CRLF1 and CLCF1

Number of citations of the paper that reports this interaction (PMID 10966616)
40

Data Source:
HPRD (in vivo, in vitro)

		CRLF1	CLCF1
Gene Name		cytokine receptor-like factor 1	cardiotrophin-like cytokine factor 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space CRLF-CLCF1 Complex	Extracellular Region Extracellular Vesicular Exosome CRLF-CLCF1 Complex CNTFR-CLCF1 Complex
	Molecular Function	Receptor Activity Cytokine Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Cytokine Binding Protein Heterodimerization Activity	Receptor Binding Cytokine Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Growth Factor Activity Protein Heterodimerization Activity
	Biological Process	Ureteric Bud Development Positive Regulation Of Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Motor Neuron Apoptotic Process	Positive Regulation Of Immunoglobulin Production Cell Surface Receptor Signaling Pathway JAK-STAT Cascade Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway B Cell Differentiation Positive Regulation Of B Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Isotype Switching To IgE Isotypes Positive Regulation Of Astrocyte Differentiation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: CLCF1 CNTFR	2 interactors: CNTFR CRLF1
Entrez ID		9244	23529
HPRD ID		09177	09643
Ensembl ID		ENSG00000006016	ENSG00000175505
Uniprot IDs		O75462	Q9UBD9
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Death Regulation Of Neuron Apoptotic Process Regulation Of Neuron Death Cytokine-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Positive Regulation Of Astrocyte Differentiation Response To Cytokine Positive Regulation Of Isotype Switching To IgE Isotypes Brainstem Development Positive Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Suckling Behavior Positive Regulation Of Isotype Switching Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Astrocyte Differentiation Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Isotype Switching Positive Regulation Of Immunoglobulin Mediated Immune Response Positive Regulation Of Immunoglobulin Production Positive Regulation Of Glial Cell Differentiation Positive Regulation Of B Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Apoptotic Process Regulation Of Cell Proliferation Regulation Of Cell Death JAK-STAT Cascade Positive Regulation Of Gliogenesis Regulation Of B Cell Proliferation Positive Regulation Of JAK-STAT Cascade Regulation Of DNA Recombination Positive Regulation Of B Cell Activation Cellular Response To Organic Substance Regulation Of Glial Cell Differentiation Regulation Of JAK-STAT Cascade Feeding Behavior B Cell Differentiation Regulation Of Gliogenesis Nervous System Development Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Response To Organic Substance Positive Regulation Of DNA Metabolic Process Skeletal Muscle Organ Development Positive Regulation Of Adaptive Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation B Cell Activation	Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Death Regulation Of Neuron Apoptotic Process Regulation Of Neuron Death Negative Regulation Of Motor Neuron Apoptotic Process Ciliary Neurotrophic Factor-mediated Signaling Pathway Brainstem Development Positive Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Suckling Behavior Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Apoptotic Process Regulation Of Cell Proliferation Regulation Of Cell Death Positive Regulation Of JAK-STAT Cascade Regulation Of JAK-STAT Cascade Feeding Behavior Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development Skeletal Muscle Organ Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Kidney Epithelium Development Organ Development
Tagcloud ?		27ralpha apc b9 castelman cd4 clf composite cytokine ebi3 ebv homolog ig igg1 igg2c igm modulates myeloma nk p28 plasmacytoma prompted secreted soluble sustains switching th1 th17 unlike unresponsive
Tagcloud (Difference) ?		27ralpha apc b9 castelman cd4 clf composite cytokine ebi3 ebv homolog ig igg1 igg2c igm modulates myeloma nk p28 plasmacytoma prompted secreted soluble sustains switching th1 th17 unlike unresponsive
Tagcloud (Intersection) ?