GABBR2 and SPTLC1

		GABBR2	SPTLC1
Description		gamma-aminobutyric acid type B receptor subunit 2	serine palmitoyltransferase long chain base subunit 1
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane G Protein-coupled Receptor Heterodimeric Complex Neuron Projection Synapse Postsynaptic Membrane GABA Receptor Complex G Protein-coupled GABA Receptor Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Serine Palmitoyltransferase Complex
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled GABA Receptor Activity Protein Binding GABA Receptor Activity Protein Heterodimerization Activity	Serine C-palmitoyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Pyridoxal Phosphate Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Synaptic Transmission, GABAergic Neuron-glial Cell Signaling	Lipid Metabolic Process Sphingolipid Metabolic Process Sphingomyelin Biosynthetic Process Sphingolipid Biosynthetic Process Amide Biosynthetic Process Sphinganine Biosynthetic Process Sphingosine Biosynthetic Process Ceramide Biosynthetic Process Positive Regulation Of Lipophagy Regulation Of Fat Cell Apoptotic Process
Pathways		Activation of G protein gated Potassium channels G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) GABA B receptor activation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Sphingolipid de novo biosynthesis
Drugs		Baclofen gamma-Aminobutyric acid SGS-742 Arbaclofen Arbaclofen Placarbil Sodium oxybate	Pyridoxal phosphate Serine
Diseases
GWAS		Autism spectrum disorder ( 34069769) Gynecologic disease (multivariate analysis) ( 31488892) High chromosomal aberration frequency (chromatid type) ( 31586183) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Response to simvastatin treatment (PCSK9 protein level change) ( 25089948) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Schizophrenia ( 30285260) Systolic blood pressure change trajectory ( 27980656) tricyclic pyrone compound response (IC50) ( 33610756)	Bipolar disorder and schizophrenia ( 22688191) Left inferior lateral ventricle volume (Cerebrospinal fluid biomarker status interaction) ( 25140149) Serum immune biomarker levels ( 32066700)
Interacting Genes		10 interacting genes: ATF4 ATF5 DRD2 GABBR1 GLP1R HTR1A KCTD12 NSF SH3GL3 TAMALIN	3 interacting genes: ABCA1 GTF2IRD1 SPTLC2
Entrez ID		9568	10558
HPRD ID		09552	05754
Ensembl ID		ENSG00000136928	ENSG00000090054
Uniprot IDs		H9NIL8 O75899	O15269 Q6NUL7
PDB IDs		4F11 4F12 4MQE 4MQF 4MR7 4MR8 4MR9 4MRM 4MS1 4MS3 4MS4 4PAS 6M8R 6OCP 6UO8 6UO9 6UOA 6VJM 6W2X 6WIV 7C7Q 7C7S 7CA3 7CA5 7CUM 7EB2	6M4N 6M4O 7CQI 7CQK 7K0I 7K0J 7K0K 7K0L 7K0M 7K0N 7K0O 7K0P 7K0Q 7YIU 7YIY 7YJ1 7YJ2
Enriched GO Terms of Interacting Partners?		Gamma-aminobutyric Acid Signaling Pathway Negative Regulation Of Dopamine Secretion Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Postsynaptic Membrane Regulation Of Growth Hormone Secretion Positive Regulation Of Growth Hormone Secretion Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Catecholamine Secretion GABA-ergic Synapse Regulation Of Transport Circadian Rhythm RNA Polymerase II Transcription Regulator Complex Presynaptic Membrane Regulation Of Receptor-mediated Endocytosis Regulation Of Dopamine Secretion G Protein-coupled Receptor Activity Ionotropic Glutamate Receptor Binding Negative Regulation Of Transport Regulation Of Catecholamine Secretion Negative Regulation Of Synaptic Transmission Dendritic Shaft Response To Nicotine Regulation Of Signaling Negative Regulation Of Blood Pressure Synapse Glucagon-like Peptide 1 Receptor Activity Regulation Of Hormone Levels Circadian Regulation Of Gene Expression Cell-cell Signaling ATF1-ATF4 Transcription Factor Complex Rhythmic Process CHOP-ATF4 Complex Regulation Of Hormone Secretion Regulation Of Blood Circulation G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Regulation Of Vesicle-mediated Transport Regulation Of Secretion Glutamatergic Synapse Regulation Of Secretion By Cell G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential G Protein-coupled GABA Receptor Activity G Protein-coupled Receptor Dimeric Complex G Protein-coupled GABA Receptor Complex G Protein-coupled Receptor Heterodimeric Complex G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Presynaptic Membrane Potential Negative Regulation Of Gamma-aminobutyric Acid Secretion Sphinganine Biosynthetic Process Regulation Of Fat Cell Apoptotic Process Sphinganine Metabolic Process	Response To Vitamin B3 Positive Regulation Of High-density Lipoprotein Particle Assembly Apolipoprotein A-I Receptor Activity Sphingolipid Floppase Activity Sphinganine Biosynthetic Process Sphinganine Metabolic Process G Protein-coupled GABA Receptor Complex G Protein-coupled GABA Receptor Activity G Protein-coupled Receptor Heterodimeric Complex Transition Between Slow And Fast Fiber Apolipoprotein A-I-mediated Signaling Pathway Floppase Activity Regulation Of High-density Lipoprotein Particle Assembly Sphingolipid Translocation Apolipoprotein A-I Binding Phosphatidylserine Floppase Activity Positive Regulation Of Lipophagy Serine C-palmitoyltransferase Activity GABA Receptor Complex Neuron-glial Cell Signaling Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Lipoprotein Biosynthetic Process Phosphatidylcholine Floppase Activity GABA Receptor Activity Serine Palmitoyltransferase Complex High-density Lipoprotein Particle Assembly Alcohol Metabolic Process High-density Lipoprotein Particle Binding ATPase-coupled Intramembrane Lipid Transporter Activity Negative Regulation Of Cholesterol Storage Sphingomyelin Biosynthetic Process Negative Regulation Of Adenylate Cyclase Activity Regulation Of Skeletal Muscle Adaptation Phospholipid Efflux Regulation Of Cdc42 Protein Signal Transduction Negative Regulation Of Macrophage Derived Foam Cell Differentiation Sphingosine Biosynthetic Process Sphingoid Biosynthetic Process Phospholipid Homeostasis Phospholipid Transporter Activity Apolipoprotein Binding Reverse Cholesterol Transport Cellular Response To Cholesterol Positive Regulation Of Viral Entry Into Host Cell Negative Regulation Of Defense Response To Virus Sphingosine Metabolic Process Cellular Response To Sterol Intracellular Vesicle Sphingomyelin Metabolic Process Intracellular Cholesterol Transport
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