ATP5F1D and TTN

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		ATP5F1D	TTN
Description		ATP synthase F1 subunit delta	titin
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Proton-transporting ATP Synthase Complex	Condensed Nuclear Chromosome Extracellular Region Nucleus Cytoplasm Cytosol Striated Muscle Thin Filament Actin Cytoskeleton Z Disc M Band I Band Protein-containing Complex Extracellular Exosome Titin-telethonin Complex
	Molecular Function	Structural Molecule Activity Protein Binding ATP Binding ADP Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism	Nucleotide Binding Protease Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Structural Molecule Activity Calcium Ion Binding Protein Binding Calmodulin Binding ATP Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Kinase Activity Transferase Activity Protein Kinase Regulator Activity Enzyme Binding Protein Kinase Binding Telethonin Binding Identical Protein Binding Protein Homodimerization Activity Actinin Binding Metal Ion Binding Actin Filament Binding Muscle Alpha-actinin Binding Structural Molecule Activity Conferring Elasticity Protein Serine Kinase Activity
	Biological Process	ATP Biosynthetic Process Monoatomic Ion Transport Aerobic Respiration Proton Motive Force-driven ATP Synthesis Mitochondrial Proton-transporting ATP Synthase Complex Assembly Proton Motive Force-driven Mitochondrial ATP Synthesis Response To Copper Ion Proton Transmembrane Transport	Skeletal Muscle Contraction Cardiac Muscle Hypertrophy Muscle Contraction Striated Muscle Contraction Mitotic Chromosome Condensation Positive Regulation Of Gene Expression Protein Kinase A Signaling Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Detection Of Muscle Stretch Sarcomere Organization Sarcomerogenesis Positive Regulation Of Protein Secretion Response To Calcium Ion Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Development Cardiac Muscle Contraction
Pathways		Formation of ATP by chemiosmotic coupling Cristae formation	Platelet degranulation Striated Muscle Contraction
Drugs		Isoflurane Desflurane
Diseases			Dilated cardiomyopathy (DCM) Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Hypertrophic cardiomyopathy (HCM)
GWAS			Atrial fibrillation ( 30061737 29892015 29290336) Bone mineral density (hip) ( 30172743) Breast size ( 22747683) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Left ventricular ejection fraction ( 32382064 33495596) Left ventricular end-diastolic volume ( 32382064 33495596) Left ventricular end-systolic volume ( 32382064 33495596) Left ventricular global circumferential strain ( 33495596) Left ventricular global radial strain ( 33495596) Left ventricular mass ( 33495596) PR interval ( 32439900 30046033) QT interval ( 24952745 20031603 29874175 29213071) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183) Refractive error ( 32231278) Resting heart rate ( 27798624) Sick sinus syndrome ( 33580673) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)
Interacting Genes		9 interacting genes: EXOSC3 KRTAP10-8 MDFI NBPF19 NOTCH2NLA SRSF11 TRIM55 TRIM63 TTN	83 interacting genes: ABLIM1 ABLIM2 ACTA1 ACTN1 ACTN2 ACTN3 ACTN4 AMOT ANK1 ANKRD1 ANKRD2 ANKRD23 ANKRD28 ASH2L ATP5F1D C1QTNF9 CALM1 CAPN3 CCT6A CHD4 CLIP4 CRYAB DNAJB5 DNAJB6 ENO1 ENO3 EXOSC10 FBXO32 FHL1 FHL2 FILNC1 FLNA FN1 FNDC3B GABARAP HSPA1B HSPB2 ITGB1BP2 ITGB5 JPH1 LIMS1 MAP1LC3A MAP1LC3B MAPK1 MAST2 MYBPC1 MYBPC2 MYBPC3 MYBPH MYCBP2 MYH9 MYOM1 MYOM2 MYPN NBR1 NEB NEK9 NEO1 OBSCN PARD3 PHGDH POMP PYGM RNF167 RPL12 RYR1 SF1 SGCG SH3GLB1 SQSTM1 SRPK2 STUB1 TAB2 TCAP TRIM54 TRIM55 TRIM63 TSC22D2 TTC3 UBE2I UGP2 USP7 VAV2
Entrez ID		513	7273
HPRD ID		04397	01787
Ensembl ID		ENSG00000099624	ENSG00000155657
Uniprot IDs		P30049	A0A0A0MRA3 Q8WZ42
PDB IDs		8H9F 8H9J 8H9M 8H9Q 8H9S 8H9T 8H9U 8H9V 8KHF 8KI3	1BPV 1G1C 1NCT 1NCU 1TIT 1TIU 1TKI 1TNM 1TNN 1WAA 1YA5 2A38 2BK8 2F8V 2ILL 2J8H 2J8O 2NZI 2RQ8 2WP3 2WWK 2WWM 2Y9R 3B43 3KNB 3LCY 3LPW 3PUC 3Q5O 3QP3 4C4K 4JNW 4O00 4QEG 4UOW 5BS0 5JDD 5JDE 5JDJ 5JOE 6DL4 6FWX 6H4L 6HCI 6I0Y 6SDB 6YGN 7AHS 7NIP 8BNQ 8BVO 8BW6 8BXR 8G4L 8OIY 8OMW 8OQ9 8ORL 8OS3 8OSD 8OT5 8OTY 8OVU 8P35
Enriched GO Terms of Interacting Partners?		M Band	Z Disc Structural Constituent Of Muscle M Band Titin Binding Sarcomere Organization Actomyosin Structure Organization Actin Cytoskeleton Organization Sarcomere Actin Filament-based Process Cytoskeleton Organization Cytoplasm Cytosol Myosin Filament I Band Muscle Structure Development Muscle Organ Development Actin Binding Actin Cytoskeleton Pseudopodium Transmembrane Transporter Binding Muscle Cell Development Organelle Organization Myofibril Focal Adhesion Protein Binding Actin Filament Binding Integrin Binding Developmental Process Actin Filament Stress Fiber Muscle System Process Cytoskeleton Metal Ion Binding Regulation Of Intracellular Signal Transduction Muscle Contraction Regulation Of Cellular Component Organization Cellular Response To Nitrogen Starvation Cell Adhesion Unfolded Protein Binding Regulation Of Muscle Contraction Titin Z Domain Binding Striated Muscle Cell Development Regulation Of Muscle System Process Contractile Muscle Fiber Protein K63-linked Ubiquitination Cell-substrate Junction Assembly Phosphatidylethanolamine Binding Cell-substrate Junction Organization Autophagosome Protein Folding
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