CD70 and ATP5F1D

Data Source: HiPPIP (Novel)

		CD70	ATP5F1D
Name		CD70 molecule	ATP synthase F1 subunit delta
Structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Extracellular Exosome	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Proton-transporting ATP Synthase Complex
	Molecular Function	Tumor Necrosis Factor Receptor Binding Protein Binding Receptor Ligand Activity	Structural Molecule Activity Protein Binding ATP Binding ADP Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism
	Biological Process	T Cell Mediated Immunity Immune Response B Cell Mediated Immunity Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation B Cell Proliferation Positive Regulation Of T Cell Proliferation T Cell Activation Lymphocyte Proliferation Adaptive Immune Memory Response Involving T Cells And B Cells Extrinsic Apoptotic Signaling Pathway CD27 Signaling Pathway	ATP Biosynthetic Process Monoatomic Ion Transport Aerobic Respiration Proton Motive Force-driven ATP Synthesis Mitochondrial Proton-transporting ATP Synthase Complex Assembly Proton Motive Force-driven Mitochondrial ATP Synthesis Response To Copper Ion Proton Transmembrane Transport
Pathways		TNFs bind their physiological receptors	Formation of ATP by chemiosmotic coupling Cristae formation
Drugs		Cusatuzumab	Isoflurane Desflurane
GWAS		Asthma ( 32296059 ) Heel bone mineral density x serum urate levels interaction ( 34046847 )	No GWAS studies recorded
Interacting Genes		2 interacting genes: CD27 ELOVL4	9 interacting genes: EXOSC3 KRTAP10-8 MDFI NBPF19 NOTCH2NLA SRSF11 TRIM55 TRIM63 TTN
Entrez ID		970	513
HPRD ID		18515	04397
Ensembl ID		ENSG00000125726	ENSG00000099624
Uniprot IDs		A0A0U5JA32 P32970	P30049
PDB IDs		7KX0	8H9F 8H9J 8H9M 8H9Q 8H9S 8H9T 8H9U 8H9V 8KHF 8KI3
GO Terms Enriched among Interactors		Nucleoside Phosphate Biosynthetic Process Proton-transporting ATP Synthase Complex Assembly Purine-containing Compound Biosynthetic Process Mitochondrial Proton-transporting ATP Synthase Complex Assembly Adaptive Immune Memory Response Adaptive Immune Memory Response Involving T Cells And B Cells CD27 Signaling Pathway Fatty Acid Elongation, Monounsaturated Fatty Acid Unsaturated Fatty Acid Metabolic Process Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Phylloquinone Catabolic Process Menaquinone Metabolic Process Menaquinone Catabolic Process Vitamin K Catabolic Process Alkane 1-monooxygenase Activity Fatty Acid Metabolic Process Fatty Acid Elongation, Saturated Fatty Acid Small Molecule Metabolic Process G Protein-coupled Photoreceptor Activity Very Long-chain Fatty Acid Biosynthetic Process Fatty Acid Elongation Vitamin K Metabolic Process Proton-transporting ATP Synthase Activity, Rotational Mechanism Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Purine-containing Compound Metabolic Process Positive Regulation Of B Cell Differentiation Long-chain Fatty-acyl-CoA Biosynthetic Process Monocarboxylic Acid Metabolic Process Ketone Catabolic Process Proton-transporting ATP Synthase Complex Organophosphate Biosynthetic Process Nucleoside Phosphate Metabolic Process Negative Regulation Of T Cell Apoptotic Process Long-chain Fatty-acyl-CoA Metabolic Process Detection Of Visible Light Vitamin Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Fatty-acyl-CoA Biosynthetic Process Nucleobase-containing Small Molecule Metabolic Process Response To Copper Ion Negative Regulation Of Lymphocyte Apoptotic Process Regulation Of B Cell Differentiation Very Long-chain Fatty Acid Metabolic Process Prostanoid Metabolic Process Prostaglandin Metabolic Process ADP Binding Immunoglobulin Mediated Immune Response Regulation Of T Cell Apoptotic Process Carboxylic Acid Metabolic Process	M Band