GTF3C3 and DEDD2

Number of citations of the paper that reports this interaction (PubMedID 11965497)
0

Data Source:
BioGRID (pull down)
HPRD (in vivo, two hybrid, in vitro)

		GTF3C3	DEDD2
Description		general transcription factor IIIC subunit 3	death effector domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Transcription Factor TFIIIC Complex Fibrillar Center Nucleus Nucleoplasm Nuclear Membrane	Nucleus Nucleoplasm Nucleolus
	Molecular Function	RNA Polymerase III General Transcription Initiation Factor Activity DNA Binding Protein Binding	DNA Binding Protein Binding Signaling Receptor Complex Adaptor Activity
	Biological Process	Transcription By RNA Polymerase III 5S Class RRNA Transcription By RNA Polymerase III TRNA Transcription By RNA Polymerase III	RNA Processing Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors RRNA Catabolic Process Cellular Homeostasis Apoptotic Nuclear Changes Intracellular Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter
Drugs
Diseases
GWAS			Meat-related diet ( 32066663)
Interacting Genes		11 interacting genes: BRF1 DEDD DEDD2 GTF3C5 HNRNPD NEDD8 PCBD1 PTEN SMARCAD1 TBP UBC	12 interacting genes: ATG16L1 CASP10 CASP8 CDCA7L CDK6 CFLAR DEDD GTF3C3 HNRNPAB NR2E3 RBFOX2 RHOXF2
Entrez ID		9330	162989
HPRD ID		11997	10868
Ensembl ID		ENSG00000119041	ENSG00000160570
Uniprot IDs		Q9Y5Q9	Q8WXF8
PDB IDs		8CLK
Enriched GO Terms of Interacting Partners?		RNA Polymerase III General Transcription Initiation Factor Activity Nucleoplasm Transcription By RNA Polymerase III Nucleus Transcription Initiation At RNA Polymerase III Promoter DNA-templated Transcription Initiation TRNA Transcription Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Tag Activity Regulation Of RNA Metabolic Process Macromolecule Metabolic Process RRNA Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process RNA Metabolic Process Response To Electrical Stimulus Regulation Of Transcription By RNA Polymerase I Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors RRNA Metabolic Process Nucleobase-containing Compound Metabolic Process Hepatocyte Dedifferentiation Cellular Response To Putrescine Negative Regulation Of Synaptic Vesicle Clustering U11/U12 SnRNP Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Transcription Preinitiation Complex Assembly Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Circadian Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity DNA Binding Transcription Factor TFIIIB Complex Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process	Ripoptosome CD95 Death-inducing Signaling Complex Death Effector Domain Binding Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Death-inducing Signaling Complex Cysteine-type Endopeptidase Activity Positive Regulation Of Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway Death Receptor Binding Positive Regulation Of Execution Phase Of Apoptosis Cysteine-type Peptidase Activity Execution Phase Of Apoptosis Regulation Of Necroptotic Process Regulation Of Programmed Necrotic Cell Death Macrophage Differentiation Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Neuron Apoptotic Process Cyclin D2-CDK6 Complex Vacuole-isolation Membrane Contact Site Regulation Of Metabolic Process Positive Regulation Of Gene Expression Mononuclear Cell Differentiation Apoptotic Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Skeletal Myofibril Assembly Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway C-terminal Protein Lipidation Developmental Process Protein-containing Complex Binding Negative Regulation Of RNA Metabolic Process Leukocyte Differentiation Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Autophagosome Assembly Negative Regulation Of Myoblast Fusion Negative Stranded Viral RNA Replication Autophagosome Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nuclear Receptor-mediated Signaling Pathway Apoptotic Process Response To Estradiol Negative Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Editing Complex Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Negative Regulation Of Dendrite Extension
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