EIF1AX

Description		eukaryotic translation initiation factor 1A X-linked
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GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Multi-eIF Complex Synapse
	Molecular Function	TRNA Binding RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding
	Biological Process	Translation Translational Initiation Ribosome Assembly
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS
Interacting Genes		9 interacting genes: APP EIF2S1 EIF3C EIF5 EIF5B HSPB1 IKBKG IPO13 RFPL3
Entrez ID		1964
HPRD ID		02174
Ensembl ID		ENSG00000173674
Uniprot IDs		P47813
PDB IDs		1D7Q 3ZJY 4KZY 4KZZ 6YBW 6ZMW 6ZP4 7A09 7QP6 7QP7 7SYQ 7SYR 7SYS 7SYV 7SYW 7SYX 7TQL 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL
Enriched GO Terms of Interacting Partners?		Translation Initiation Factor Activity Regulation Of Translation Translational Initiation Post-transcriptional Regulation Of Gene Expression Regulation Of Translational Initiation Regulation Of Protein Metabolic Process Cellular Response To Manganese Ion Response To Manganese Ion Translation Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic 48S Preinitiation Complex Ribosome Assembly Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Gene Expression Protein-containing Complex Assembly Regulation Of Macromolecule Biosynthetic Process Cytoplasm Membraneless Organelle Assembly Protein-containing Complex Organization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Cellular Component Assembly Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Translation Initiation Ternary Complex RNA Binding Negative Regulation Of Protein Kinase C Signaling Positive Regulation Of Interleukin-1 Production Regulation Of Macromolecule Metabolic Process Ribosome Binding Axo-dendritic Transport Regulation Of Apoptotic Signaling Pathway Synapse Response To Heat Acetylcholine Receptor Activator Activity Regulation Of Response To Endoplasmic Reticulum Stress Lipoprotein Particle Positive Regulation Of Protein Import PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Metabolic Process
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