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NMI and GART
NMI
GART
Description
N-myc and STAT interactor
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Membrane
Cytosol
Extracellular Exosome
Molecular Function
Protein Binding
Identical Protein Binding
Nucleotide Binding
Catalytic Activity
Phosphoribosylamine-glycine Ligase Activity
Phosphoribosylformylglycinamidine Cyclo-ligase Activity
Phosphoribosylglycinamide Formyltransferase Activity
ATP Binding
Transferase Activity
Ligase Activity
Ligase Activity, Forming Carbon-nitrogen Bonds
Metal Ion Binding
Biological Process
Macrophage Activation Involved In Immune Response
Immune System Process
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Cell Population Proliferation
Response To Virus
Negative Regulation Of Type I Interferon Production
Negative Regulation Of Interferon-alpha Production
Negative Regulation Of Interferon-beta Production
Toll-like Receptor 4 Signaling Pathway
Innate Immune Response
Regulation Of Innate Immune Response
Positive Regulation Of Innate Immune Response
Negative Regulation Of Innate Immune Response
Positive Regulation Of Inflammatory Response
Protein K48-linked Ubiquitination
Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Protein K48-linked Ubiquitination
Brainstem Development
Purine Nucleotide Biosynthetic Process
GMP Biosynthetic Process
'de Novo' IMP Biosynthetic Process
Purine Nucleobase Biosynthetic Process
Purine Ribonucleoside Monophosphate Biosynthetic Process
Cerebellum Development
Cerebral Cortex Development
'de Novo' AMP Biosynthetic Process
Adenine Biosynthetic Process
'de Novo' XMP Biosynthetic Process
Pathways
SARS-CoV-1 activates/modulates innate immune responses
Purine ribonucleoside monophosphate biosynthesis
Drugs
Pemetrexed
Glycinamide Ribonucleotide
N-({4-[(1R)-4-[(2R,4S,5S)-2,4-diamino-6-oxohexahydropyrimidin-5-yl]-1-(2,2,2-trifluoro-1,1-dihydroxyethyl)butyl]phenyl}carbonyl)-L-glutamic acid
Diseases
GWAS
Crohn's disease (
23128233
)
Educational attainment (
25201988
)
Psoriasis (
25854761
)
Interacting Genes
57 interacting genes:
ANKRD13C-DT
BRAT1
BRCA1
BRMS1
C1orf216
CDKN2A
CDKN2D
CNKSR3
CNOT7
COPS7B
CYP2E1
EMILIN1
EXOSC5
GCSH
GOLGA8EP
HDDC3
HGS
HOXC9
HSPA8
HSPH1
IFI35
KDM1A
LCA5L
LSM4
MAD2L1BP
MCPH1
MORF4L1
MTMR6
MTMR9
MYC
MYCN
MYOM3
NECAP2
POMZP3
PSMA1
RYBP
SCEL
SFR1
SH3GLB2
SINHCAF
SNAPC5
SOX10
STAT1
STAT3
STAT4
STAT5A
STAT5B
STAT6
THAP8
TRAF5
TRIM72
TRIP12
TUBA3C
TUBA3E
TXLNA
TXLNB
UBE2I
5 interacting genes:
CDC42
KPNA2
OGT
PXN
TRAF6
Entrez ID
9111
2618
HPRD ID
04632
00716
Ensembl ID
ENSG00000123609
ENSG00000159131
Uniprot IDs
Q13287
P22102
Q59HH3
PDB IDs
1MEJ
1MEN
1MEO
1NJS
1RBM
1RBQ
1RBY
1RBZ
1RC0
1RC1
1ZLX
1ZLY
2QK4
2V9Y
4EW1
4EW2
4EW3
4ZYT
4ZYU
4ZYV
4ZYW
4ZYX
4ZYY
4ZYZ
4ZZ0
4ZZ1
4ZZ2
4ZZ3
5J9F
7JG0
7JG3
7JG4
8FDX
8FDY
8FE0
8FJV
8FJW
8FJX
8FJY
9NX6
Enriched GO Terms of Interacting Partners
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Nucleoplasm
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Cell Surface Receptor Signaling Pathway Via STAT
Growth Hormone Receptor Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Negative Regulation Of Signal Transduction
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Regulation Of Cell Population Proliferation
RNA Polymerase II Transcription Regulator Complex
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Developmental Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Nucleic Acid Metabolic Process
Regulation Of Programmed Cell Death
Regulation Of Erythrocyte Differentiation
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Cell Population Proliferation
Development Of Secondary Female Sexual Characteristics
Development Of Secondary Male Sexual Characteristics
DNA-binding Transcription Factor Binding
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Sin3-type Complex
Regulation Of Apoptotic Process
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
DNA-binding Transcription Factor Activity
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Cell Differentiation
DNA-templated Transcription
Positive Regulation Of Mesenchymal Cell Proliferation
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Mitotic Cell Cycle
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Development Of Secondary Sexual Characteristics
Positive Regulation Of Gene Expression
Regulation Of Myeloid Cell Apoptotic Process
Positive Regulation Of Metabolic Process
Regulation Of Signal Transduction
Signal Transduction
Cell Surface Receptor Signaling Pathway
Myeloid Leukocyte Activation
Regulation Of Type I Interferon Production
Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Regulation Of Cell Communication
Intracellular Signaling Cassette
Regulation Of Signaling
Myeloid Leukocyte Differentiation
Regulation Of Protein Localization To Synapse
Regulation Of Receptor Localization To Synapse
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Non-canonical NF-kappaB Signal Transduction
Regulation Of Protein Ubiquitination
Cell-cell Junction
Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Toll-like Receptor 4 Signaling Pathway
Cell Surface Toll-like Receptor Signaling Pathway
Regulation Of Post-translational Protein Modification
Regulation Of Intracellular Signal Transduction
Myeloid Cell Differentiation
Non-canonical Wnt Signaling Pathway
Positive Regulation Of Stress Fiber Assembly
Cell Surface Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Actin Filament Bundle Assembly
Macrophage Activation
Protein N-acetylglucosaminyltransferase Complex
Negative Regulation Of Non-canonical Inflammasome Complex Assembly
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Mononuclear Cell Differentiation
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Host-mediated Perturbation Of Viral Process
Cell Surface Receptor Signaling Pathway Via STAT
Leukocyte Differentiation
GBD Domain Binding
Storage Vacuole
Type I Interferon Receptor Activity
Type I Interferon Binding
Interferon Receptor Activity
Leading Edge Cell Differentiation
Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin
Positive Regulation Of Signal Transduction
Positive Regulation Of Type I Interferon Production
Response To Virus
Positive Regulation Of Cell Population Proliferation
Regulation Of Stress Fiber Assembly
Regulation Of Cell Population Proliferation
Regulation Of Cell Migration
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