C4orf17 and SH3GL3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		C4orf17	SH3GL3
Gene Name		chromosome 4 open reading frame 17	SH3-domain GRB2-like 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Early Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function		Protein Binding Lipid Binding Identical Protein Binding
	Biological Process		Endocytosis Signal Transduction Central Nervous System Development
Pathways
Drugs
Diseases
GWAS		Eating disorders ( 23568457) Metabolite levels (MHPG) ( 23319000)	Height ( 18391950 18391951 20397748)
Protein-Protein Interactions		7 interactors: CHD3 COPS6 KDM1A PRMT1 SH3GL3 SUV39H1 TUBA4A	44 interactors: ADRB1 AES ARHGDIA ARHGEF6 ATXN2 C11orf68 C4orf17 CALCOCO1 CBLC CD101 CRIP1 DNM1 DPPA4 DPYSL4 EGFL6 EMD FAM173A FASLG GABBR2 HTT LRRK2 NDUFB9 PDCD6IP PIAS4 PTPRO QTRT1 RBM48 RER1 RPL35A SEPT8 SH3D19 SH3GL1 SH3GL2 SH3KBP1 SHC3 SNRPN SNX24 SYNJ1 TERF1 TNNT1 TOE1 VIM WASL WDR33
Entrez ID		84103	6457
HPRD ID		12825	04528
Ensembl ID		ENSG00000138813	ENSG00000140600
Uniprot IDs		Q53FE4	Q99963
PDB IDs			2EW3 2Z0V
Enriched GO Terms of Interacting Partners?		Regulation Of Megakaryocyte Differentiation Chromatin Modification Chromatin Organization Regulation Of Hematopoietic Progenitor Cell Differentiation Chromosome Organization Histone Modification Regulation Of Primitive Erythrocyte Differentiation Histone Methylation Organelle Organization Protein Methylation Regulation Of Myeloid Cell Differentiation Negative Regulation Of Megakaryocyte Differentiation Histone H3-K9 Dimethylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Histone H3-K4 Demethylation Cullin Deneddylation Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Megakaryocyte Differentiation Cellular Protein Metabolic Process Histone H3-K9 Trimethylation Protein Deneddylation Peptidyl-lysine Dimethylation Positive Regulation Of Hormone Biosynthetic Process Peptidyl-arginine N-methylation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Histone H3-K9 Methylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Histone H4-R3 Methylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Chromatin Silencing At RDNA Granulocyte Differentiation Histone Arginine Methylation Cell Cycle Peptidyl-arginine Methylation Negative Regulation Of Histone Methylation Methylation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Circadian Rhythm Blood Coagulation Hemostasis Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Histone H3-K9 Methylation Microtubule Cytoskeleton Organization Regulation Of Histone H3-K4 Methylation Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Hormone Biosynthetic Process	Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Signaling Regulation Of ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell-cell Signaling Signal Transduction Vesicle-mediated Transport Cell Communication Movement Of Cell Or Subcellular Component Regulation Of Vesicle-mediated Transport Response To Stimulus Cellular Response To Stimulus Cell Death Death Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Membrane Organization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Negative Regulation Of ERBB Signaling Pathway Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Developmental Process System Development Neuron Development Apoptotic Process Cellular Process Generation Of Neurons Actin Filament-based Movement Multicellular Organismal Development Nervous System Development Programmed Cell Death Regulation Of Signaling Neurogenesis Regulation Of Endocytosis Regulation Of Signal Transduction Negative Regulation Of Neuron Differentiation Neuron Projection Development Establishment Of Vesicle Localization Synaptic Transmission Positive Regulation Of Apoptotic Process Cell Projection Morphogenesis Neuron Differentiation Vesicle Localization Response To Growth Factor Axon Guidance Neurotrophin TRK Receptor Signaling Pathway Cell Part Morphogenesis
Tagcloud ?			85k aorta cbl cin85 circulation circulatory cooperation da diameters dorsal endocytosis exerted impairing interacting lumen lumens morpholino morpholinos partner phosphatidylinositol shrinkage shrunken specification stereotyped studying unaffected vasculature zebrafish
Tagcloud (Difference) ?			85k aorta cbl cin85 circulation circulatory cooperation da diameters dorsal endocytosis exerted impairing interacting lumen lumens morpholino morpholinos partner phosphatidylinositol shrinkage shrunken specification stereotyped studying unaffected vasculature zebrafish
Tagcloud (Intersection) ?