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SPCS1 and TMEM74
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
SPCS1
TMEM74
Description
signal peptidase complex subunit 1
transmembrane protein 74
Image
No pdb structure
GO Annotations
Cellular Component
Endoplasmic Reticulum
Signal Peptidase Complex
Endoplasmic Reticulum Membrane
Membrane
Autophagosome Membrane
Lysosome
Lysosomal Membrane
Plasma Membrane
Membrane
Cytoplasmic Vesicle
Molecular Function
Protein Binding
Protein Binding
Transmembrane Transporter Binding
Biological Process
Signal Peptide Processing
Proteolysis
Virion Assembly
Viral Protein Processing
Protein Targeting To ER
Autophagy
Macroautophagy
General Adaptation Syndrome, Behavioral Process
Pathways
SRP-dependent cotranslational protein targeting to membrane
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
Synthesis, secretion, and deacylation of Ghrelin
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Maturation of hRSV A proteins
Drugs
Diseases
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
21926972
31043756
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Feeling worry (
29500382
)
Schizophrenia (
23974872
25056061
28991256
29483656
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Male-pattern baldness (
27182965
)
Interacting Genes
9 interacting genes:
AQP2
FIS1
FXYD6-FXYD2
RPRM
SLC22A2
SLC25A46
TMEM74
UBXN8
YIPF2
7 interacting genes:
AQP6
FATE1
LIME1
LMNA
MS4A13
SPCS1
TMEM42
Entrez ID
28972
157753
HPRD ID
07155
08702
Ensembl ID
ENSG00000114902
ENSG00000164841
Uniprot IDs
A0A5F9YFS9
Q9Y6A9
Q96NL1
PDB IDs
7P2P
7P2Q
Enriched GO Terms of Interacting Partners
?
Mitochondrial Fission
Lumenal Side Of Membrane
Polyol Transmembrane Transport
Renal Water Transport
Response To Water Deprivation
Glycerol Transmembrane Transport
Water Transmembrane Transporter Activity
Cellular Response To Mercury Ion
Metanephric Collecting Duct Development
Cellular Response To Water Deprivation
Organic Hydroxy Compound Transport
Glycerol Transmembrane Transporter Activity
Response To Mercury Ion
Membrane
Serotonin Uptake
Acetylcholine Transport
Histamine Uptake
Pyrimidine Nucleoside Transmembrane Transporter Activity
Choline Transport
Norepinephrine Uptake
Prostaglandin Transmembrane Transporter Activity
Xenobiotic Transport Across Blood-brain Barrier
Spermidine Transport
Toxin Transmembrane Transporter Activity
Monoamine Transmembrane Transporter Activity
Epinephrine Transport
Choline Transmembrane Transporter Activity
Spermidine Transmembrane Transport
Putrescine Transport
Norepinephrine Transport
Thiamine Transmembrane Transporter Activity
Thiamine Transport
Amine Transmembrane Transporter Activity
Quaternary Ammonium Group Transmembrane Transporter Activity
Spermidine Transmembrane Transporter Activity
L-arginine Import Across Plasma Membrane
Putrescine Transmembrane Transporter Activity
Polyamine Transmembrane Transport
Thiamine Transmembrane Transport
Histamine Transport
L-arginine Transmembrane Transporter Activity
Acetylcholine Transmembrane Transporter Activity
Response To Flavonoid
Response To Fluoride
Negative Regulation Of Fatty Acid Transport
Response To Hypobaric Hypoxia
Cellular Response To Peptide
Golgi Trans Cisterna
Golgi Medial Cisterna
Mitochondrial Membrane Fission
PH-gated Chloride Channel Activity
Nitrate Transmembrane Transporter Activity
Nitrate Transmembrane Transport
DNA Double-strand Break Attachment To Nuclear Envelope
Structural Constituent Of Nuclear Lamina
Carbon Dioxide Transmembrane Transporter Activity
Carbon Dioxide Transmembrane Transport
Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity
Lamin Filament
Nuclear Pore Localization
Signal Peptidase Complex
B Cell Receptor Complex
Negative Regulation Of Mitochondrial Calcium Ion Concentration
Monoatomic Anion Channel Activity
Renal Water Transport
Negative Regulation Of Mesenchymal Cell Proliferation
Virion Assembly
Ammonium Channel Activity
Signal Peptide Processing
Ammonium Transmembrane Transport
Ventricular Cardiac Muscle Cell Development
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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