PIGQ and PIGC

Number of citations of the paper that reports this interaction (PubMedID 9463366)
41

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		PIGQ	PIGC
Description		phosphatidylinositol glycan anchor biosynthesis class Q	phosphatidylinositol glycan anchor biosynthesis class C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Phosphatidylinositol N-acetylglucosaminyltransferase Activity	Catalytic Activity Protein Binding
	Biological Process	Carbohydrate Metabolic Process GPI Anchor Biosynthetic Process	GPI Anchor Biosynthetic Process
Pathways			Synthesis of glycosylphosphatidylinositol (GPI)
Drugs
Diseases
GWAS		Disc degeneration (lumbar) ( 22993228) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	A body shape index ( 34021172) Daytime sleep phenotypes ( 27126917) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412)
Interacting Genes		4 interacting genes: PIGA PIGC PIGH SMAD1	4 interacting genes: DPM2 KLF10 PIGQ ZHX1
Entrez ID		9091	5279
HPRD ID		09307	03433
Ensembl ID		ENSG00000007541	ENSG00000135845
Uniprot IDs		B2RAU6 Q9BRB3	Q92535
PDB IDs
Enriched GO Terms of Interacting Partners?		Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Glycolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphatidylinositol Metabolic Process Glycerophospholipid Biosynthetic Process Membrane Lipid Metabolic Process Phospholipid Biosynthetic Process Glycerophospholipid Metabolic Process Glycerolipid Metabolic Process Phospholipid Metabolic Process Carbohydrate Derivative Biosynthetic Process Lipid Biosynthetic Process Organophosphate Biosynthetic Process Carbohydrate Derivative Metabolic Process Homomeric SMAD Protein Complex Organophosphate Metabolic Process Mesodermal Cell Fate Commitment Osteoblast Fate Commitment Lipid Metabolic Process Endoplasmic Reticulum Membrane Phosphatidylinositol N-acetylglucosaminyltransferase Activity Anti-Mullerian Hormone Receptor Signaling Pathway SMAD Protein Complex Heteromeric SMAD Protein Complex DEAD/H-box RNA Helicase Binding Phosphate-containing Compound Metabolic Process Catalytic Activity Primary MiRNA Binding Endoplasmic Reticulum Co-SMAD Binding Cell Fate Commitment Involved In Formation Of Primary Germ Layer Primary MiRNA Processing Positive Regulation Of Dendrite Development I-SMAD Binding Cardiac Conduction System Development UDP-glycosyltransferase Activity Hindbrain Development SMAD Protein Signal Transduction Positive Regulation Of Sprouting Angiogenesis Cardiac Muscle Cell Proliferation Positive Regulation Of Cartilage Development Midbrain Development MiRNA Processing Ureteric Bud Development Muscle Cell Proliferation Mesonephric Tubule Development Mesonephric Epithelium Development	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Glycolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphatidylinositol Metabolic Process Membrane Lipid Metabolic Process Glycerophospholipid Biosynthetic Process Dolichol Phosphate Mannose Biosynthetic Process Dolichol-phosphate-mannose Synthase Complex Phosphatidylinositol N-acetylglucosaminyltransferase Activity Phospholipid Biosynthetic Process Glycerophospholipid Metabolic Process Glycerolipid Metabolic Process Phospholipid Metabolic Process Core Promoter Sequence-specific DNA Binding Dolichol-linked Oligosaccharide Biosynthetic Process
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