AHCY and ANKRD40

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		AHCY	ANKRD40
Gene Name		adenosylhomocysteinase	ankyrin repeat domain 40
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Melanosome Neuron Projection Extracellular Vesicular Exosome	Cellular_component
	Molecular Function	Adenosylhomocysteinase Activity Adenyl Nucleotide Binding Identical Protein Binding	Molecular_function
	Biological Process	Sulfur Amino Acid Metabolic Process Response To Hypoxia Chronic Inflammatory Response To Antigenic Stimulus One-carbon Metabolic Process Xenobiotic Metabolic Process Response To Nutrient S-adenosylhomocysteine Catabolic Process Methylation S-adenosylmethionine Cycle Cellular Nitrogen Compound Metabolic Process Circadian Sleep/wake Cycle Small Molecule Metabolic Process Homocysteine Biosynthetic Process	Biological_process
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Sulfur amino acid metabolism Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Metabolism of amino acids and derivatives Phase II conjugation Methylation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs		Nicotinamide-Adenine-Dinucleotide (1\'r,2\'s)-9-(2-Hydroxy-3\'-Keto-Cyclopenten-1-Yl)Adenine 3\'-Oxo-Adenosine D-Eritadenine
Diseases
GWAS
Protein-Protein Interactions		7 interactors: ANKRD40 APPBP2 C1orf50 POT1 PXN TERF1 YWHAQ	4 interactors: AHCY PIN1 RAD23A SDCBP
Entrez ID		191	91369
HPRD ID		01621	17502
Ensembl ID		ENSG00000101444	ENSG00000154945
Uniprot IDs		P23526	A8IK34 Q6AI12
PDB IDs		1A7A 1LI4 3NJ4
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Positive Regulation Of Organelle Organization Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of DNA Strand Elongation Regulation Of DNA Replication Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of Cellular Component Organization Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Formation Via Telomerase Telomere Maintenance Via Telomere Shortening Regulation Of Organelle Organization Regulation Of Chromosome Organization Telomere Capping Positive Regulation Of Helicase Activity Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase DNA Replication Replicative Cell Aging Negative Regulation Of Transferase Activity Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Telomere Maintenance Negative Regulation Of Biosynthetic Process Positive Regulation Of Microtubule Polymerization Signal Complex Assembly Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Microtubule Polymerization Focal Adhesion Assembly Positive Regulation Of Transferase Activity Cellular Component Assembly Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process	S-adenosylhomocysteine Catabolic Process Homocysteine Biosynthetic Process Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Extracellular Vesicular Exosome Assembly S-adenosylmethionine Cycle Regulation Of Extracellular Vesicular Exosome Assembly S-adenosylhomocysteine Metabolic Process Circadian Sleep/wake Cycle Homocysteine Metabolic Process Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Substrate-dependent Cell Migration, Cell Extension Purine Ribonucleoside Catabolic Process Chronic Inflammatory Response S-adenosylmethionine Metabolic Process Circadian Behavior Rhythmic Behavior Cellular Modified Amino Acid Catabolic Process Positive Regulation Of Viral Genome Replication Sulfur Amino Acid Biosynthetic Process Regulation Of MAPK Cascade Positive Regulation Of Organelle Assembly
Tagcloud ?		advantageous altered biomarkers candidates crc differentially discover earlier intensities labeled lgals1 mining nbs near nitrobenzenesulfenyl occurring pair paired peaks profiling proteome proteomic quantified ran rcn1 stroma validated vim zyx
Tagcloud (Difference) ?		advantageous altered biomarkers candidates crc differentially discover earlier intensities labeled lgals1 mining nbs near nitrobenzenesulfenyl occurring pair paired peaks profiling proteome proteomic quantified ran rcn1 stroma validated vim zyx
Tagcloud (Intersection) ?