TRIP4 and THRB

Number of citations of the paper that reports this interaction (PubMedID 10454579)
57

Data Source:
BioGRID (two hybrid)
HPRD (in vivo)

		TRIP4	THRB
Description		thyroid hormone receptor interactor 4	thyroid hormone receptor beta
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Nuclear Body Neuromuscular Junction Protein-containing Complex RQC-trigger Complex	Chromatin Nucleus Nucleoplasm Nuclear Body RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protease Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Nuclear Receptor Binding Protein Kinase Binding Nuclear Estrogen Receptor Binding Histone Acetyltransferase Binding Ubiquitin-like Protein Ligase Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Enzyme Binding Chromatin DNA Binding Sequence-specific DNA Binding Metal Ion Binding Thyroid Hormone Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Estrogen Receptor Signaling Pathway Ribosome Disassembly Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Rescue Of Stalled Ribosome Ribosome-associated Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Sensory Perception Of Sound Negative Regulation Of Female Receptivity Regulation Of Heart Contraction Female Courtship Behavior Animal Organ Morphogenesis Cell Differentiation MRNA Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Retinal Cone Cell Development Retinoic Acid Receptor Signaling Pathway Type I Pneumocyte Differentiation Cellular Response To Thyroid Hormone Stimulus Retinal Cone Cell Apoptotic Process
Pathways		ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Nuclear Receptor transcription pathway SUMOylation of intracellular receptors
Drugs			Liothyronine Levothyroxine Dextrothyroxine Amiodarone Liotrix [3,5-Dibromo-4-(4-Hydroxy-3-Phenethylcarbamoyl-Phenoxy)-Phenyl]-Acetic Acid KB-141 2-[4-(4-Hydroxy-3-Isopropyl-Phenoxy)-3,5-Dimethyl-Phenyl]-2h-[1,2,4]Triazine-3,5-Dione Tiratricol GC-24 Eprotirome MB07811 Sobetirome 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE Thyroid, porcine
Diseases
GWAS		Alzheimer's disease (late onset) ( 24162737) Neuroticism ( 29255261)	Acne (severe) ( 24927181) Amyotrophic lateral sclerosis (sporadic) ( 24529757) antipsychotic drug dosage in schizophrenia or schizoaffective disorder ( 26821981) Appendicular lean mass ( 33097823) Asthma ( 29273806) Atrial fibrillation ( 30061737 29892015) Carotid intima media thickness x smoking interaction ( 32117412) Chronotype ( 30696823) Colorectal cancer ( 34062886) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Erythrocyte cadmium concentration ( 27005419) Extremely high intelligence ( 29520040) Familial squamous cell lung carcinoma ( 29924316) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Height ( 28552196) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 20139978 32888494 27863252 29403010 28017375) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 29403010 20139978 32888494 27863252 28017375) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Midgestational cytokine/chemokine levels (maternal genetic effect) ( 30134952) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Myopia ( 27182965) Platelet distribution width ( 32888494) PR interval ( 32439900) Red blood cell count ( 29403010 32888494 27863252) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252 32888494) Refractive error ( 32231278) Relative wall thickness x antihypertensive treatment interaction ( 31407531) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure in sickle cell anemia ( 24058526) Triglyceride levels ( 32203549 32154731)
Interacting Genes		23 interacting genes: AR ASCC2 ASCC3 CREBBP EP300 ESR1 ESR2 GTF2A1 JUN NCOA1 NEK6 NFKB1 NR2F2 PAX9 PPARG RARA RELA RXRA SRF TBP THRB UBC XBP1	58 interacting genes: ACVR1 ADAT3 ANP32A ATF2 BRD8 BTG1 C1D CAMK2B CCND1 CNOT1 COPS2 CTCF ESR1 FOXO1 HDAC2 HDAC3 HMGN3 JMJD1C LRIF1 MECR MED1 MED21 MMS19 MPG NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NR2F6 NRBF2 NRIP1 NSD1 PPARGC1A PPARGC1B PRKDC PRMT1 PRMT2 PSMC3IP PSMC5 RANBP9 RARA ROBO4 RXRA RXRB RXRG SRC TBL1X TP53 TRIP10 TRIP12 TRIP13 TRIP4 TRIP6 TSG101 UBE2I ZNHIT3
Entrez ID		9325	7068
HPRD ID		05140	07521
Ensembl ID		ENSG00000103671	ENSG00000151090
Uniprot IDs		Q15650	A0A024R2I8 P10828
PDB IDs		2E5O 8ALZ 8YEW 8YEY 8YFI 8YFJ 8YXW 8YXX	1BSX 1N46 1NAX 1NQ0 1NQ1 1NQ2 1NUO 1Q4X 1R6G 1XZX 1Y0X 2J4A 2NLL 2PIN 3D57 3GWS 3IMY 3JZC 4ZO1 6KKB 6KKE 6KNU 6KNV 6KNW 7WLX 7WMG 7WMH 7WMJ 7WML 7WMN 7WMO 8RQN
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleoplasm Transcription Coactivator Binding Nuclear Receptor Activity Positive Regulation Of RNA Metabolic Process Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding Negative Regulation Of DNA-templated Transcription Intracellular Receptor Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Hormone-mediated Signaling Pathway Regulation Of MiRNA Metabolic Process Chromatin Binding DNA-binding Transcription Factor Activity Nucleobase-containing Compound Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Nuclear Receptor-mediated Signaling Pathway DNA Binding Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Hormone Regulation Of MiRNA Transcription Nucleic Acid Metabolic Process Regulation Of RNA Metabolic Process Transcription Regulator Complex Chromatin DNA Binding Transcription Cis-regulatory Region Binding MRNA Transcription By RNA Polymerase II Enzyme Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Response To Lipid Nucleus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific MRNA Transcription Positive Regulation Of Metabolic Process RNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process	Nuclear Thyroid Hormone Receptor Binding Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Estrogen Receptor Binding Nuclear Receptor Binding Nuclear Receptor-mediated Signaling Pathway Nuclear Retinoic Acid Receptor Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Hormone-mediated Signaling Pathway Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Enzyme Binding Chromatin Regulation Of Macromolecule Metabolic Process Transcription Coregulator Activity Transcription Coactivator Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process MRNA Transcription Chromatin Binding Negative Regulation Of Macromolecule Biosynthetic Process Transcription Corepressor Activity Negative Regulation Of Biosynthetic Process Chromatin Organization MRNA Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Rhythmic Process Transcription Repressor Complex Nuclear Retinoid X Receptor Binding
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