KCNK4 and ORMDL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KCNK4	ORMDL1
Description		potassium two pore domain channel subfamily K member 4	ORMDL sphingolipid biosynthesis regulator 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Axon Node Of Ranvier Monoatomic Ion Channel Complex Potassium Channel Complex Cell Projection	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Serine Palmitoyltransferase Complex
	Molecular Function	Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Potassium Ion Leak Channel Activity Identical Protein Binding Metal Ion Binding Temperature-gated Cation Channel Activity Mechanosensitive Potassium Channel Activity	Protein Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Memory Response To Mechanical Stimulus Neuronal Action Potential Sensory Perception Of Pain Monoatomic Ion Transmembrane Transport Sensory Perception Of Temperature Stimulus Detection Of Mechanical Stimulus Involved In Sensory Perception Of Touch Cellular Response To Mechanical Stimulus Cellular Response To Fatty Acid Cellular Response To Acidic PH Cellular Response To Alkaline PH Cellular Response To Temperature Stimulus Potassium Ion Transmembrane Transport Cellular Response To Arachidonate Response To Ultrasound	Sphingolipid Metabolic Process Ceramide Metabolic Process Sphingomyelin Biosynthetic Process Sphingolipid Biosynthetic Process Myelination Motor Behavior Regulation Of Sphingolipid Biosynthetic Process Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Regulation Of Ceramide Biosynthetic Process
Pathways		TWIK related potassium channel (TREK) Phase 4 - resting membrane potential	Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Sarcoidosis ( 22837380) Vitiligo ( 27723757)	Bilirubin levels ( 20639394) Ferritin levels ( 25162662)
Interacting Genes		3 interacting genes: DIDO1 ORMDL1 RPL14	42 interacting genes: APP AQP6 ARL13B ASGR2 BIK CD79A COQ9 CPLX4 CREB3 CREB3L1 EBAG9 EBP EHHADH ERGIC3 FAM209A GPR152 HSD17B11 KCNK4 LMNA LNX1 MTIF3 PCNX2 PGRMC2 REEP4 SAR1A SCN3B SLC10A1 SLC10A6 SLC18A1 SLC30A8 SLC35H1 SLC71A2 STOM TIMMDC1 TLCD4 TMEM143 TMEM14B TMEM35A TMEM52B VMA21 ZDHHC15 ZFYVE27
Entrez ID		50801	94101
HPRD ID		12037	15092
Ensembl ID		ENSG00000182450	ENSG00000128699
Uniprot IDs		Q2YDA1 Q9NYG8	Q9P0S3
PDB IDs		3UM7 4I9W 4RUE 4RUF 4WFE 4WFF 4WFG 4WFH 7LJ4 7LJ5 7LJA 7LJB
Enriched GO Terms of Interacting Partners?		Activation Of Protein Kinase B Activity Ventricular Cardiac Muscle Cell Differentiation ErbB-3 Class Receptor Binding Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Protein Autophosphorylation ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB2-ERBB4 Signaling Pathway Endocardial Cell Differentiation ERBB4 Signaling Pathway Nickel Cation Binding ERBB4-ERBB4 Signaling Pathway Intracellular Sphingolipid Homeostasis Serine Palmitoyltransferase Complex Negative Regulation Of Ceramide Biosynthetic Process Negative Regulation Of Sphingolipid Biosynthetic Process Cardiac Muscle Cell Myoblast Differentiation Sphingomyelin Biosynthetic Process Ventricular Trabecula Myocardium Morphogenesis Cardioblast Differentiation Regulation Of Protein Autophosphorylation Regulation Of Ceramide Biosynthetic Process Regulation Of Sphingolipid Biosynthetic Process Protein Tyrosine Kinase Activator Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Large Ribosomal Subunit Sphingomyelin Metabolic Process Regulation Of Membrane Lipid Metabolic Process Heart Trabecula Morphogenesis	Membrane Endoplasmic Reticulum Protein Binding Bile Acid:sodium Symporter Activity Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Membrane
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?