ZNF750 and RCOR1

Number of citations of the paper that reports this interaction (PubMedID 25228645)
42

Data Source:
BioGRID (far western blotting)

		ZNF750	RCOR1
Description		zinc finger protein 750	REST corepressor 1
Image
GO Annotations	Cellular Component	Nucleus	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Regulator Complex Transcription Repressor Complex Histone Methyltransferase Complex DNA Repair Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Zinc Ion Binding Metal Ion Binding Promoter-specific Chromatin Binding	Chromatin Binding Transcription Corepressor Activity Protein Binding Enzyme Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Epidermis Development Positive Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Cell Differentiation Membrane Biogenesis Positive Regulation Of Transcription By RNA Polymerase II Establishment Of Skin Barrier Positive Regulation Of Ceramide Biosynthetic Process	Chromatin Organization Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription
Pathways		Generic Transcription Pathway	HDACs deacetylate histones Regulation of PTEN gene transcription Potential therapeutics for SARS Factors involved in megakaryocyte development and platelet production
Drugs
Diseases		Seborrhea-like dermatitis with psoriasiform element
GWAS		Response to cognitive-behavioural therapy in anxiety and major depressive disorders ( 31123309)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Body mass index ( 26426971) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Homeostasis model assessment of insulin resistance ( 33381925) Immature fraction of reticulocytes ( 27863252 32888494) LDL cholesterol levels in HIV infection ( 33109212) Mean platelet volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Multiple sclerosis ( 31604244) Platelet count ( 27863252 22139419 32888494) Plateletcrit ( 27863252 32888494) Tinnitus ( 33742053)
Interacting Genes		5 interacting genes: CTBP1 CTBP2 KDM1A KLF4 RCOR1	14 interacting genes: CEBPA FOXK2 GFI1B H3-4 HDAC2 KDM1A PHF21A REST SMARCE1 SNAI1 SUB1 SUMO2 UBC ZNF750
Entrez ID		79755	23186
HPRD ID		08588	09645
Ensembl ID		ENSG00000141579	ENSG00000089902
Uniprot IDs		Q32MQ0	Q9UKL0
PDB IDs		8SXM	2IW5 2UXN 2UXX 2V1D 2X0L 2XAF 2XAG 2XAH 2XAJ 2XAQ 2XAS 2Y48 3ZMS 3ZMT 3ZMU 3ZMV 3ZMZ 3ZN0 3ZN1 4BAY 4KUM 4UV8 4UV9 4UVA 4UVB 4UVC 4UXN 4XBF 5H6Q 5H6R 5L3B 5L3C 5L3D 5L3E 5L3F 5L3G 5LBQ 5LGN 5LGT 5LGU 5LHG 5LHH 5LHI 5X60 5YJB 6K3E 6KGK 6KGL 6KGM 6KGN 6S35 6TE1 6TUY 6VYP 6W4K 6WC6 7CDC 7CDD 7CDE 7CDF 7CDG 7ZRY 8BOP 8BOX 8F2Z 8F30 8F59 8F6S 8FDV 8FJ4 8FJ7 8FQJ 8FRI 8FRQ 8FRV 8FSK 8GJ6 8JF5 8Q1G 8Q1H 8Q1J 8UL6 8UL8 8ULB 8ULC 8UMQ 8UNI 8UOM 8VOJ 8VPQ 8VRT 8YM7 9DTQ 9DWU 9EL7 9EL8 9ELA 9FWG
Enriched GO Terms of Interacting Partners?		Transcription Corepressor Activity Transcription Coregulator Binding Transcription Repressor Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Fat Cell Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Repair Complex White Fat Cell Differentiation DNA-binding Transcription Factor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Viral Genome Replication LncRNA Binding Transcription Regulator Complex Histone Methyltransferase Complex Negative Regulation Of Macromolecule Biosynthetic Process NAD Binding Negative Regulation Of Biosynthetic Process Transcription Coactivator Activity Negative Regulation Of Transcription By RNA Polymerase II Cell Differentiation Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Transcription Corepressor Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Negative Regulation Of Metabolic Process Cellular Developmental Process Promoter-specific Chromatin Binding Regulation Of DNA-templated Transcription Chromatin Binding Regulation Of RNA Biosynthetic Process Oxidoreductase Activity RNA Polymerase II Sequence-specific DNA-binding Transcription Factor Recruiting Activity Negative Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Cell Population Proliferation Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Muscle Hyperplasia Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Negative Regulation Of Cell Population Proliferation Viral Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Blastocyst Development Mesodermal Cell Fate Determination Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin Organization Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Metabolic Process Regulation Of Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleus Negative Regulation Of Biosynthetic Process Chromatin Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Positive Regulation Of Stem Cell Population Maintenance Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Developmental Process Promoter-specific Chromatin Binding Regulation Of Cell Development Regulation Of Stem Cell Population Maintenance Transcription Regulator Complex Positive Regulation Of Cell Differentiation Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Repair Complex Protein Tag Activity Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Chromatin Remodeling Regulation Of Metabolic Process
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