MS4A1 and SLC10A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MS4A1	SLC10A1
Description		membrane spanning 4-domains A1	solute carrier family 10 member 1
Image
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Plasma Membrane Raft Extracellular Exosome	Plasma Membrane Membrane Basolateral Plasma Membrane
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Immunoglobulin Binding MHC Class II Protein Complex Binding Identical Protein Binding	Virus Receptor Activity Protein Binding Bile Acid:sodium Symporter Activity Bile Acid Transmembrane Transporter Activity Symporter Activity
	Biological Process	Store-operated Calcium Entry Humoral Immune Response Cell Surface Receptor Signaling Pathway Response To Bacterium B Cell Differentiation B Cell Proliferation B Cell Activation B Cell Receptor Signaling Pathway Protein Tetramerization Calcium Ion Import Into Cytosol Positive Regulation Of Calcium Ion Import Across Plasma Membrane	Monoatomic Ion Transport Sodium Ion Transport Lipid Transport Bile Acid And Bile Salt Transport Response To Nutrient Levels Response To Estrogen Response To Ethanol Symbiont Entry Into Host Cell Transmembrane Transport Cellular Response To Xenobiotic Stimulus
Pathways			Recycling of bile acids and salts
Drugs		Rituximab Ibritumomab tiuxetan Tositumomab Ofatumumab Obinutuzumab Technetium Tc-99m nofetumomab merpentan Ublituximab Ocrelizumab Mosunetuzumab Odronextamab	Bulevirtide
Diseases
GWAS		Recurrent major depressive disorder ( 29317602)	Daytime sleep phenotypes ( 27126917) Metabolite levels ( 23823483) Triglyceride levels ( 30108155)
Interacting Genes		41 interacting genes: ACKR2 AQP6 CD40 CERS4 CLEC14A CREB3 CREB3L1 CSNK2A1 CSNK2A2 FAM209A FCRL3 FYN GORAB GPR42 HSD17B11 HSD17B13 IL7R KASH5 LCK LEUTX LMNA LYN MDM2 MMD MTIF3 REEP2 REEP4 RNF19B RNF5 SLC10A1 SLC10A6 SLC18A1 SLC35H1 SLC71A2 THAP4 TMEM31 TMEM72 TMEM82 TMPPE TMX2 TSPO2	115 interacting genes: ABHD16A ACSL5 AGPAT3 APOL3 ARL6IP6 ASGR1 ATP13A1 ATP6V0B BMP10 BTN2A2 C2 C3orf52 C8A CDIPT CFHR5 CFTR CLDN19 CMTM3 COX20 CXCL9 CYB5B CYB5R3 DERL1 DGAT2L6 EMC6 EMD FA2H FAM241B FAXDC2 FCER1G FDFT1 FKBP8 FXYD3 FXYD6 FXYD6-FXYD2 GAST GDE1 GIMAP5 GOSR2 GPR151 GPR152 IFITM2 IFITM3 IFTAP INSIG2 LNPEP LRP10 LSS MAL MALL MFSD6 MS4A1 MYADML2 NEU1 NINJ2 NKG7 ORMDL1 ORMDL2 ORMDL3 OTOP3 PEDS1-UBE2V1 PEX16 PKMYT1 PMP22 RABAC1 RTP2 RUSF1 SACM1L SCAMP4 SEC22A SELENOK SERP1 SFT2D1 SFT2D2 SFXN1 SLC12A7 SLC16A13 SLC25A46 SLC29A2 SLC35E4 SLC38A1 SLC38A7 SLC41A1 SLC66A2 SLC7A3 SMPD2 STATH STX12 STX7 TAP1 TFRC TMBIM1 TMEM119 TMEM120B TMEM121 TMEM147 TMEM222 TMEM234 TMEM239 TMEM242 TMEM60 TMEM97 TMUB2 TOMM6 TRARG1 TSPO2 TVP23B UBIAD1 UNC50 UPK1B VAMP3 VAPB YIF1A YIPF4 YIPF6
Entrez ID		931	6554
HPRD ID		00204	01672
Ensembl ID		ENSG00000156738	ENSG00000100652
Uniprot IDs		P11836	B2RA41 Q14973
PDB IDs		2OSL 3BKY 3PP4 6VJA 6Y90 6Y92 6Y97 6Y9A 8VGN 8VGO	7FCI 7PQG 7PQQ 7VAD 7VAG 7WSI 7ZYI 8HRX 8HRY 8RQF
Enriched GO Terms of Interacting Partners?		Membrane Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Protein Kinase CK2 Complex Steroid Dehydrogenase Activity CD8 Receptor Binding Bile Acid:sodium Symporter Activity Fc-gamma Receptor Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Lymphocyte Activation Lymphocyte Proliferation Mononuclear Cell Proliferation B Cell Proliferation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway T Cell Costimulation CD4 Receptor Binding Non-membrane Spanning Protein Tyrosine Kinase Activity Endoplasmic Reticulum Endoplasmic Reticulum Membrane Peptidyl-tyrosine Phosphorylation Monocarboxylic Acid Transport Phospholipase Activator Activity Negative Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Cell Activation Fc Receptor Signaling Pathway Leukocyte Proliferation T Cell Receptor Binding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of B Cell Proliferation Organic Hydroxy Compound Transport Protein Binding Response To Xenobiotic Stimulus Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Adaptive Immune Response Phosphatidylinositol 3-kinase Binding Negative Regulation Of Apoptotic Process Transmembrane Transport Protein Kinase Activity Negative Regulation Of Programmed Cell Death Stimulatory C-type Lectin Receptor Signaling Pathway Phospholipase Binding Cellular Response To Lectin Bile Acid And Bile Salt Transport Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Lymphocyte Activation Nuclear Envelope Organization	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Sterol Biosynthetic Process Lipid Biosynthetic Process Protein Binding Endomembrane System Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Cholesterol Biosynthetic Process SNAP Receptor Activity Negative Regulation Of Sphingolipid Biosynthetic Process Membrane Organization Serine Palmitoyltransferase Complex Establishment Of Protein Localization To Membrane Establishment Of Protein Localization Cellular Localization Plasma Membrane Steroid Biosynthetic Process Vesicle-mediated Transport Lipid Metabolic Process Membrane Docking Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Ceramide Metabolic Process Myelination Axon Ensheathment Vesicle Fusion Organelle Membrane Fusion Membrane Fusion Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Golgi Membrane Protein Insertion Into Membrane Protein Transport Regulation Of Ceramide Biosynthetic Process Regulation Of Sphingolipid Biosynthetic Process Nitric-oxide Synthase Complex Transmembrane Transport Organelle Localization By Membrane Tethering Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Lysosomal Membrane Sterol Metabolic Process SNARE Complex Organelle Fusion Sphingomyelin Metabolic Process Amino Acid Transmembrane Transport Regulation Of Membrane Lipid Metabolic Process Nuclear Inner Membrane Phospholipid Metabolic Process Nitrite Reductase (NO-forming) Activity
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