DEDD2 and RBFOX2

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		DEDD2	RBFOX2
Gene Name		death effector domain containing 2	RNA binding protein, fox-1 homolog (C. elegans) 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	DNA Binding Protein Binding Receptor Signaling Complex Scaffold Activity	Nucleotide Binding Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding Transcription Factor Binding Poly(A) RNA Binding
	Biological Process	Transcription, DNA-templated RNA Processing Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors RRNA Catabolic Process Cellular Homeostasis Apoptotic Nuclear Changes Intracellular Signal Transduction Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Regulation Of Definitive Erythrocyte Differentiation RNA Metabolic Process Radial Glia Guided Migration Of Purkinje Cell Intracellular Estrogen Receptor Signaling Pathway Regulation Of Cell Proliferation Negative Regulation Of Transcription, DNA-templated Dendrite Morphogenesis Neuromuscular Process Controlling Balance
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: CASP10 CASP8 CDCA7L CDK6 CFLAR DEDD GTF3C3 HNRNPAB NR2E3 RBFOX2 RHOXF2	50 interactors: APH1A ATN1 ATXN1 ATXN1L BOLL BRD7 C1orf94 CAMK2B CHAF1A DAB1 DAZAP2 DDX5 DEDD2 DMRTB1 ELAVL1 ELAVL2 ESR1 ESR2 GLIS2 GTF2A1L HNRNPAB HNRNPF HNRNPH2 HNRNPK KHDRBS1 MAGED1 MAPK1IP1L MED7 NAF1 NR2E3 POLR3D PSMA3 PSMF1 PTBP1 QKI RBFOX1 RBM22 RBM23 RBM42 RBPMS RERE RHOXF2 RNF8 SF3A1 SMN1 SNRPC TOLLIP U2AF2 VAC14 ZNF137P
Entrez ID		162989	23543
HPRD ID		10868	15231
Ensembl ID		ENSG00000160570	ENSG00000100320
Uniprot IDs		Q8WXF8	O43251
PDB IDs			2CQ3
Enriched GO Terms of Interacting Partners?		Regulation Of Necroptotic Process Regulation Of Necrotic Cell Death Tissue Development Regulation Of Myeloid Cell Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Intracellular Receptor Signaling Pathway Organ Development Regulation Of Erythrocyte Differentiation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Gene Expression Regulation Of Cell Proliferation Apoptotic Signaling Pathway Cell Dedifferentiation Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Development Programmed Cell Death Activation Of Cysteine-type Endopeptidase Activity System Development Regulation Of Metabolic Process Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Cell Death Death Extrinsic Apoptotic Signaling Pathway Regulation Of Transcription, DNA-templated Zymogen Activation Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Rhodopsin Gene Expression Negative Regulation Of Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Rhodopsin Gene Expression Negative Regulation Of Myoblast Fusion Multicellular Organismal Development Positive Regulation Of Peptidase Activity Cell Differentiation Negative Regulation Of Gene Expression Radial Glia Guided Migration Of Purkinje Cell Regulation Of Definitive Erythrocyte Differentiation Anatomical Structure Development Negative Regulation Of Biosynthetic Process	Gene Expression RNA Metabolic Process RNA Processing Cellular Nitrogen Compound Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Processing Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process MRNA Metabolic Process Regulation Of RNA Metabolic Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Negative Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Regulation Of RNA Splicing Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cellular Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of MRNA Processing Positive Regulation Of Cellular Protein Metabolic Process Metabolic Process DNA-templated Transcription, Initiation
Tagcloud ?		annotation atra bindings birc3 braf casp4 casp8 changed effector erk expressions fas fate fenretinide fewer hspa1a huh7 inducing mek participated profiled raf ras rxralpha sosc2 tnfaip3 tnfalpha traf2 uses	aberrant altering biology discussing editing emerging fmrp focus fus hub huc hud hur neurological nova players polyadenylation processing qki rbp rbps rna rnas roles splicing steps surveillance translational
Tagcloud (Difference) ?		annotation atra bindings birc3 braf casp4 casp8 changed effector erk expressions fas fate fenretinide fewer hspa1a huh7 inducing mek participated profiled raf ras rxralpha sosc2 tnfaip3 tnfalpha traf2 uses	aberrant altering biology discussing editing emerging fmrp focus fus hub huc hud hur neurological nova players polyadenylation processing qki rbp rbps rna rnas roles splicing steps surveillance translational
Tagcloud (Intersection) ?