SP140

Description		SP140 nuclear body protein
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleolus Cytoplasm Mitochondrion PML Body
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Defense Response
Pathways
Drugs
Diseases
GWAS		Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic lymphocytic leukemia ( 23770605 24292274 18758461 28165464) Crohn's disease ( 21102463 23128233 28067908) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Inflammatory bowel disease ( 28067908) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244 24076602 21833088) Neutrophil percentage of granulocytes ( 27863252) Night sleep phenotypes ( 27126917) Sum eosinophil basophil counts ( 27863252)
Novel Interacting Genes		1 novel interacting genes: EIF4E2
Interacting Genes		2 interacting genes: NFE2L2 SIRT2
Entrez ID		11262
HPRD ID		09780
Ensembl ID		ENSG00000079263
Uniprot IDs		B4DVW8 Q0VGE4 Q13342 Q8IWJ1
PDB IDs		2MD7 2MD8 6G8R 8J70 8J71
Enriched GO Terms of Interacting Partners?		Response To Caloric Restriction Cellular Response To Decreased Oxygen Levels Regulation Of Reactive Oxygen Species Metabolic Process Cellular Response To Oxygen Levels Cellular Response To Hypoxia Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Glutathione Biosynthetic Process Regulation Of Glutathione Biosynthetic Process Positive Regulation Of Proteasomal Protein Catabolic Process Aflatoxin Catabolic Process Histone H4K16 Deacetylase Activity, NAD-dependent Negative Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Caloric Restriction NAD-dependent Protein Depalmitoylase Activity Tubulin Deacetylase Activity NAD-dependent Protein Demyristoylase Activity Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Cellular Response To Oxidative Stress Tubulin Deacetylation Positive Regulation Of Oocyte Maturation Peptidyl-lysine Deacetylation Proteasomal Ubiquitin-independent Protein Catabolic Process Toxin Catabolic Process Negative Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Protein Metabolic Process MRNA Cap Binding Lateral Loop Negative Regulation Of Peptidyl-threonine Phosphorylation Cellular Response To Chemical Stress Response To Hypoxia Histone Deacetylase Activity, NAD-dependent Negative Regulation Of Satellite Cell Differentiation Ubiquitin Protein Ligase Binding Cellular Response To Methionine Response To Decreased Oxygen Levels Regulation Of Removal Of Superoxide Radicals Regulation Of Oligodendrocyte Progenitor Proliferation Response To Methionine Response To Oxygen Levels RDNA Heterochromatin Formation Negative Regulation Of Skeletal Muscle Cell Differentiation NAD-dependent Protein Lysine Deacetylase Activity Aflatoxin Metabolic Process Regulation Of Protein Catabolic Process Response To Oxidative Stress Skeletal Muscle Satellite Cell Differentiation
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