PLEKHB2 and CFC1

		PLEKHB2	CFC1
Description		pleckstrin homology domain containing B2	cryptic, EGF-CFC family member 1
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Membrane Recycling Endosome Membrane	Extracellular Region Plasma Membrane Cell Surface Membrane Side Of Membrane
	Molecular Function	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding	Nodal Binding Activin Receptor Binding
	Biological Process	Regulation Of Cell Differentiation	Blood Vessel Development Signal Transduction Determination Of Left/right Symmetry Gastrulation Heart Development Anterior/posterior Pattern Specification Nodal Signaling Pathway
Pathways			Signaling by NODAL Regulation of signaling by NODAL
Drugs
Diseases			Conotruncal heart malformations, including: Double-outlet right ventricle; Persistent truncus arteriosus; Conotruncal anomaly face syndrome Heterotaxy; Situs ambiguus
GWAS
Interacting Genes		51 interacting genes: ATF7IP BHLHE40 C1orf94 CD68 CDA CFTR CLDN19 DAZAP2 DCUN1D1 EMP1 EMP3 EPN1 EPN2 FAM168A FOXD4L3 GGA3 GJB2 GLIS2 HEY1 HEYL HGS HIVEP1 MAP3K1 MED25 MTURN NTAQ1 OTUB2 PIP4P1 PITX1 POGZ PROP1 RHBDD1 RPS27A RUNX1 SFT2D1 SNRPB STAM2 SYNGR1 TAX1BP1 TRARG1 UBA52 UBAC1 UBAP2 UBASH3A UBB UBC UBQLN2 UBXN6 UPF1 YOD1 ZFAND2A
Entrez ID		55041	55997
HPRD ID		15144	05548
Ensembl ID		ENSG00000115762	ENSG00000136698
Uniprot IDs		A0A0A0MSE9 A0A0A0MSI4 B4DJB7 Q96CS7	A0A087WWV2 A0A087WX98 P0CG37
PDB IDs		3AJ4 3VIA
Enriched GO Terms of Interacting Partners?		Protein Tag Activity Endosome Membrane ESCRT-0 Complex Positive Regulation Of Macromolecule Metabolic Process Cytoplasm DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Macromolecule Catabolic Process Endocytic Vesicle Membrane Post-translational Protein Modification Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Binding Autophagy Endosome Transport Via Multivesicular Body Sorting Pathway Ubiquitin Binding Clathrin Vesicle Coat ERAD Pathway Early Endosome Membrane Bleb Assembly Multivesicular Body Sorting Pathway Endosome Protein K11-linked Deubiquitination Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
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