GABBR2 and SPIN1

		GABBR2	SPIN1
Description		gamma-aminobutyric acid type B receptor subunit 2	spindlin 1
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane G Protein-coupled Receptor Heterodimeric Complex Neuron Projection Synapse Postsynaptic Membrane GABA Receptor Complex G Protein-coupled GABA Receptor Complex	Chromatin Nucleus Nucleoplasm Nucleolus Spindle Cytosol Nuclear Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled GABA Receptor Activity Protein Binding GABA Receptor Activity Protein Heterodimerization Activity	Protein Binding Histone H3K4me3 Reader Activity Histone Reader Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Synaptic Transmission, GABAergic Neuron-glial Cell Signaling	Chromatin Organization Regulation Of DNA-templated Transcription Gamete Generation RRNA Transcription Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of DNA-templated Transcription Meiotic Cell Cycle Protein Localization To Chromatin Transposable Element Silencing By PiRNA-mediated DNA Methylation
Pathways		Activation of G protein gated Potassium channels G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) GABA B receptor activation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs		Baclofen gamma-Aminobutyric acid SGS-742 Arbaclofen Arbaclofen Placarbil Sodium oxybate
Diseases
GWAS		Autism spectrum disorder ( 34069769) Gynecologic disease (multivariate analysis) ( 31488892) High chromosomal aberration frequency (chromatid type) ( 31586183) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Response to simvastatin treatment (PCSK9 protein level change) ( 25089948) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Schizophrenia ( 30285260) Systolic blood pressure change trajectory ( 27980656) tricyclic pyrone compound response (IC50) ( 33610756)	Height ( 18391951 20881960 31562340) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		10 interacting genes: ATF4 ATF5 DRD2 GABBR1 GLP1R HTR1A KCTD12 NSF SH3GL3 TAMALIN	5 interacting genes: HMGB1 HSPB1 PRMT6 PTN RPL5
Entrez ID		9568	10927
HPRD ID		09552	18096
Ensembl ID		ENSG00000136928	ENSG00000106723
Uniprot IDs		H9NIL8 O75899	Q9Y657
PDB IDs		4F11 4F12 4MQE 4MQF 4MR7 4MR8 4MR9 4MRM 4MS1 4MS3 4MS4 4PAS 6M8R 6OCP 6UO8 6UO9 6UOA 6VJM 6W2X 6WIV 7C7Q 7C7S 7CA3 7CA5 7CUM 7EB2	2NS2 4H75 4MZF 4MZG 4MZH 5JSG 5JSJ 5Y5W 6I8B 6I8L 6I8Y 6QPL 7BQZ 7BU9 7CNA 7E9M 7EA1 7OCB 8GTX
Enriched GO Terms of Interacting Partners?		Gamma-aminobutyric Acid Signaling Pathway Negative Regulation Of Dopamine Secretion Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Postsynaptic Membrane Regulation Of Growth Hormone Secretion Positive Regulation Of Growth Hormone Secretion Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Catecholamine Secretion GABA-ergic Synapse Regulation Of Transport Circadian Rhythm RNA Polymerase II Transcription Regulator Complex Presynaptic Membrane Regulation Of Receptor-mediated Endocytosis Regulation Of Dopamine Secretion G Protein-coupled Receptor Activity Ionotropic Glutamate Receptor Binding Negative Regulation Of Transport Regulation Of Catecholamine Secretion Negative Regulation Of Synaptic Transmission Dendritic Shaft Response To Nicotine Regulation Of Signaling Negative Regulation Of Blood Pressure Synapse Glucagon-like Peptide 1 Receptor Activity Regulation Of Hormone Levels Circadian Regulation Of Gene Expression Cell-cell Signaling ATF1-ATF4 Transcription Factor Complex Rhythmic Process CHOP-ATF4 Complex Regulation Of Hormone Secretion Regulation Of Blood Circulation G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Regulation Of Vesicle-mediated Transport Regulation Of Secretion Glutamatergic Synapse Regulation Of Secretion By Cell G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential G Protein-coupled GABA Receptor Activity G Protein-coupled Receptor Dimeric Complex G Protein-coupled GABA Receptor Complex G Protein-coupled Receptor Heterodimeric Complex G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Presynaptic Membrane Potential Negative Regulation Of Gamma-aminobutyric Acid Secretion Sphinganine Biosynthetic Process Regulation Of Fat Cell Apoptotic Process Sphinganine Metabolic Process	Positive Regulation Of Chemotaxis Regulation Of Endothelial Cell Migration Regulation Of Chemotaxis Base-excision Repair Positive Regulation Of Interleukin-1 Production Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Catalytic Activity Calcium-dependent Protein Kinase Regulator Activity Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Restriction Endodeoxyribonuclease Activity Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Cell Migration Regulation Of Multicellular Organismal Development Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Cell Motility Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Locomotion Negative Regulation Of Apoptotic Cell Clearance Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Hemopoiesis Regulation Of Interleukin-1 Beta Production Negative Regulation Of Protein Kinase C Signaling Dendrite Regeneration Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Signal Transduction By P53 Class Mediator G Protein-coupled GABA Receptor Complex G Protein-coupled GABA Receptor Activity G Protein-coupled Receptor Heterodimeric Complex Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Leukocyte Chemotaxis C-X-C Chemokine Binding Alphav-beta3 Integrin-HMGB1 Complex T-helper 1 Cell Activation Positive Regulation Of Mismatch Repair Protein Kinase C Inhibitor Activity Ossification Involved In Bone Remodeling Negative Regulation Of Proteolysis GABA Receptor Complex Histone Arginine N-methyltransferase Activity Integrin Binding Positive Regulation Of Leukocyte Migration Negative Regulation Of Catalytic Activity Regulation Of Mismatch Repair Plasmacytoid Dendritic Cell Activation
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