CNOT4

Gene Name		CCR4-NOT transcription complex, subunit 4
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Gene Ontology Annotations	Cellular Component	Nucleus Cytosol CCR4-NOT Complex
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Gene Expression Protein Autoubiquitination
Pathways		Deadenylation of mRNA Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS
Protein-protein Interactions		14 interactors: CNOT1 CNOT8 EP300 KDM5C UBC UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2W
Entrez ID		4850
HPRD ID		05369
Ensembl ID		ENSG00000080802
Uniprot IDs		O95628
PDB IDs		1E4U 1UR6
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Macromolecule Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription In Response To Stress Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Protein Modification Process Protein K63-linked Ubiquitination Toll-like Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxygen Levels Proteasomal Protein Catabolic Process Catabolic Process Protein Monoubiquitination Response To Hypoxia Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Cellular Protein Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Gene Expression Regulation Of Innate Immune Response Cellular Response To Stress Proteolysis Positive Regulation Of Protein Ubiquitination Negative Regulation Of Transcription, DNA-templated Histone Ubiquitination Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Metabolic Process Histone Modification Cellular Response To Organic Substance Innate Immune Response
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