RP9 and CIRSR

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology)

		RP9	CIRSR
Description		RP9 pre-mRNA splicing factor	corepressor of RBPJ and splicing regulator
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Signal Recognition Particle Receptor Complex	Nucleus Cytoplasm Centrosome Cytoskeleton Nuclear Speck Protein-containing Complex
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Transcription Corepressor Activity Protein Binding Protein Kinase Binding Histone Deacetylase Binding Protein-containing Complex Binding
	Biological Process	RNA Splicing Cognition	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development MRNA Processing RNA Splicing Negative Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases		Retinitis pigmentosa (RP)
GWAS
Interacting Genes		10 interacting genes: AP1M1 APP BYSL C1orf35 CIRSR FGF12 NKAPD1 SDCBP SREK1IP1 U2AF1	17 interacting genes: CCDC33 CEP76 DPPA4 FXR1 HDAC2 HOXA1 MB21D2 NCOR2 NEK6 OGT RBPJ RP9 SAP30 SNW1 SRSF2 TCEA1 U2AF1
Entrez ID		6100	9541
HPRD ID		08457	05568
Ensembl ID		ENSG00000164610	ENSG00000138433
Uniprot IDs		A0A090N8Z0 Q8TA86	Q86X95
PDB IDs			6ZYM 8I0W
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Adult Locomotory Behavior Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Trans-synaptic Signaling Chemical Synaptic Transmission Regulation Of Response To Calcium Ion Trans-Golgi Network Membrane Amylin Binding Positive Regulation Of JNK Cascade Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Synaptic Signaling Regulation Of Receptor Internalization Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Frizzled Binding Astrocyte Activation Involved In Immune Response Regulation Of Nervous System Process Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Synapse Low-density Lipoprotein Particle Mediated Signaling RNA Processing Regulation Of Voltage-gated Sodium Channel Activity Interleukin-5 Receptor Binding Interleukin-5 Receptor Complex Positive Regulation Of Extracellular Exosome Assembly Syndecan Binding MRNA Processing RNA Splicing Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Regulation Of Receptor-mediated Endocytosis Growth Factor Receptor Binding Main Axon Protein Insertion Into Mitochondrial Inner Membrane From Matrix Regulation Of Neuronal Action Potential	Sin3-type Complex Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of RNA Metabolic Process Regulation Of Stem Cell Population Maintenance Transcription Corepressor Activity Regulation Of Behavior Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Retinoic Acid Receptor Binding Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Notch Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Male Mating Behavior Nucleoplasm Regulation Of RNA Metabolic Process Nucleus Histone Deacetylase Complex Protein-containing Complex Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway DNA-binding Transcription Factor Binding Semicircular Canal Formation Positive Regulation Of Ephrin Receptor Signaling Pathway Arterial Endothelial Cell Fate Commitment RNA Splicing Nuclear Speck Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Nuclear Receptor Binding FMN Transmembrane Transporter Activity FAD Transmembrane Transporter Activity FAD Transmembrane Transport Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin Binding Positive Regulation Of Neurogenesis Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Protein De-2-hydroxyisobutyrylase Activity Positive Regulation Of Developmental Process Regulation Of Transcription By RNA Polymerase II Artery Morphogenesis Abducens Nerve Formation Optokinetic Behavior Transcription Repressor Complex
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