CYP4F8 and CD70

Data Source: HiPPIP (Novel)

		CYP4F8	CD70
Name		cytochrome P450 family 4 subfamily F member 8	CD70 molecule
Structure		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Monooxygenase Activity Iron Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Alkane 1-monooxygenase Activity Heme Binding Metal Ion Binding	Tumor Necrosis Factor Receptor Binding Protein Binding Receptor Ligand Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Icosanoid Metabolic Process Prostaglandin Metabolic Process Arachidonate Metabolic Process Menaquinone Catabolic Process Phylloquinone Catabolic Process	T Cell Mediated Immunity Immune Response B Cell Mediated Immunity Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation B Cell Proliferation Positive Regulation Of T Cell Proliferation T Cell Activation Lymphocyte Proliferation Adaptive Immune Memory Response Involving T Cells And B Cells Extrinsic Apoptotic Signaling Pathway CD27 Signaling Pathway
Pathways		Fatty acids Eicosanoids Synthesis of Leukotrienes (LT) and Eoxins (EX)	TNFs bind their physiological receptors
Drugs		None	Cusatuzumab
GWAS		Inflammatory biomarkers ( 22228203 )	Asthma ( 32296059 ) Heel bone mineral density x serum urate levels interaction ( 34046847 )
Novel Interactors		1 novel interactors: CD70	2 novel interactors: ATP5F1D CYP4F8
Interacting Genes		None recorded	2 interacting genes: CD27 ELOVL4
Entrez ID		11283	970
HPRD ID		08518	18515
Ensembl ID		ENSG00000186526	ENSG00000125726
Uniprot IDs		P98187	A0A0U5JA32 P32970
PDB IDs		Not available	7KX0
GO Terms Enriched among Interactors		Adaptive Immune Memory Response CD27 Signaling Pathway Adaptive Immune Memory Response Involving T Cells And B Cells Tumor Necrosis Factor Receptor Binding B Cell Mediated Immunity T Cell Mediated Immunity B Cell Proliferation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Lymphocyte Mediated Immunity Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation T Cell Proliferation Leukocyte Proliferation Receptor Ligand Activity Positive Regulation Of T Cell Proliferation Mononuclear Cell Proliferation Extrinsic Apoptotic Signaling Pathway Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Positive Regulation Of Leukocyte Proliferation Regulation Of T Cell Proliferation B Cell Activation Regulation Of Mononuclear Cell Proliferation Positive Regulation Of T Cell Activation Adaptive Immune Response Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Leukocyte Proliferation T Cell Activation Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Apoptotic Signaling Pathway Positive Regulation Of Cell Activation Immune Effector Process Regulation Of T Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Cytokine-mediated Signaling Pathway Lymphocyte Activation	Nucleoside Phosphate Biosynthetic Process Proton-transporting ATP Synthase Complex Assembly Purine-containing Compound Biosynthetic Process Mitochondrial Proton-transporting ATP Synthase Complex Assembly Adaptive Immune Memory Response Adaptive Immune Memory Response Involving T Cells And B Cells CD27 Signaling Pathway Fatty Acid Elongation, Monounsaturated Fatty Acid Unsaturated Fatty Acid Metabolic Process Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Phylloquinone Catabolic Process Menaquinone Metabolic Process Menaquinone Catabolic Process Vitamin K Catabolic Process Alkane 1-monooxygenase Activity Fatty Acid Metabolic Process Fatty Acid Elongation, Saturated Fatty Acid Small Molecule Metabolic Process G Protein-coupled Photoreceptor Activity Very Long-chain Fatty Acid Biosynthetic Process Fatty Acid Elongation Vitamin K Metabolic Process Proton-transporting ATP Synthase Activity, Rotational Mechanism Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Purine-containing Compound Metabolic Process Positive Regulation Of B Cell Differentiation Long-chain Fatty-acyl-CoA Biosynthetic Process Monocarboxylic Acid Metabolic Process Ketone Catabolic Process Proton-transporting ATP Synthase Complex Organophosphate Biosynthetic Process Nucleoside Phosphate Metabolic Process Negative Regulation Of T Cell Apoptotic Process Long-chain Fatty-acyl-CoA Metabolic Process Detection Of Visible Light Vitamin Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Fatty-acyl-CoA Biosynthetic Process Nucleobase-containing Small Molecule Metabolic Process Response To Copper Ion Negative Regulation Of Lymphocyte Apoptotic Process Regulation Of B Cell Differentiation Very Long-chain Fatty Acid Metabolic Process Prostanoid Metabolic Process Prostaglandin Metabolic Process ADP Binding Immunoglobulin Mediated Immune Response Regulation Of T Cell Apoptotic Process Carboxylic Acid Metabolic Process