CD34 and CREM

Number of citations of the paper that reports this interaction (PMID 10373550)
21

Data Source:
BioGRID (two hybrid)

		CD34	CREM
Gene Name		CD34 molecule	cAMP responsive element modulator
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Basal Plasma Membrane Apical Plasma Membrane Glomerular Endothelium Fenestra Intercellular Bridge Perinuclear Region Of Cytoplasm	Nucleus Transcription Factor Complex Cytoplasm
	Molecular Function	Transcription Factor Binding Carbohydrate Binding Sulfate Binding	Core Promoter Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding CAMP Response Element Binding Protein Binding
	Biological Process	Tissue Homeostasis Endothelial Cell Proliferation Glomerular Filtration Endothelium Development Signal Transduction Regulation Of Blood Pressure Cell Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Single Organismal Cell-cell Adhesion Hemopoiesis Negative Regulation Of Blood Coagulation Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-10 Production Mesangial Cell-matrix Adhesion Paracrine Signaling Positive Regulation Of Odontogenesis Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Cell Motility Regulation Of Immune Response Leukocyte Migration Transdifferentiation Vascular Wound Healing Hematopoietic Stem Cell Proliferation Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Granulocyte Colony-stimulating Factor Production Extracellular Vesicular Exosome Assembly Glomerular Endothelium Development Stem Cell Proliferation Metanephric Glomerular Mesangial Cell Differentiation Negative Regulation Of Cellular Response To Heat Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Interleukin-2 Secretion Positive Regulation Of Glial Cell Line-derived Neurotrophic Factor Secretion Negative Regulation Of Neuron Death Positive Regulation Of Vasculogenesis	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Glycosphingolipid Metabolic Process Signal Transduction Multicellular Organismal Development Spermatogenesis Cell Differentiation Circadian Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To CAMP
Pathways
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23326517) Heart rate ( 23583979) Resting heart rate ( 20639392)	Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		5 interactors: ATF5 CHST4 CREM CRKL PRKCD	29 interactors: ATF1 ATXN1 CAMK2D CAMK2G CASP8AP2 CD34 CDC34 CDK1 CREB1 CREB3L1 CREBBP CSNK1A1 CSNK2A1 CSNK2A2 EMP3 FHL5 GSK3A GSK3B HDAC1 KCNIP3 MAPK3 PIAS3 PRKACA PRKCA SP100 SPI1 TAF4 TBP UBE2I
Entrez ID		947	1390
HPRD ID		00790	00444
Ensembl ID		ENSG00000174059	ENSG00000095794
Uniprot IDs		B4DG27 P28906 Q5JTA5	Q03060
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Positive Regulation Of Phospholipid Catabolic Process Circadian Rhythm Interleukin-10 Production Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Filopodium Assembly Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Interleukin-12 Production Positive Regulation Of Ceramide Biosynthetic Process Olfactory Bulb Interneuron Development Regulation Of Ceramide Biosynthetic Process Rhythmic Process Positive Regulation Of Phospholipid Transport Negative Regulation Of Platelet Aggregation Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Metabolic Process Parathyroid Gland Development Protein Sulfation Positive Regulation Of Cellular Biosynthetic Process Olfactory Bulb Interneuron Differentiation Leukocyte Tethering Or Rolling Negative Regulation Of Astrocyte Differentiation Regulation Of Superoxide Anion Generation Regulation Of Platelet Aggregation Negative Regulation Of Platelet Activation Positive Regulation Of Protein Dephosphorylation Sulfation Neutrophil Activation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress N-acetylglucosamine Metabolic Process Positive Regulation Of Lipid Catabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Astrocyte Differentiation Negative Regulation Of Cellular Metabolic Process Response To Growth Factor Cellular Extravasation Regulation Of Platelet Activation Cellular Senescence Regulation Of MAPK Cascade Immune System Process Negative Regulation Of Glial Cell Differentiation Forebrain Neuron Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Olfactory Bulb Development B Cell Proliferation	Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Response To Heat Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Cardiac Muscle Hypertrophy Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transcription, DNA-templated Response To Growth Factor Cell Death Death Cellular Protein Modification Process Regulation Of Metabolic Process Cell Cycle RNA Biosynthetic Process Regulation Of Cellular Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Gene Expression Peptidyl-serine Phosphorylation Hypermethylation Of CpG Island Peptidyl-amino Acid Modification Nucleobase-containing Compound Metabolic Process Apoptotic Process Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Cell Surface Receptor Signaling Pathway Programmed Cell Death Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Phosphorylation Macromolecule Biosynthetic Process Cellular Response To Heat Heterocycle Metabolic Process
Tagcloud ?		agvhd alive allogeneic allografting allotransplantation anc ards august cgvhd donors evaluable february follows grades gvhd hematological leukaphereses mismatched mononucleated pbpc reach recipient scored september siblings sickle transplant unrelated unsupported	27mer abp activin artefact artefactual basally bluescript bouin crna cystatin digoxigenin distinguishable inhibin ix leptotene promotor propria protamine pyronin rbs riboprobes seminiferous sgp spermatocytes sulphated t7 trichloroacetic tubules viii
Tagcloud (Difference) ?		agvhd alive allogeneic allografting allotransplantation anc ards august cgvhd donors evaluable february follows grades gvhd hematological leukaphereses mismatched mononucleated pbpc reach recipient scored september siblings sickle transplant unrelated unsupported	27mer abp activin artefact artefactual basally bluescript bouin crna cystatin digoxigenin distinguishable inhibin ix leptotene promotor propria protamine pyronin rbs riboprobes seminiferous sgp spermatocytes sulphated t7 trichloroacetic tubules viii
Tagcloud (Intersection) ?