CRLF1 and CNTFR

Number of citations of the paper that reports this interaction (PMID 10966616)
40

Data Source:
HPRD (in vivo, in vitro)

		CRLF1	CNTFR
Gene Name		cytokine receptor-like factor 1	ciliary neurotrophic factor receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space CRLF-CLCF1 Complex	Extrinsic Component Of Membrane Anchored Component Of Membrane Ciliary Neurotrophic Factor Receptor Complex CNTFR-CLCF1 Complex
	Molecular Function	Receptor Activity Cytokine Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Cytokine Binding Protein Heterodimerization Activity	Ciliary Neurotrophic Factor Receptor Activity Receptor Binding Cytokine Binding
	Biological Process	Ureteric Bud Development Positive Regulation Of Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Motor Neuron Apoptotic Process	Suckling Behavior Brainstem Development Signal Transduction Nervous System Development Sex Differentiation Positive Regulation Of Cell Proliferation Negative Regulation Of Neuron Apoptotic Process Skeletal Muscle Organ Development Ciliary Neurotrophic Factor-mediated Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: CLCF1 CNTFR	9 interactors: APPBP2 CLCF1 CNTF CRLF1 HN1L IL6ST KRTAP4-12 LIFR PLSCR1
Entrez ID		9244	1271
HPRD ID		09177	00348
Ensembl ID		ENSG00000006016	ENSG00000122756
Uniprot IDs		O75462	P26992
PDB IDs			1UC6
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Death Regulation Of Neuron Apoptotic Process Regulation Of Neuron Death Cytokine-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Positive Regulation Of Astrocyte Differentiation Response To Cytokine Positive Regulation Of Isotype Switching To IgE Isotypes Brainstem Development Positive Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Suckling Behavior Positive Regulation Of Isotype Switching Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Astrocyte Differentiation Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Isotype Switching Positive Regulation Of Immunoglobulin Mediated Immune Response Positive Regulation Of Immunoglobulin Production Positive Regulation Of Glial Cell Differentiation Positive Regulation Of B Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Apoptotic Process Regulation Of Cell Proliferation Regulation Of Cell Death JAK-STAT Cascade Positive Regulation Of Gliogenesis Regulation Of B Cell Proliferation Positive Regulation Of JAK-STAT Cascade Regulation Of DNA Recombination Positive Regulation Of B Cell Activation Cellular Response To Organic Substance Regulation Of Glial Cell Differentiation Regulation Of JAK-STAT Cascade Feeding Behavior B Cell Differentiation Regulation Of Gliogenesis Nervous System Development Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Response To Organic Substance Positive Regulation Of DNA Metabolic Process Skeletal Muscle Organ Development Positive Regulation Of Adaptive Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation B Cell Activation	Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of JAK-STAT Cascade Regulation Of JAK-STAT Cascade Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M-mediated Signaling Pathway Response To Cytokine Positive Regulation Of Cell Proliferation Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Astrocyte Differentiation Cytokine-mediated Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Cellular Response To Cytokine Stimulus Negative Regulation Of Neuron Apoptotic Process Regulation Of Cell Proliferation Negative Regulation Of Neuron Death Positive Regulation Of Protein Phosphorylation Regulation Of Astrocyte Differentiation Regulation Of Neuron Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Glial Cell Differentiation Regulation Of Neuron Death Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Positive Regulation Of Gliogenesis Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Glial Cell Differentiation Positive Regulation Of Protein Metabolic Process Response To Organic Substance Positive Regulation Of Signal Transduction Regulation Of Cell Activation Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Interleukin-11-mediated Signaling Pathway Regulation Of Signal Transduction Regulation Of Gliogenesis Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Cell Death Interleukin-27-mediated Signaling Pathway
Tagcloud ?		27ralpha apc b9 castelman cd4 clf composite cytokine ebi3 ebv homolog ig igg1 igg2c igm modulates myeloma nk p28 plasmacytoma prompted secreted soluble sustains switching th1 th17 unlike unresponsive	acidic afgf albino bfgf ciliary college dystrophy fgf fgfr1 fibrillary gfap hybridizations igfr inherited injured minimize neurotrophic persisted photoreceptor prompt rcs retina royal slower subretinal surgeons trkb vicinity
Tagcloud (Difference) ?		27ralpha apc b9 castelman cd4 clf composite cytokine ebi3 ebv homolog ig igg1 igg2c igm modulates myeloma nk p28 plasmacytoma prompted secreted soluble sustains switching th1 th17 unlike unresponsive	acidic afgf albino bfgf ciliary college dystrophy fgf fgfr1 fibrillary gfap hybridizations igfr inherited injured minimize neurotrophic persisted photoreceptor prompt rcs retina royal slower subretinal surgeons trkb vicinity
Tagcloud (Intersection) ?