KCNK4

Description		potassium two pore domain channel subfamily K member 4
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GO Annotations	Cellular Component	Plasma Membrane Membrane Axon Node Of Ranvier Monoatomic Ion Channel Complex Potassium Channel Complex Cell Projection
	Molecular Function	Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Potassium Ion Leak Channel Activity Identical Protein Binding Metal Ion Binding Temperature-gated Cation Channel Activity Mechanosensitive Potassium Channel Activity
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Memory Response To Mechanical Stimulus Neuronal Action Potential Sensory Perception Of Pain Monoatomic Ion Transmembrane Transport Sensory Perception Of Temperature Stimulus Detection Of Mechanical Stimulus Involved In Sensory Perception Of Touch Cellular Response To Mechanical Stimulus Cellular Response To Fatty Acid Cellular Response To Acidic PH Cellular Response To Alkaline PH Cellular Response To Temperature Stimulus Potassium Ion Transmembrane Transport Cellular Response To Arachidonate Response To Ultrasound
Pathways		TWIK related potassium channel (TREK) Phase 4 - resting membrane potential
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Sarcoidosis ( 22837380) Vitiligo ( 27723757)
Novel Interacting Genes		1 novel interacting genes: NRG1
Interacting Genes		3 interacting genes: DIDO1 ORMDL1 RPL14
Entrez ID		50801
HPRD ID		12037
Ensembl ID		ENSG00000182450
Uniprot IDs		Q2YDA1 Q9NYG8
PDB IDs		3UM7 4I9W 4RUE 4RUF 4WFE 4WFF 4WFG 4WFH 7LJ4 7LJ5 7LJA 7LJB
Enriched GO Terms of Interacting Partners?		Activation Of Protein Kinase B Activity Ventricular Cardiac Muscle Cell Differentiation ErbB-3 Class Receptor Binding Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Protein Autophosphorylation ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB2-ERBB4 Signaling Pathway Endocardial Cell Differentiation ERBB4 Signaling Pathway Nickel Cation Binding ERBB4-ERBB4 Signaling Pathway Intracellular Sphingolipid Homeostasis Serine Palmitoyltransferase Complex Negative Regulation Of Ceramide Biosynthetic Process Negative Regulation Of Sphingolipid Biosynthetic Process Cardiac Muscle Cell Myoblast Differentiation Sphingomyelin Biosynthetic Process Ventricular Trabecula Myocardium Morphogenesis Cardioblast Differentiation Regulation Of Protein Autophosphorylation Regulation Of Ceramide Biosynthetic Process Regulation Of Sphingolipid Biosynthetic Process Protein Tyrosine Kinase Activator Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Large Ribosomal Subunit Sphingomyelin Metabolic Process Regulation Of Membrane Lipid Metabolic Process Heart Trabecula Morphogenesis
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