CD70

Name	CD70 molecule
Structure
Novel Interactors	2 novel interactors: ATP5F1D CYP4F8
Interactors	2 interactors: CD27 ELOVL4
GO Annotations	Cellular Component	Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Tumor Necrosis Factor Receptor Binding Protein Binding Receptor Ligand Activity
	Biological Process	T Cell Mediated Immunity Immune Response B Cell Mediated Immunity Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation B Cell Proliferation Positive Regulation Of T Cell Proliferation T Cell Activation Lymphocyte Proliferation Adaptive Immune Memory Response Involving T Cells And B Cells Extrinsic Apoptotic Signaling Pathway CD27 Signaling Pathway
Pathways	TNFs bind their physiological receptors
Drugs	Cusatuzumab
GWAS	Asthma ( 32296059 ) Heel bone mineral density x serum urate levels interaction ( 34046847 )
Entrez ID	970
HPRD ID	18515
Ensembl ID	ENSG00000125726
Uniprot IDs	A0A0U5JA32 P32970
PDB IDs	7KX0
GO Terms Enriched among Interactors ?	Nucleoside Phosphate Biosynthetic Process Proton-transporting ATP Synthase Complex Assembly Purine-containing Compound Biosynthetic Process Mitochondrial Proton-transporting ATP Synthase Complex Assembly Adaptive Immune Memory Response Adaptive Immune Memory Response Involving T Cells And B Cells CD27 Signaling Pathway Fatty Acid Elongation, Monounsaturated Fatty Acid Unsaturated Fatty Acid Metabolic Process Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Phylloquinone Catabolic Process Menaquinone Metabolic Process Menaquinone Catabolic Process Vitamin K Catabolic Process Alkane 1-monooxygenase Activity Fatty Acid Metabolic Process Fatty Acid Elongation, Saturated Fatty Acid Small Molecule Metabolic Process G Protein-coupled Photoreceptor Activity Very Long-chain Fatty Acid Biosynthetic Process Fatty Acid Elongation Vitamin K Metabolic Process Proton-transporting ATP Synthase Activity, Rotational Mechanism Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Purine-containing Compound Metabolic Process Positive Regulation Of B Cell Differentiation Long-chain Fatty-acyl-CoA Biosynthetic Process Monocarboxylic Acid Metabolic Process Ketone Catabolic Process Proton-transporting ATP Synthase Complex Organophosphate Biosynthetic Process Nucleoside Phosphate Metabolic Process Negative Regulation Of T Cell Apoptotic Process Long-chain Fatty-acyl-CoA Metabolic Process Detection Of Visible Light Vitamin Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Fatty-acyl-CoA Biosynthetic Process Nucleobase-containing Small Molecule Metabolic Process Response To Copper Ion Negative Regulation Of Lymphocyte Apoptotic Process Regulation Of B Cell Differentiation Very Long-chain Fatty Acid Metabolic Process Prostanoid Metabolic Process Prostaglandin Metabolic Process ADP Binding Immunoglobulin Mediated Immune Response Regulation Of T Cell Apoptotic Process Carboxylic Acid Metabolic Process