CNOT4

Description		CCR4-NOT transcription complex subunit 4
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol CCR4-NOT Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Megakaryocyte Differentiation Protein Autoubiquitination
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors
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Diseases
GWAS		Appendicular lean mass ( 33097823) Clostridioides difficle infection ( 33841421) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Meat-related diet ( 32066663) Numerical cognitive ability ( 31620175)
Interacting Genes		18 interacting genes: BCAS2 CNOT1 CNOT3 CNOT6 CNOT8 EP300 IL36RN KDM5C RBM15 UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2W
Entrez ID		4850
HPRD ID		05369
Ensembl ID		ENSG00000080802
Uniprot IDs		O95628
PDB IDs		1E4U 1UR6
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Catabolic Process Protein K11-linked Ubiquitination CCR4-NOT Complex Protein Monoubiquitination Nuclear-transcribed MRNA Poly(A) Tail Shortening Protein Ubiquitination Protein Modification By Small Protein Conjugation CCR4-NOT Core Complex Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Modification-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Proteolysis Involved In Protein Catabolic Process Poly(A)-specific Ribonuclease Activity Negative Regulation Of Biosynthetic Process TORC1 Signaling Nucleus Nucleic Acid Metabolic Process Protein K63-linked Ubiquitination Protein Modification Process TOR Signaling Transferase Activity Regulation Of TORC1 Signaling ATP Binding Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Proteolysis Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Regulation Of TOR Signaling Nucleotide Binding Nucleobase-containing Compound Catabolic Process Regulatory NcRNA-mediated Gene Silencing Protein Catabolic Process Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process RNA Catabolic Process Negative Regulation Of TORC1 Signaling Protein Autoubiquitination Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Metabolic Process
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