TMEM179B and KTN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM179B	KTN1
Description		transmembrane protein 179B	kinectin 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleolus Plasma Membrane Membrane Nuclear Speck Secretory Granule Membrane Azurophil Granule Membrane Ficolin-1-rich Granule Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	Protein Binding	RNA Binding Protein Binding Kinesin Binding Cadherin Binding
	Biological Process		Microtubule-based Movement Protein Transport
Pathways		Neutrophil degranulation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate KTN1 Post-translational protein phosphorylation RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle RND3 GTPase cycle RND2 GTPase cycle
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Brain morphology (MOSTest) ( 32665545) Early spontaneous preterm birth ( 31194736) Lean body mass ( 28552196) Neurofibrillary tangles ( 31497858) Plasma anti-thyroglobulin levels ( 29678681) Subcortical brain region volumes ( 25607358)
Interacting Genes		47 interacting genes: ADIPOQ BTN2A2 C1QL4 C2CD2L C3orf52 CCDC167 CCL3L3 CCL4 CCL4L2 CD68 CLCA4 CLCN7 CLDN1 CLDN6 CTXN3 CYB561 DERL3 ERGIC3 FAM163A FATE1 FCER1G FXYD3 GALNT15 GKN1 GPR151 GUCA2A IGFBP5 KRTAP12-2 KTN1 LRP10 LYG1 MARCHF2 MFSD6 PLN SERP2 SLC1A1 SLC22A1 SLC52A1 SLC61A1 STX8 TM4SF19 TMEM14A TMEM236 TMEM237 TMEM242 TMEM47 TRARG1	31 interacting genes: ABI1 BNIP3 CD3G CD68 CDC42 CLEC4C CLEC7A EEF1D FFAR2 FILNC1 IKBKE KIF5B KIR2DL3 LHFPL5 M6PR MEOX2 PDCD1LG2 PLEKHA5 RAC1 RHOA RHOG RNF10 SGTA SIRPA SLC71A2 STOM SUSD3 SYNE4 SYNPR TMEM179B UBE2I
Entrez ID		374395	3895
HPRD ID		14186	02661
Ensembl ID		ENSG00000185475	ENSG00000126777
Uniprot IDs		G3V185 Q7Z7N9	Q86UP2
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Inorganic Anion Transport	Ficolin-1-rich Granule Membrane Establishment Or Maintenance Of Cell Polarity Secretory Granule Membrane Establishment Of Epithelial Cell Apical/basal Polarity Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Membrane Polarized Epithelial Cell Differentiation Establishment Of Epithelial Cell Polarity Wnt Signaling Pathway, Planar Cell Polarity Pathway Glutamatergic Synapse G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Immune System Process Membrane Invagination Actin Filament Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Stress Fiber Assembly Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Non-canonical Wnt Signaling Pathway Azurophil Granule Membrane Thioesterase Binding Regulation Of Interleukin-23 Production Regulation Of Synapse Organization Positive Regulation Of Actin Filament Bundle Assembly Immune Response Tertiary Granule Membrane Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Antifungal Innate Immune Response G Protein Activity Regulation Of Canonical NF-kappaB Signal Transduction Plasma Membrane Cellular Response To Type II Interferon Positive Regulation Of Immune System Process Regulation Of Immune System Process Response To External Biotic Stimulus Positive Regulation Of Protein Localization To Membrane Regulation Of Respiratory Burst Regulation Of Modification Of Synaptic Structure Establishment Of Cell Polarity GTP-dependent Protein Binding Regulation Of Stress Fiber Assembly Regulation Of Cell Maturation Postsynapse Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Type II Interferon Regulation Of Chemokine Production Rac Protein Signal Transduction
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