SPCS1

Description		signal peptidase complex subunit 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Signal Peptidase Complex Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding
	Biological Process	Signal Peptide Processing Proteolysis Virion Assembly Viral Protein Processing Protein Targeting To ER
Pathways		SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Maturation of hRSV A proteins
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Feeling worry ( 29500382) Schizophrenia ( 23974872 25056061 28991256 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		9 interacting genes: AQP2 FIS1 FXYD6-FXYD2 RPRM SLC22A2 SLC25A46 TMEM74 UBXN8 YIPF2
Entrez ID		28972
HPRD ID		07155
Ensembl ID		ENSG00000114902
Uniprot IDs		A0A5F9YFS9 Q9Y6A9
PDB IDs		7P2P 7P2Q
Enriched GO Terms of Interacting Partners?		Mitochondrial Fission Lumenal Side Of Membrane Polyol Transmembrane Transport Renal Water Transport Response To Water Deprivation Glycerol Transmembrane Transport Water Transmembrane Transporter Activity Cellular Response To Mercury Ion Metanephric Collecting Duct Development Cellular Response To Water Deprivation Organic Hydroxy Compound Transport Glycerol Transmembrane Transporter Activity Response To Mercury Ion Membrane Serotonin Uptake Acetylcholine Transport Histamine Uptake Pyrimidine Nucleoside Transmembrane Transporter Activity Choline Transport Norepinephrine Uptake Prostaglandin Transmembrane Transporter Activity Xenobiotic Transport Across Blood-brain Barrier Spermidine Transport Toxin Transmembrane Transporter Activity Monoamine Transmembrane Transporter Activity Epinephrine Transport Choline Transmembrane Transporter Activity Spermidine Transmembrane Transport Putrescine Transport Norepinephrine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Amine Transmembrane Transporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Spermidine Transmembrane Transporter Activity L-arginine Import Across Plasma Membrane Putrescine Transmembrane Transporter Activity Polyamine Transmembrane Transport Thiamine Transmembrane Transport Histamine Transport L-arginine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Response To Flavonoid Response To Fluoride Negative Regulation Of Fatty Acid Transport Response To Hypobaric Hypoxia Cellular Response To Peptide Golgi Trans Cisterna Golgi Medial Cisterna Mitochondrial Membrane Fission
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