ADAM2 and CD9

Number of citations of the paper that reports this interaction (PMID 10518536)
25

Data Source:
HPRD (in vivo)

		ADAM2	CD9
Gene Name		ADAM metallopeptidase domain 2	CD9 molecule
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Platelet Alpha Granule Membrane Vesicle Extracellular Vesicular Exosome
	Molecular Function	Metalloendopeptidase Activity Integrin Binding Metallopeptidase Activity Zinc Ion Binding	Integrin Binding Protein Binding
	Biological Process	Proteolysis Cell Adhesion Single Fertilization Binding Of Sperm To Zona Pellucida Fusion Of Sperm To Egg Plasma Membrane Visual Learning Adult Behavior Multicellular Organism Reproduction	Platelet Degranulation Movement Of Cell Or Subcellular Component Cell Adhesion Single Fertilization Fusion Of Sperm To Egg Plasma Membrane Brain Development Blood Coagulation Negative Regulation Of Cell Proliferation Pathogenesis Response To Water Deprivation Oligodendrocyte Development Platelet Activation Paranodal Junction Assembly Multicellular Organism Reproduction
Pathways		Interaction With The Zona Pellucida Fertilization	Uptake and actions of bacterial toxins Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Fertilization Sperm:Oocyte Membrane Binding Uptake and function of diphtheria toxin
Drugs
Diseases
GWAS			Mean platelet volume ( 22139419) Paclitaxel-induced neuropathy ( 23776197) Platelet counts ( 22139419)
Protein-Protein Interactions		2 interactors: CD9 CLGN	22 interactors: ADAM2 ADRB2 CD19 CD36 CD38 CD53 CD59 CD63 CD81 CLN8 HBEGF IGSF8 ITGA2 ITGA3 ITGA5 ITGB1 KIT PRKCA PTGFRN SERPINH1 TSPAN4 VKORC1
Entrez ID		2515	928
HPRD ID		03322	00880
Ensembl ID		ENSG00000104755	ENSG00000010278
Uniprot IDs		B4DWY7 Q6P2G0 Q99965	B4DK09 P21926
PDB IDs
Enriched GO Terms of Interacting Partners?		Single Fertilization Fertilization Response To Water Deprivation Sexual Reproduction Fusion Of Sperm To Egg Plasma Membrane Paranodal Junction Assembly Plasma Membrane Fusion Reproduction Myelin Assembly Single Organism Reproductive Process Reproductive Process Oligodendrocyte Development Binding Of Sperm To Zona Pellucida Sperm-egg Recognition Cell-cell Recognition Platelet Degranulation Oligodendrocyte Differentiation Cellular Component Assembly Glial Cell Development Cell-cell Junction Assembly Cell Recognition Membrane Fusion Myelination Axon Ensheathment Glial Cell Differentiation Platelet Activation Cell Junction Assembly Pathogenesis Cell-cell Junction Organization	Wound Healing Blood Coagulation Hemostasis Response To Wounding Regulation Of Body Fluid Levels Response To Stress Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Regulation Of Immune System Process Regulation Of Protein Metabolic Process Learning Or Memory Cognition Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cell Adhesion Mediated By Integrin Positive Regulation Of Cell Proliferation Cell Migration Cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Regulation Of Cell Migration Extracellular Matrix Organization Associative Learning Extracellular Structure Organization Locomotion Cell Motility Positive Regulation Of Signal Transduction Regulation Of Cell Adhesion Positive Regulation Of Epithelial Cell Migration Regulation Of Cellular Amino Acid Metabolic Process Tissue Development Cell-substrate Adhesion Positive Regulation Of Endocytosis Leukocyte Migration Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Single-organism Behavior Mesodermal Cell Differentiation Movement Of Cell Or Subcellular Component Positive Regulation Of Cell-substrate Adhesion Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling
Tagcloud ?		adam1a adam3 calmegin calnexin calr calr3 calreticulin calsperin canx chaperones clgn client contraception contrasting cooperate fertility fertilization germ infertile infertility lectin nascent oviduct pave pellucida sperm unexplained uterus zona	accessibility agvhd allergy allobmt analogous buffy cationic cd23 cd25 clarified coat destructive dr eg2 eosinophil eosinophilia eosinophilic eosinophils epitope fog formaldehyde intravenously methylprednisolone myristate octylglucopyranoside pbes recognizing rhil transplanted
Tagcloud (Difference) ?		adam1a adam3 calmegin calnexin calr calr3 calreticulin calsperin canx chaperones clgn client contraception contrasting cooperate fertility fertilization germ infertile infertility lectin nascent oviduct pave pellucida sperm unexplained uterus zona	accessibility agvhd allergy allobmt analogous buffy cationic cd23 cd25 clarified coat destructive dr eg2 eosinophil eosinophilia eosinophilic eosinophils epitope fog formaldehyde intravenously methylprednisolone myristate octylglucopyranoside pbes recognizing rhil transplanted
Tagcloud (Intersection) ?