FANK1 and LZTR1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		FANK1	LZTR1
Description		fibronectin type III and ankyrin repeat domains 1	leucine zipper like post translational regulator 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Cilium Ciliary Basal Body Cell Projection Ciliary Base	Endosome Golgi Apparatus Endomembrane System Membrane Cul3-RING Ubiquitin Ligase Complex Recycling Endosome Recycling Endosome Membrane
	Molecular Function	Protein Binding	Protein Binding Small GTPase Binding
	Biological Process	Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of DNA-binding Transcription Factor Activity	Protein Ubiquitination Negative Regulation Of Ras Protein Signal Transduction
Pathways
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Visceral fat ( 22589738) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		4 interacting genes: LZTR1 RYBP TRIM55 TRIM63	54 interacting genes: AATF ANKRD53 ASB12 BMPR1B CEBPZ CHAF1A CNOT6L E2F8 EHMT1 FANK1 GABARAPL2 HCLS1 HDAC4 HRAS IKBKG KDM2B KRAS L3MBTL3 MCM3 MED16 MED7 MYBL2 NR1H3 NRAS PAPOLG PARP1 POLR1B POLR2B POLR2E RAI1 RERE RUVBL1 SCMH1 SND1 SP100 SREBF2 SSX4 STAT1 SUGP2 TAF11 TBX2 TCF19 TFAP2B TRIM5 TUBGCP4 WWP1 ZBTB1 ZNF137P ZNF175 ZNF451 ZNF490 ZNF584 ZNF714 ZZZ3
Entrez ID		92565	8216
HPRD ID		09945	08992
Ensembl ID		ENSG00000203780	ENSG00000099949
Uniprot IDs		Q8TC84	A0A384NL67 Q8N653
PDB IDs
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Ubiquitination Protein Modification By Small Protein Conjugation Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Diapedesis Skeletal Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy Protein Modification Process Negative Regulation Of Catabolic Process Ubiquitin Protein Ligase Activity Microtubule Muscle Atrophy Titin Binding Contractile Muscle Fiber Negative Regulation Of Ras Protein Signal Transduction Zinc Ion Binding Leukocyte Migration Involved In Inflammatory Response Macrophage Migration Negative Regulation Of Glycolytic Process M Band Negative Regulation Of ATP Metabolic Process PcG Protein Complex	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process DNA Binding Zinc Ion Binding Negative Regulation Of Metabolic Process Transcription By RNA Polymerase II DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nuclear Body Nucleic Acid Metabolic Process Nucleolus Ribonucleoside Binding Transcription Coactivator Activity Chromatin Organization RNA Metabolic Process Regulation Of Transcription Initiation By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex DNA-directed RNA Polymerase Activity Regulation Of DNA-templated Transcription Initiation Chromo Shadow Domain Binding Chromatin Remodeling 5'-3' RNA Polymerase Activity
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