PIGQ and PIGA

Number of citations of the paper that reports this interaction (PubMedID 9463366)
41

Data Source:
HPRD (in vitro)

		PIGQ	PIGA
Description		phosphatidylinositol glycan anchor biosynthesis class Q	phosphatidylinositol glycan anchor biosynthesis class A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Phosphatidylinositol N-acetylglucosaminyltransferase Activity	Protein Binding UDP-glycosyltransferase Activity Transferase Activity Glycosyltransferase Activity Phosphatidylinositol N-acetylglucosaminyltransferase Activity
	Biological Process	Carbohydrate Metabolic Process GPI Anchor Biosynthetic Process	GPI Anchor Biosynthetic Process Lipid Metabolic Process Cellular Response To Leukemia Inhibitory Factor
Pathways			Synthesis of glycosylphosphatidylinositol (GPI)
Drugs
Diseases			Paroxysmal nocturnal hemoglobinuria (PNH)
GWAS		Disc degeneration (lumbar) ( 22993228) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		4 interacting genes: PIGA PIGC PIGH SMAD1	4 interacting genes: DPM2 PIGH PIGQ PIGY
Entrez ID		9091	5277
HPRD ID		09307	02410
Ensembl ID		ENSG00000007541	ENSG00000165195
Uniprot IDs		B2RAU6 Q9BRB3	A0A2K4ZA02 P37287
PDB IDs
Enriched GO Terms of Interacting Partners?		Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Glycolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphatidylinositol Metabolic Process Glycerophospholipid Biosynthetic Process Membrane Lipid Metabolic Process Phospholipid Biosynthetic Process Glycerophospholipid Metabolic Process Glycerolipid Metabolic Process Phospholipid Metabolic Process Carbohydrate Derivative Biosynthetic Process Lipid Biosynthetic Process Organophosphate Biosynthetic Process Carbohydrate Derivative Metabolic Process Homomeric SMAD Protein Complex Organophosphate Metabolic Process Mesodermal Cell Fate Commitment Osteoblast Fate Commitment Lipid Metabolic Process Endoplasmic Reticulum Membrane Phosphatidylinositol N-acetylglucosaminyltransferase Activity Anti-Mullerian Hormone Receptor Signaling Pathway SMAD Protein Complex Heteromeric SMAD Protein Complex DEAD/H-box RNA Helicase Binding Phosphate-containing Compound Metabolic Process Catalytic Activity Primary MiRNA Binding Endoplasmic Reticulum Co-SMAD Binding Cell Fate Commitment Involved In Formation Of Primary Germ Layer Primary MiRNA Processing Positive Regulation Of Dendrite Development I-SMAD Binding Cardiac Conduction System Development UDP-glycosyltransferase Activity Hindbrain Development SMAD Protein Signal Transduction Positive Regulation Of Sprouting Angiogenesis Cardiac Muscle Cell Proliferation Positive Regulation Of Cartilage Development Midbrain Development MiRNA Processing Ureteric Bud Development Muscle Cell Proliferation Mesonephric Tubule Development Mesonephric Epithelium Development	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Glycolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphatidylinositol Metabolic Process Glycerophospholipid Biosynthetic Process Membrane Lipid Metabolic Process Phospholipid Biosynthetic Process Glycerophospholipid Metabolic Process Phosphatidylinositol N-acetylglucosaminyltransferase Activity Glycerolipid Metabolic Process Phospholipid Metabolic Process Lipid Metabolic Process Carbohydrate Derivative Biosynthetic Process Lipid Biosynthetic Process Organophosphate Biosynthetic Process Carbohydrate Derivative Metabolic Process Organophosphate Metabolic Process Endoplasmic Reticulum Membrane Phosphate-containing Compound Metabolic Process Terpenoid Metabolic Process Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Endoplasmic Reticulum Isoprenoid Metabolic Process Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis Lipoprotein Particle Receptor Binding Dolichol-phosphate-mannose Synthase Complex Astrocyte Activation Involved In Immune Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Dolichol Phosphate Mannose Biosynthetic Process Positive Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process In The Vacuole Amyloid-beta Clearance By Transcytosis Positive Regulation Of Amyloid-beta Clearance Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Amyloid-beta Clearance By Cellular Catabolic Process Clathrin Heavy Chain Binding Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Plasma Membrane Protein Complex Low-density Lipoprotein Particle Receptor Activity Lipoprotein Transport Astrocyte Activation Heparan Sulfate Proteoglycan Binding Apolipoprotein Binding
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