ANKRD40 and AHCY

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ANKRD40	AHCY
Gene Name		ankyrin repeat domain 40	adenosylhomocysteinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component	Nucleus Cytoplasm Cytosol Melanosome Neuron Projection Extracellular Vesicular Exosome
	Molecular Function	Molecular_function	Adenosylhomocysteinase Activity Adenyl Nucleotide Binding Identical Protein Binding
	Biological Process	Biological_process	Sulfur Amino Acid Metabolic Process Response To Hypoxia Chronic Inflammatory Response To Antigenic Stimulus One-carbon Metabolic Process Xenobiotic Metabolic Process Response To Nutrient S-adenosylhomocysteine Catabolic Process Methylation S-adenosylmethionine Cycle Cellular Nitrogen Compound Metabolic Process Circadian Sleep/wake Cycle Small Molecule Metabolic Process Homocysteine Biosynthetic Process
Pathways			Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Sulfur amino acid metabolism Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Metabolism of amino acids and derivatives Phase II conjugation Methylation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs			Nicotinamide-Adenine-Dinucleotide (1\'r,2\'s)-9-(2-Hydroxy-3\'-Keto-Cyclopenten-1-Yl)Adenine 3\'-Oxo-Adenosine D-Eritadenine
Diseases
GWAS
Protein-Protein Interactions		4 interactors: AHCY PIN1 RAD23A SDCBP	7 interactors: ANKRD40 APPBP2 C1orf50 POT1 PXN TERF1 YWHAQ
Entrez ID		91369	191
HPRD ID		17502	01621
Ensembl ID		ENSG00000154945	ENSG00000101444
Uniprot IDs		A8IK34 Q6AI12	P23526
PDB IDs			1A7A 1LI4 3NJ4
Enriched GO Terms of Interacting Partners?		S-adenosylhomocysteine Catabolic Process Homocysteine Biosynthetic Process Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Extracellular Vesicular Exosome Assembly S-adenosylmethionine Cycle Regulation Of Extracellular Vesicular Exosome Assembly S-adenosylhomocysteine Metabolic Process Circadian Sleep/wake Cycle Homocysteine Metabolic Process Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Substrate-dependent Cell Migration, Cell Extension Purine Ribonucleoside Catabolic Process Chronic Inflammatory Response S-adenosylmethionine Metabolic Process Circadian Behavior Rhythmic Behavior Cellular Modified Amino Acid Catabolic Process Positive Regulation Of Viral Genome Replication Sulfur Amino Acid Biosynthetic Process Regulation Of MAPK Cascade Positive Regulation Of Organelle Assembly	Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Positive Regulation Of Organelle Organization Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of DNA Strand Elongation Regulation Of DNA Replication Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of Cellular Component Organization Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Formation Via Telomerase Telomere Maintenance Via Telomere Shortening Regulation Of Organelle Organization Regulation Of Chromosome Organization Telomere Capping Positive Regulation Of Helicase Activity Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase DNA Replication Replicative Cell Aging Negative Regulation Of Transferase Activity Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Telomere Maintenance Negative Regulation Of Biosynthetic Process Positive Regulation Of Microtubule Polymerization Signal Complex Assembly Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Microtubule Polymerization Focal Adhesion Assembly Positive Regulation Of Transferase Activity Cellular Component Assembly Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process
Tagcloud ?			advantageous altered biomarkers candidates crc differentially discover earlier intensities labeled lgals1 mining nbs near nitrobenzenesulfenyl occurring pair paired peaks profiling proteome proteomic quantified ran rcn1 stroma validated vim zyx
Tagcloud (Difference) ?			advantageous altered biomarkers candidates crc differentially discover earlier intensities labeled lgals1 mining nbs near nitrobenzenesulfenyl occurring pair paired peaks profiling proteome proteomic quantified ran rcn1 stroma validated vim zyx
Tagcloud (Intersection) ?