3 SF1 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SYMPK SYNCRIP TAF15 TIAL1 TRA2A TRA2B TRIM25 TRMT1L U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZNF346	46 interacting genes: AURKB KAT2B MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR143 MIR145 MIR15A MIR19B1 MIR200A MIR205 MIR206 MIR221 MIR25 MIR29A MIR29B1 MIR29B2 MIR31 MIR34A MIR34B MIR429 MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I OTUD6B
Entrez ID		407040	389421
HPRD ID			13366
Ensembl ID		ENSG00000284357	ENSG00000187772
Uniprot IDs			A0A1B0GVD3 Q6ZN17
PDB IDs			4A4I
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Metabolic Process RNA Processing Nucleic Acid Metabolic Process MRNA Metabolic Process RNA Splicing MRNA Processing Nucleobase-containing Compound Metabolic Process MRNA Binding Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleus Regulation Of RNA Splicing Nucleoplasm Regulation Of MRNA Metabolic Process Aminoacyl-tRNA Synthetase Multienzyme Complex Spliceosomal Complex Cytoplasmic Stress Granule Catalytic Step 2 Spliceosome Ribonucleoprotein Complex Post-transcriptional Regulation Of Gene Expression MRNA 3'-UTR Binding Regulation Of MRNA Processing Regulation Of Translation Regulation Of MRNA Splicing, Via Spliceosome MiRNA Binding Negative Regulation Of MRNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Regulation Of Macromolecule Metabolic Process TRNA Aminoacylation Negative Regulation Of Translation TRNA Metabolic Process Negative Regulation Of RNA Catabolic Process Regulation Of RNA Stability Negative Regulation Of MRNA Catabolic Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process RNA Stabilization Regulation Of MRNA Stability Ligase Activity U2 SnRNP MRNA Stabilization Regulation Of Alternative MRNA Splicing, Via Spliceosome Spliceosomal Complex Assembly Positive Regulation Of Cytoplasmic Translation	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization MRNA 3'-UTR Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Extracellular Vesicle Negative Regulation Of Translation MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Metabolic Process Regulation Of Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Translation Negative Regulation Of Cell Migration Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of MRNA Metabolic Process Extracellular Space Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Cell Motility Positive Regulation Of Catabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Locomotion Negative Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?