CLEC2D and B3GALT5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLEC2D	B3GALT5
Description		C-type lectin domain family 2 member D	beta-1,3-galactosyltransferase 5
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Carbohydrate Binding	Protein Binding N-acetyl-beta-D-glucosaminide Beta-(1,3)-galactosyltransferase Activity Transferase Activity Glycosyltransferase Activity Hexosyltransferase Activity
	Biological Process	Cell Surface Receptor Signaling Pathway	Protein Glycosylation Protein O-linked Glycosylation Lipid Metabolic Process Oligosaccharide Biosynthetic Process Response To Bacterium Carbohydrate Derivative Biosynthetic Process
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Lewis blood group biosynthesis
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) HDL cholesterol levels x short total sleep time interaction (1df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Multiple sclerosis ( 31604244)	Alcohol dependence ( 26365420) Corneal astigmatism ( 29422769) Metabolite levels ( 23823483) Obsessive-compulsive symptoms ( 26859814) Suicide risk ( 21041247)
Interacting Genes		33 interacting genes: ADIPOQ ATP6V0C B3GALT5 BRICD5 CD68 CLDN19 CLDN2 CLEC2A CLRN2 CXCL9 DEFB121 ENTPD8 ERMP1 FAM3C FNDC9 GPR42 IL1RL1 KLRB1 KLRC1 LEPROTL1 NKG7 PLLP PLN PLP1 RPRM SEC22A SHMT2 SYT15 SYT15B TM4SF18 TMEM190 TMEM80 TSPAN4	3 interacting genes: CLEC2D DEFB103A DEFB103B
Entrez ID		29121	10317
HPRD ID		16134	06818
Ensembl ID		ENSG00000069493	ENSG00000183778
Uniprot IDs		Q9UHP7 W8JXM2	A0A0A0MS93 Q9Y2C3
PDB IDs		4QKG 4QKH 4QKI 4QKJ 4WCO 5MGT
Enriched GO Terms of Interacting Partners?		Membrane Paracellular Transport Paracellular Tight Junction Channel Activity Defense Response Structural Constituent Of Myelin Sheath	CCR6 Chemokine Receptor Binding Preribosome, Small Subunit Precursor Chemoattractant Activity Killing By Host Of Symbiont Cells Biological Process Involved In Interaction With Symbiont Positive Chemotaxis Defense Response To Gram-negative Bacterium ABC-type Sterol Transporter Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Golgi Lumen Killing Of Cells Of Another Organism Defense Response To Gram-positive Bacterium Glycoprotein Transport Cellular Response To High Density Lipoprotein Particle Stimulus Antimicrobial Humoral Response Floppase Activity Cell Killing RRNA Processing Phosphatidylcholine Floppase Activity Cell Chemotaxis Toxin Transmembrane Transporter Activity Granular Component RRNA Metabolic Process Humoral Immune Response Negative Regulation Of Cholesterol Storage Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Xenobiotic Export From Cell Low-density Lipoprotein Particle Remodeling Phospholipid Homeostasis Phospholipid Efflux Amyloid Precursor Protein Catabolic Process Reverse Cholesterol Transport External Side Of Plasma Membrane Negative Regulation Of Macrophage Derived Foam Cell Differentiation Response To Other Organism Negative Regulation Of GTPase Activity Locomotion Defense Response To Bacterium Chemotaxis Host-mediated Activation Of Viral Transcription Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Amyloid-beta Formation Negative Regulation Of Lipid Storage Intracellular Cholesterol Transport High-density Lipoprotein Particle Remodeling Response To External Biotic Stimulus Response To Bacterium Intracellular Sterol Transport Cholesterol Transfer Activity Amyloid Precursor Protein Metabolic Process
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