CD70 and CYP4F8

Data Source: HiPPIP (Novel)

		CD70	CYP4F8
Name		CD70 molecule	cytochrome P450 family 4 subfamily F member 8
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Tumor Necrosis Factor Receptor Binding Protein Binding Receptor Ligand Activity	Monooxygenase Activity Iron Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Alkane 1-monooxygenase Activity Heme Binding Metal Ion Binding
	Biological Process	T Cell Mediated Immunity Immune Response B Cell Mediated Immunity Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation B Cell Proliferation Positive Regulation Of T Cell Proliferation T Cell Activation Lymphocyte Proliferation Adaptive Immune Memory Response Involving T Cells And B Cells Extrinsic Apoptotic Signaling Pathway CD27 Signaling Pathway	Lipid Metabolic Process Fatty Acid Metabolic Process Icosanoid Metabolic Process Prostaglandin Metabolic Process Arachidonate Metabolic Process Menaquinone Catabolic Process Phylloquinone Catabolic Process
Pathways		TNFs bind their physiological receptors	Fatty acids Eicosanoids Synthesis of Leukotrienes (LT) and Eoxins (EX)
Drugs		Cusatuzumab	None
GWAS		Asthma ( 32296059 ) Heel bone mineral density x serum urate levels interaction ( 34046847 )	Inflammatory biomarkers ( 22228203 )
Interacting Genes		2 interacting genes: CD27 ELOVL4	None recorded
Entrez ID		970	11283
HPRD ID		18515	08518
Ensembl ID		ENSG00000125726	ENSG00000186526
Uniprot IDs		A0A0U5JA32 P32970	P98187
PDB IDs		7KX0	Not available
GO Terms Enriched among Interactors		Nucleoside Phosphate Biosynthetic Process Proton-transporting ATP Synthase Complex Assembly Purine-containing Compound Biosynthetic Process Mitochondrial Proton-transporting ATP Synthase Complex Assembly Adaptive Immune Memory Response Adaptive Immune Memory Response Involving T Cells And B Cells CD27 Signaling Pathway Fatty Acid Elongation, Monounsaturated Fatty Acid Unsaturated Fatty Acid Metabolic Process Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Phylloquinone Catabolic Process Menaquinone Metabolic Process Menaquinone Catabolic Process Vitamin K Catabolic Process Alkane 1-monooxygenase Activity Fatty Acid Metabolic Process Fatty Acid Elongation, Saturated Fatty Acid Small Molecule Metabolic Process G Protein-coupled Photoreceptor Activity Very Long-chain Fatty Acid Biosynthetic Process Fatty Acid Elongation Vitamin K Metabolic Process Proton-transporting ATP Synthase Activity, Rotational Mechanism Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Purine-containing Compound Metabolic Process Positive Regulation Of B Cell Differentiation Long-chain Fatty-acyl-CoA Biosynthetic Process Monocarboxylic Acid Metabolic Process Ketone Catabolic Process Proton-transporting ATP Synthase Complex Organophosphate Biosynthetic Process Nucleoside Phosphate Metabolic Process Negative Regulation Of T Cell Apoptotic Process Long-chain Fatty-acyl-CoA Metabolic Process Detection Of Visible Light Vitamin Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Fatty-acyl-CoA Biosynthetic Process Nucleobase-containing Small Molecule Metabolic Process Response To Copper Ion Negative Regulation Of Lymphocyte Apoptotic Process Regulation Of B Cell Differentiation Very Long-chain Fatty Acid Metabolic Process Prostanoid Metabolic Process Prostaglandin Metabolic Process ADP Binding Immunoglobulin Mediated Immune Response Regulation Of T Cell Apoptotic Process Carboxylic Acid Metabolic Process	Adaptive Immune Memory Response CD27 Signaling Pathway Adaptive Immune Memory Response Involving T Cells And B Cells Tumor Necrosis Factor Receptor Binding B Cell Mediated Immunity T Cell Mediated Immunity B Cell Proliferation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Lymphocyte Mediated Immunity Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation T Cell Proliferation Leukocyte Proliferation Receptor Ligand Activity Positive Regulation Of T Cell Proliferation Mononuclear Cell Proliferation Extrinsic Apoptotic Signaling Pathway Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Positive Regulation Of Leukocyte Proliferation Regulation Of T Cell Proliferation B Cell Activation Regulation Of Mononuclear Cell Proliferation Positive Regulation Of T Cell Activation Adaptive Immune Response Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Leukocyte Proliferation T Cell Activation Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Apoptotic Signaling Pathway Positive Regulation Of Cell Activation Immune Effector Process Regulation Of T Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Cytokine-mediated Signaling Pathway Lymphocyte Activation