CERS5 and CHPF

		CERS5	CHPF
Description		ceramide synthase 5	chondroitin polymerizing factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Golgi Membrane Cytoplasm Mitochondrion Mitochondrial Matrix Golgi Apparatus Cytosol Membrane Golgi Cisterna Membrane
	Molecular Function	DNA Binding Transferase Activity Sphingosine N-acyltransferase Activity	Protein Binding Acetylgalactosaminyltransferase Activity Transferase Activity Glycosyltransferase Activity Metal Ion Binding Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase Activity N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase Activity
	Biological Process	Lipid Metabolic Process Sphingolipid Metabolic Process Oligodendrocyte Development Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process	Chondroitin Sulfate Proteoglycan Biosynthetic Process
Pathways		Sphingolipid de novo biosynthesis	CS-GAG biosynthesis
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27618447 27618448) Hip circumference adjusted for BMI ( 34021172) Hypertension ( 27618447 27618448) Lymphocyte count ( 32888494) Mean arterial pressure ( 27618448) Schizophrenia ( 33169155) Systolic blood pressure ( 27618447 27618448 28739976)
Interacting Genes			11 interacting genes: ARHGEF5 BTRC EXOSC10 EXOSC6 LCOR LINC00839 NKX3-1 PIN1 PRKN SKIL SMAD9
Entrez ID		91012	79586
HPRD ID		13963	10829
Ensembl ID		ENSG00000139624	ENSG00000123989
Uniprot IDs		Q8N5B7	Q8IZ52
PDB IDs
Enriched GO Terms of Interacting Partners?		Acetylgalactosaminyltransferase Activity Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase Activity N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase Activity Chondroitin Sulfate Proteoglycan Biosynthetic Process Chondroitin Sulfate Proteoglycan Metabolic Process Golgi Cisterna Membrane Proteoglycan Biosynthetic Process Proteoglycan Metabolic Process Protein O-linked Glycosylation Glycosyltransferase Activity Glycoprotein Biosynthetic Process Glycoprotein Metabolic Process	Ubiquitin Ligase Activator Activity Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Poly(A)-dependent SnoRNA 3'-end Processing Nuclear MRNA Surveillance Nucleolar Exosome (RNase Complex) Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Sno(s)RNA Metabolic Process Beta-catenin Binding Ubiquitin-specific Protease Binding Regulation Of Dopamine Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Protein Localization Positive Regulation Of Establishment Of Protein Localization Histone Deacetylase Binding Protein K6-linked Ubiquitination Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Exocytosis Regulation Of Phosphorylation Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Nuclear Estrogen Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Androgen Secretion Regulation Of Intrinsic Apoptotic Signaling Pathway MADS Box Domain Binding Negative Regulation Of Spontaneous Neurotransmitter Secretion Regulation Of Protein Targeting To Mitochondrion Cis-trans Isomerase Activity RNA Surveillance Nuclear RNA Surveillance Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Regulation Of Primary Metabolic Process Leukocyte Cell-cell Adhesion Integrin AlphaL-beta2 Complex Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Dorsal Aorta Development Positive Regulation Of Retrograde Transport, Endosome To Golgi SCF Ubiquitin Ligase Complex Negative Regulation Of Intralumenal Vesicle Formation Positive Regulation Of Protein Linear Polyubiquitination
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