CNOT4 and KDM5C

Number of citations of the paper that reports this interaction (PubMedID 19346402)
48

Data Source:
BioGRID (enzymatic study)

		CNOT4	KDM5C
Description		CCR4-NOT transcription complex subunit 4	lysine demethylase 5C
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol CCR4-NOT Complex	Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	Nucleic Acid Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	DNA Binding Protein Binding Zinc Ion Binding Oxidoreductase Activity Histone Demethylase Activity Histone H3K4 Demethylase Activity Histone H3K4me/H3K4me2/H3K4me3 Demethylase Activity Metal Ion Binding Dioxygenase Activity
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Megakaryocyte Differentiation Protein Autoubiquitination	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Rhythmic Process
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors	HDMs demethylate histones
Drugs
Diseases			Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Appendicular lean mass ( 33097823) Clostridioides difficle infection ( 33841421) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Meat-related diet ( 32066663) Numerical cognitive ability ( 31620175)	Monocyte percentage of white cells ( 32888494)
Interacting Genes		18 interacting genes: BCAS2 CNOT1 CNOT3 CNOT6 CNOT8 EP300 IL36RN KDM5C RBM15 UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2W	5 interacting genes: CALM1 CNOT4 H3C15 SUMO2 TRIM11
Entrez ID		4850	8242
HPRD ID		05369	02442
Ensembl ID		ENSG00000080802	ENSG00000126012
Uniprot IDs		O95628	A0A6M4C8G8 A0A8I5KTT1 A0A8I5KYW1 P41229
PDB IDs		1E4U 1UR6	2JRZ 5FWJ
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Catabolic Process Protein K11-linked Ubiquitination CCR4-NOT Complex Protein Monoubiquitination Nuclear-transcribed MRNA Poly(A) Tail Shortening Protein Ubiquitination Protein Modification By Small Protein Conjugation CCR4-NOT Core Complex Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Modification-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Proteolysis Involved In Protein Catabolic Process Poly(A)-specific Ribonuclease Activity Negative Regulation Of Biosynthetic Process TORC1 Signaling Nucleus Nucleic Acid Metabolic Process Protein K63-linked Ubiquitination Protein Modification Process TOR Signaling Transferase Activity Regulation Of TORC1 Signaling ATP Binding Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Proteolysis Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Regulation Of TOR Signaling Nucleotide Binding Nucleobase-containing Compound Catabolic Process Regulatory NcRNA-mediated Gene Silencing Protein Catabolic Process Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process RNA Catabolic Process Negative Regulation Of TORC1 Signaling Protein Autoubiquitination Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Metabolic Process	Presynaptic Cytosol Protein Autoubiquitination Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Protein Modification By Small Protein Conjugation Negative Regulation Of AIM2 Inflammasome Complex Assembly Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Autophagosome Membrane Docking Post-translational Protein Modification Ubiquitin-protein Transferase Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Voltage-gated Calcium Channel Activity Titin Binding Detection Of Calcium Ion Calcium Channel Inhibitor Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Ubiquitin Protein Ligase Activity CCR4-NOT Complex Protein Tag Activity Positive Regulation Of Viral Entry Into Host Cell Regulation Of Cell Communication By Electrical Coupling Negative Regulation Of Viral Transcription
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